Charlie helps Alan with his obsession of always having to get approval from the women in his life.
A drug lord is gunned in his Coconut Grove mansion and a suspect arrested at the scene claims he sells marijuana to Delko. Stetler, from Internal Affairs, investigates and the case quickly gets personal when Horatio gets involved. As for the shooting, the CSIs learn that two gunmen may have been involved. Also, Calleigh makes a major decision concerning her job.
After Dee Dee complains about Brett's sexist treatment of her, Charles and Spencer show up at the office to confront him. Their actions backfire, as everyone at the office begins thinking of Dee Dee as a "daddy's girl." Dee Dee, with encouragement from Mona, Phyllis and Big Dee Dee, sets out to prove herself by trying to land a successful athlete who has refused to sign with any agent.
A sportscaster becomes a full-time dad when his ex-wife decides to accept a job out of the country and his teenage daughter, Breanna, moves in with him.
When Joan decides to shut down the J-Spot, the restaurant starts bringing in money when William flips it into a sports bar.
Doug and Ray Barone have a "guy's night out." Meanwhile, Carrie gets a shock upon visiting her mother's grave.
Lois discovers she has a brother named Patrick and takes the family cross-country to meet him. It turns out; he’s locked up in a mental institution. Lois thinks he’s sane, so she checks him out to live with the Griffins. Meanwhile, Peter starts the Society for the Acceptance of Fat Men. But when all the fat men of Quahog are strangled one-by-one the group lives in fear. Who could the “Fat Man Strangler” be?
Steve becomes a famous author, and the entire family gets caught up in his celebrity, including Stan, who becomes an unbearable "stage parent." After Steve hooks up with an agent, he abandons his family to lead a "Cribs" lifestyle.
The escapades of Stan Smith, a conservative C.I.A. Agent dealing with family life, while keeping America safe.
Phil is fed up with trying to hide his secret about being from the future, and decides to tell the world. This results in he and his family becoming celebrities, but means he loses his special friendship with Keeley.
Grandad and Colonel Stinkmeaner have a beef. One man's blind. One man's feeble. Both are really, really old. Let "The Slugfest In Woodcrest" commence!
The Angel of Death returns to visit the Charmed Ones but they're shocked to learn that he's there for Leo. To try to stop him from taking Leo, Piper casts a spell that backfires, making every man a Leo lookalike, forcing Piper to take drastic measures and ask the Elders and the Avatars for help. Meanwhile, Billie continues her search for the truth behind her sister's disappearance.
A bit of bookender fun as the episode opens on a ‘Kevin Spencer Writing Meeting’ where Greg asks Rick for one more episode. He’ll be too busy helping runaway teen girls at “Camp WhoosYerDaddy”. Rick heads out to the Camel Toe Inn where he hangs out nearby, eavesdropping no the real Spencer family and interrogates them for ideas. Percy invites him on a B&E because he has a lighter. The theft doesn’t go well and Percy only gets some guard dogs, which he tries to pawn at Jimmy’s. Jimmy declines, as he’s going out of business. Percy depresses Jimmy so much that he manages to pawn a .32 calibre handgun, which used to belong to Rick’s mom. Finally they have enough to attend the air show and all get some shuteye except Rick and Kevin. Rick confesses to Kevin that he’s got a rough deadline and needs ideas. Kevin makes a deal with him. Kevin will rep him if Rick will mentor his writing. Rick mooches beer and gets institutionalized, Greg’s negotiations with Kevin go poorly and Percy and Anastasia drive off into the sunset…after the destruction of several downtown city properties.
A copy cat killer starts to terrorize Boston, Woody and Jordan are left to break the case. When they have to turn to the original killer for answers, Jordan is less than comfortable when the killer starts to get personal.
Various sketches including "Wheres Josh?" "Its got quite a kick hasn't it?" Make Up Girls sketch, and "Whats the final number."
When the body of a young woman is found by two children behind a dumpster, Barek and Logan soon learn she had recently returned from Guatemala and was suspected by the other passengers of being a drug mule. Their investigation leads them to noted plastic surgeon Dr. Christine Ensel, who has made a name for herself in recent years performing surgeries in Guatemala on people who would not normally be able to afford plastic surgery, but as the investigation continues, Logan and Barek suspect that Dr. Ensel has a lot to hide.
The embarrassed lieutenant of Skyway Patrol makes it his personal vendetta to take down XJ9.
George stalks Bree, despite her efforts to break up with him. Lynette takes charge of office politics. Carlos is paroled from prison and returns a new man, and Gabrielle is jealous of his new 'holier-than-thou' confidante. Susan meets her birth father and tries to begin a relationship with him.
The squad helps guard a prisoner who undergoes both physical and mental distress in order to find out vital information.. Bo requests to be taken off morphine. Sergio attends a family support group meeting. Eddy finds himself alone.
Dorie Russell is waiting for quintuplets, all 5 girls. Her husband seems more concerned than she is but she is set to bring her babies to their term of 36 weeks. All the departments are on call for the quintuplets as three of them have developped problems of different kinds. Meredith last night's stand shows up at the hospital with priapism and they need to call Derek Sheperd for a consult which puts Meredith in a very embarassing position. Alex and Derek must take care of a patient who has a tumor inducing thirst as a side effect. On the love side, Alex and Izzie are having some slight sexual problems, while Meredith goes on adding one night stands and Cristina is thrown off course by being "keyed."