The Unit is back together and ready to take on their next assignment when a bomb filled with a nerve agent stolen from a nearby base is discovered to be on its way to their home. On the home front, Jonas and Molly make plans to spend time together, Mack is ordered to move out of his home, and Kim proposes a new show for the station but ends up handling a crisis.
The candidates are now two teams of five women and five men, competing on diagnosing and treating a wheelchair-bound man. Meanwhile House does experiments on himself to test what happens after death, and Foreman, at another hospital, is treating his team in a House-like manner.
Is life full of turning points or breaking points? Suddenly everyone in the Sutton household has to decide. For Eddie, it's deciding whether to stay on the streets or become a precint insider by applying for sergeant. For Jenn, it's balancing her love of her work with the dangers of the clinic. And for Cassie, it's having the guts to pursue her painting despite what the critics might say. But this proves easier said than done. With Charles MIA, Cassie feels like she's in free fall. She can hardly get out of bed. But that's only until her Prince Charming appears at the door, waiting to escort her to her very first gallery show as a real painter. Has Charles come back, or is Luc rushing in to take his place? Which one can Cassie really trust?
Denny believes a bet against Carl Sack in a cockfighting case is a sure thing; Alan and Lorraine represent an HIV-positive girl in a suit against her school; a widow hires Katie and Jerry after her husband commits suicide.
Things get kinky when Booth and Brennan follow murder clues that lead to a lodge used as an S&M retreat for "jockeys" and their "horses." Meanwhile, Angela tries hypnosis in an effort to figure out her elusive husband's name so she can finally divorce him.
A teacher claims that a student pursued her after she's charged with raping him.
Henry is stuck in Madame Tutu's ballet class when he'd rather go to Karate.
Horatio's son goes missing when a prison transport is attacked. Upon learning the identity of Kyle, he is targeted in order to get at Lt. Caine, who must find him before it is too late. Meanwhile, Ryan causes tension with his former colleagues when he is hired as an expert witness for the defense.
Joan runs away to Mexico with Aaron in attempts to keep him from leaving to Iraq. While in Mexico, Aaron realizes that he cannot run from the war and the two of them decide that they should get married before he departures. Meanwhile, Maya automatically assumes that Jabari has been using marijuana when she finds it in her home. Also, Lynn reaches another milestone in her music career, but she doesn't feel comfortable celebrating because of Joan and Aaron's problem.
Five teenagers must locate and secure ancient relics with unbelievable power, while at the same time stop a demonic corporation who want the relics for their power.
After the funeral of Hank's father Al, Hank comes back to L.A. with a new manuscript, that he wants Karen to read. After receiving a bonus paycheck, he buys a new car for himself and a new guitar for Becca.
George is at Betsy's birthday party and sees that they have something he has never seen before, a piñata! After George is told how to play, he goes on a free-swinging spree and winds up breaking everything in the backyard BUT the piñata! Aunt Margret tells George to stay outside and play with Charkie and asks him to put his blindfold on and follow her around the backyard with his other senses. Charkie soon escapes the backyard and a blind George begins to follow her around the city in a way other than seeing her.
The Man With the Yellow Hat is about to get a big job! He is going to go up into space to fix the Einstein-Pizza Space Telescope, which is broken and pointed right at Pizza's kitchen window. Dr. Einstein and Professor Pizza explain that the spaceship has a self-locking air lock but they accidentally forgot to make a way to open it from outside. George has to tag along to push the button that would let him in but is forced to go outside and do the job when the Man's tether breaks. Worse off, George is told he has only 2 minutes of air to complete the job.
Jeff finds himself in trouble when he tries to fix an issue Audrey is having with one of their neighbors.
Alan convinces Charlie that he needs to date more respectable women and sets him up with a judge. The two double date and their waitress happens to be one of Charlie’s ex-girlfriends. Charlie's date backfires the following morning, when he ends up in court in front of the judge.
After getting bullied Caruso stops bullying everyone else which upsets the balance at school. Julius tries to keep secret that he's been forced to take his vacation days.
Maria's dad Alan (Joseph Millson) has been turned to stone. The alien talisman is now in the possession of the Gorgon and her evil nuns, and they are preparing to open the portal to their world. Can Sarah Jane (Elisabeth Sladen) and her young friends free Alan from his stony state, prevent the nuns from unleashing more deadly aliens on the Earth, and avoid the Gorgon's petrifying gaze?
Brandon Adams joins the game in the place of Mike Baxter as action continues on High Stakes Poker with Eli Elezra, Phil Hellmuth, Jennifer Harman, Sammy Farha, Jamie Gold, Bob Safai, and Daniel Negreanu.