Abigail, an ugly high school girl, gets plastic surgery from her surgeon-mother to boost her popularity. However, her beauty hides a dark secret - when she kisses someone they're inflicted with life-threatening hallucinations. When Lana sees Abigail with one of her victims, she becomes the next target.
Michael fails a child-care course for grandparents, so Vanessa and Jr. refuse to let him baby-sit his grandchild.
Lorelai is a little offended that no one cares about her new relationship – until it becomes a topic of heated discussion at the town meeting.
Joan Rivers consults with Sean and Christian to have all of her plastic surgeries undone, because she wants her grandson Cooper to learn that you don't have to be perfect. When she ultimately learns what she will turn out like after the work has been finished, she decides to give up on her original plan and asks the doctors to schedule her for a facelift the next morning. Matt is concerned about Ava, who seems obviously depressed. He suggests they go away to Paris and start a new life together, which she reluctantly accepts after some convincing. Matt goes to McNamara-Troy to steal drugs for her to take with them. Christian finds him, and gets upset when he learns Matt is going to Paris. Christian goes to have a talk with Ava, and when trying to make a point using sex, he learns that Ava is really a transsexual. Julia, Sean, and Christian spend the night researching, and trace their way to Maryland and a Gender Reassignment center.
Although Nathan and Haley are already married, Tim insists on throwing Nathan a post-wedding bachelor party, while Brooke throws Haley a bachelorette party. Meanwhile, Lucas tries to decide whether he should visit Dan in the hospital. Karen decides to go back to school. Nathan gets a job working for Keith at Dan's dealership.
Rick has made friends with both Emma and Toby and when he's forced to work with Jimmy he may make another new friend but when Spinner, Jay and Alex rain on his parade he takes extreme measures. Meanwhile Joey has to sell his home and gets help from an old flame.
Brent and Lacey try to figure out their relationship; Emma's on the warpath
A mummified remains of a woman are found in the abandoned compound. The team discovers that the woman was missing for several months, was wearing a wedding dress when she died, and might've been a victim of a serial killer. The search for the murderer leads them to Florida, where they start looking for another woman who mysteriously disappeared after going to work. One of the clues they have is the old manual for good wifes.
When Carmen crazily redecorates her room, George snaps. When Carmen claims she should be able to do to her room what she wants, since she is an adult, George concocts a plan to get her to give up that thought. If Carmen wants to be an adult, she will act like one. She'll pay rent, bills and get her own food. But his plan soon backfires when Carmen doesn't relent and even resorts to getting a roommate who is a little over the edge.
Bessie's birthday cake turns up missing, and Robbie tricks everyone into believing that Sportacus stole it. The accusations land Sportacus in jail, so the kids get together to prove that he's innocent.
When Debra and Marie have a big fight, Ray is worried that Debra's anger will cause her to forget about their sex date that night. But rather than forgetting, the opposite happens when that anger is making the sex even better. Ray really enjoys the angry sex, so he starts doing things which makes Debra angry on purpose.
Andy finds himself at a loss over what to do when Delia naively stumbles upon Nina's vibrator and starts asking questions. Meanwhile, Ephram attempts to write Amy a love letter to show her the extent of his feelings. Amy makes it her mission to make new best friend Hannah (Sarah Drew) popular. Meanwhile, Harold and Rose question Bright's euphoria over being selected "employee of the month" and decide it's time for some parental intervention. Dr. Abbott becomes worried that his son Bright is settling too little in life when taking a job at a restaurant. Lastly, Andy treats a patient who needs a transplant, but won't tell his wife.
The CSIs must find the killer after a young woman is pushed in front of a moving bus. Alexx finds a bruise shaped like a hand imprint on the victim's back, proving that she was pushed in front of the bus, and her boyfriend, Jay Seaver, is the prime suspect. When one of Jay's office rivals also turns up dead, Jay reveals that he has a psychotic stalker, Claudia, who he thinks might kill to please him. However, when Jay hires a lawyer to protect Claudia, Horatio suspects that Jay may be more involved than they thought. Later, a man's body is discovered down an elevator shaft in a nearby building, and there is evidence to link the victims to a common killer. Meanwhile, Calleigh's father seeks her help when he fears that he may have killed someone after a night of drinking, and Horatio assigns a new CSI, Ryan Wolfe, to the case.
Mona pretends that Drew is her son in the hopes of winning over an artist that she is trying to sign who is a single mother. After her plan fails miserably, she suggests that Delicious stop chasing after artists that they have no chance of signing and instead conduct a talent search. Spencer continually bad-mouths all of Mona's ideas, and the two snipe at each other. Adam advises Spencer to finally deal with the tension between Mona and him before it destroys their friendship. Meanwhile, Dee Dee obsesses over trying to build a cabinet without any assistance; and Big Dee Dee drives Charles crazy when she tries to get over her depression by scheduling lots of ""quality time"" for them as a couple.
When Breanna and Arnaz admit to Flex that they are dating, he pretends to be happy about it, but really can't handle it, so he goes to great lengths to keep an eye on them, even as far as placing a locator chip in Breanna's car to track her every move.
Maya's cousin Ronnie is offended after she hires an agent. Upset that Maya refuses to acknowledge his role in her success, Ronnie demands ten percent of her $25,000 advance for writing the book. Joan has an awkward run-in with William and Monica at the cafe. She mistakenly believes that William is bringing Monica to Maya's birthday party, and tries to retaliate by bringing her own date, a boring shoe salesman. Meanwhile, Toni battles constant morning sickness.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
Sam has to jet off across the country in search of replacement lobsters when a truckload he purchased for a very important wedding, is stolen. Danny and Mike play detectives to determine the motive and culprit behind the theft. Meanwhile, Delinda's childhood boyfriend Jay (guest star Geoff Stults), shows up with news that he's dying of cancer- and of his final wish to sleep with her. Elsewhere, Mary books Michael Buble (guest starring as himself) to sing for the wedding; but, has to wrangle him in when he refuses to sing, instead wanting to perform comedy or a mime act.
Seating: Ned and Cookie to figure out how to sit at the cool table. Moze changes when she moves to the front of Science class and does so good that the teacher reverses the room, making Moze in back.. Gordy helps Cookie create the ultimate bus bounce. Tryouts: Ned tries to ascend to the basketball team and tries to become taller so he'll make the team. Moze goes out for volleyball, basketball, track, but must decide between them. With some help from Ned, she decides which is right for her. Cookie tumbles into cheerleading and demands equal rights after being kicked out.
Rosemary and Laura are called to Lyvedon manor to restore the now derelict wall gardens by the request of the garden's owner Martin Frazer. As a source of cheap labor to assisst Rosemary and Laura work on the gardens, Martin enlists the help of a group of inmates from the local prison. Initially Rosemary is suspicious of working with prisoners but soon gets used to it, but a greater shock awaits her when she witnesses Martin's odd cousin Jim jumping into the local fast flowing river, killing himself. Soon after at the local market, Rosemary is shocked to see Jim walking around, despite his body being found and identified by Martin himself... (Includes Parts 1 and 2)