Vic and Monica stake a deal with the DEA to shut down Mitchell's tar heroin operation. When the bust comes up empty, Vic's suspicions of Shane grow, until Shane proves himself by coming up with a key piece of evidence that reveals a large stash of tar being stored at a local church. Meanwhile, Dutch and Claudette's friendship continues to feel strain as they try to tie a young woman's murder to a suspected serial killer. Plus, Julien takes a stand against Monica's policy, then goes to David for support when she suggests he consider transferring out of Farmington.
Turk won't open up at couples therapy. Elliot refuses Dr. Cox's romantic advice, when a very attractive man saunters into the hospital. J.D. learns a lesson in humanity from a dying old woman. The Janitor accidently lets a bunch of rats run around Sacred Heart.
The office staff play a basketball game against the warehouse workers in which Jim shows off to impress Pam and upstage her fiancee who is on the opposing team.
Keith gets violent with Dan after learning that Dan paid Jules to fall in love with Keith. Anna turns Felix in to the school authorities after learning that he was the one who vandalized Peyton's locker. Lucas and Brooke discuss Brooke's possible move. Meanwhile, Nathan chances Haley in the hope of bringing her home. Brooke decides to move in with Karen.
Streaky programs Dogbot to help Krypto so he can have more time with Kevin.
On the morning of his Julliard audition in New York, Ephram makes plans to meet up with Madison (guest star Sarah Lancaster) for coffee where he finds out that she was pregnant with his child. This devastating revelation causes Ephram to make decisions that will alter the course of his life. Amy tries to figure out what this will do to her and Emphram's relationship. Meanwhile, Dr. Abbott counsels a man (guest star Chris Penn) whose son may die as a result of a hunting accident.
Horatio's life is changed forever when he learns important information about his deceased brother. Horatio must now figure out what to do with this information about his brother, Raymond, and whether or not to tell Yelina. Meanwhile, the team investigates when a woman is murdered at a crowded bar after she's approached by a female employee of a service that helps men pick-up women. Also, when Delko loses his badge after some reckless behavior and it's used in a crime, he must locate the badge before it's used again.
Curtis brings in a suspect who has critical information about Marwan's next strike. Michelle orders Curtis to use harsh methods to interrogate the suspect, but things get complicated when Marwan sends a lawyer to defend his rights. Logan's advisors begin to worry as he continues to exhibit fear in the face of the ongoing terrorist threat.
After Amy spends an hour chatting with Ray while he is trying to watch the basketball game, he tells Robert that she talks to much, which of course, Robert repeats to Amy, leading to a confrontation between Ray and "Lady Chatterly."
In an attempt to lure the sisters out of the manor, Zankou sends his underlings to attack Leo, in order for him to search the house for the Nexus and release the Shadow, the ultimate power. Meanwhile, in order to protect his parents Wyatt magically shrinks them and traps them inside a dollhouse, and Phoebe is left in charge of the newspaper.
Wyatt has taken Serena out on a few dates now, but their ""relationship"" is yet to be defined, and Wyatt finally gets up the courage to ask her if she'd like to be his girlfriend. Serena tells Wyatt she thinks she's a little too ""mature"" for him, being one year older and all, and Wyatt is crushed until Jonsey convinces Serena that younger guys are puppies – ""easily trainable"". Wyatt takes Serena on what Caitlin assures him is a ""mature"" date, but it ends up backfiring on him big time. Meanwhile, Caitlin's dream of being part of the Albatross and Finch family looks like it just might come true. The usually ‘legacies only' stores is holding an open audition for new Greeter Gods and goddesses and Caitlin has got her snobby stares to perfection. But her dreams of getting out of them lemon for good are shattered when the A&F crew choose Jonsey instead. Caitlin learns through Jonsey's experience that working at A&F isn't all the catalogues crack it up to be…
Rose tries to help the brothers sort out their feelings, when Charlie and Alan take their personal frustrations out on each other.
Jack runs into a bounty hunter named Joe who used to work at the FBI until his daughter died. He blames Jack for his daughter's problems. Although the team searches for Fantasia (a new designer drug) Levi learns that he will grace the box of the latest dog food only to learn that it isn't so easy to do. Sue and Lucy begin the have problems with the photographer that has chosen to photograph Levi. Sue and Lucy learn that Levi will have to compete with the photographer's dog in order to be included in the latest dog calendar.
Ride Owner: Vivian. Female. Owner's Ride: 1986 Toyota Van LE. Additions & Improvements: -Paint, light to dark blue fade with atomic orange flame -17" Alba Impulse rims with Cooper tires -Automatic door openers -Blue and gray leather seats -Stain Resistent carpet -2 7" monitors on the ground in the back -2 built in dog bowls -Doggy cleaning system, bathing beauty -Custom videogame console of a plug and play Ms. Pac Man with a 22" monitor -Desktop computer with pentium 4 in the van with a 17" monitor and a wireless keyboard -Neon lights in the walls of the van -2 10" subwoofers -40gb Nomad mp3 player -Refrigerator with west coast water -4 monitors in the back -Gift from X, HP ipaq pda with custom West Coast Customs case
Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.
Gob hides George Sr. while the model home's plumbing is checked; George Michael helps Ann protest Maeby's new movie; Tobias takes a liking to Kitty after Michael asks him to keep an eye on her.
Through Professor Frink's future machine, Bart and Lisa see their lives in the year 2013, where Bart steals Lisa's chances at going to an Ivy League school in order to impress a skater girl named Jenda while Homer (now separated from Marge and living in an underwater apartment) fights Krusty the Clown after Marge begins dating him.
Lois goes over to visit Ida, but gets unpleasantly surprised by the St. Grotus Day festival. Malcolm fails a music appreciation course, and reluctantly goes to Dewey for help. Reese and Hal secretly watch scary movies while Lois is not around, but it ends up revealing some unexpected secrets about both Reese and Hal.
While George is feeling a little less masculine because of the way Izzie and Meredith have been treating him (like a sister), Izzie is assigned to a patient about to loose all of his masculinity. Cristina, true to her competitive spirit, shows up early and assigns herself to an ill woman, who happens to have been Meredith's moms scrub nurse. Alex, meanwhile, is busying himself copying and pasting pictures of Izzie's racy magazine spread all over the interns' locker room. And while Meredith is trying to cope with her mother's Alzheimer's, Derek treats a patient who has managed to get nails stuck in his head.