While investigating the murder of man hired to make dirty bombs that terrorists intend to set off in Miami, Horatio finds the bloody fingerprint of his brother, Raymond, who he believed to be dead. However, when Raymond's son is kidnapped, he emerges from deep undercover and the estranged brothers must work together to save the boy. Meanwhile, while processing a crime scene, an unknown assailant holds a gun to Calleigh's head and, after a deadly confrontation in her gun lab, she is left doubting that she can continue as a CSI.
Flex feeling guilty for meddling in Breanna's love life, he admits to Breanna that he pursuaded Arnaz to let her go to California without him. Later, Breanna plans for college takes a suprising turn when she annouces to Flex that she is living in Baltimore with Arnaz.
Following Darnell's drunken love declaration, Maya enlists the help of Joan and William as she plans to break up his wedding. However, she soon has second thoughts. Joan tries to talk some sense into Darnell in the bathroom. Meanwhile, Toni gives birth to a baby girl before she is able to get in touch with Todd or the girls. Following the surprisingly easy delivery, Toni begins to wonder whether she really needs Todd in her life. Unable to hold back her feelings any longer, Lynn lashes out at Finn and quits the band.
As the missile speeds toward its destination, Mandy cuts a deal with Jack and the President to give up Marwan's location in exchange for a full pardon on all of her crimes. Tony and Michelle share a happy reunion, but Jack finds his relationship with Audrey shattered as she makes her feelings known. Logan's advisor suggests a drastic course of action when the Chinese government demands that Jack be handed over to them for trial. Palmer tries desperately to warn Jack of the danger against him. Jack's life changes forever as Tony, Michelle and Chloe help him to evade the trap set for him by Secret Service.
Mandy uses Tony as leverage to try to force Michelle to aid in her escape. A Chinese security operative captures and interrogates one of the CTU agents involved in the raid on the embassy. Palmer and Logan argue over the option of evacuating all major cities that may be targets for the missile.
With Ephram (Gregory Smith, who does not appear in the episode) gone and no longer feeling any significant ties to Everwood, Andy consults with Delia and contemplates accepting a prestigious position with a Chicago hospital. Uncharacteristically upset over this bit of news, Harold takes it upon himself to give Andy a reason to stay. Meanwhile, Jake moves in with Nina, causing Andy to question whether he should rock the boat by telling her how he really feels, and Bright finally admits his feelings to Hannah.
After somehow seeing Capt. Kenneth Push in a vision at a murder scene, Allison calls upon his assistance to find a serial killer. However, the only way Capt. Push can help is by literally putting his life on the line.
With her recent run-in with an anti-Semite, Gigi vows to only date Jews and seeks out Mr. Right on a Jewish internet dating site. She eventually strikes gold with Joe – a tall, handsome, intelligent animal lover who speaks four languages and wants children in Italy – but it turns out Joe is actually a Catholic who loves Jewish women. Meanwhile, Stella takes up stripping at an erotic dance class, and adventures ensue. Will Gigi be Jewish enough for Joe? Will Stella graduate from Stripper U?
Jimmy, Sheen, and Carl travel 15 years into the future, only to find that some things have gone wrong. Can they right the past to save their future?
In the final episode of the series' second season, the new owner of the Montecito will be making some big changes to both the staff and property at the casino. Jon Bon Jovi and Dean Cain guest star in the finale.
Dee Dee has difficulty preparing her law school valedictory speech because she is uneasy about the fact that she doesn't have a post-graduation job lined up. Big Dee Dee worsens the situation when she suggests that she give up on her career and just look for a man, then tricks her into going on a blind date. Meanwhile, Mona tries desperately to prevent her mother from moving into her neighborhood.
The discovery of nine human skulls leads Rush (Kathryn Morris) back to George Marks, the serial killer she was unable to incriminate months earlier, and who walked away a free man. As the detectives reinvestigate his mother's murder from 1972, George is forced to emerge from hiding to face Rush again. This time, their very lives are at stake in their final showdown.
Bree confides that she feels guilty because she and Rex were having a fight when he had his heart attack and that now he needs a pacemaker. Lynette's marriage takes a dramatic turn after an upset Tom vows that it is now her turn to go back to work and he'll be staying home with the kids. Carlos finally learns that John and Gabrielle have been lovers for a while, and vows revenge as he is carted off to jail. Mike takes Paul out to a deserted quarry, intending to shoot him.
Mining magnate George Hearst arrives while the camp is preparing for a celebration. Yankton officials react to a Swearengen power play. Violence erupts among the town's Chinese population.
Jeremy puts the 4 door Mercedes CLS to the test and likes it. The Stig takes the AMG Mercedes CLS around the Top Gear track for a power lap. James likes the Honda Element, which is not sold in the UK.Richard and James play 5-a-side Aygo football and the new Range Rover Sport goes head-to-head with a Challenger II tank. James Nesbitt is the Star in a Reasonably Priced Car.
A sexually transmitted disease breaks out and affects several members of the hospital staff. Chief Webber promptly calls a meeting. Meanwhile, the chief reluctantly tells Dr. Derek Shepherd about his own medical concerns. Izzie and Cristina worry about a patient's wife and daughter who can't agree on his care. Burke treats his college buddy Bill, whose medical diagnosis raises some questions regarding his wife's actions. Then just as Meredith and Derek grow more intimate, a surprise is revealed.
Charlie unknowingly sleeps with an older man's trophy wife while Jake has to read a paper to his class.
The boys star in another one of J-Roc's greasy porn films. Randy and Lahey manage to get Ray arrested for disability fraud.
In the series finale Sue Thomas gets promoted to senior investigative analyst for the F.B.I. Sue is thrilled with the promotion but soon realizes that heading to New York City would mean leaving her friends. Jack becomes a victim of identity theft and feel sad when he learns of Sue is promotion. While trying to catch the person who's committing identity theft Jack realizes that he was almost shot at and might never have gotten to say goodbye to Sue.