As the snow falls in Queens, Carrie heads out to buy an iPod - but instead of achieving musical nirvana, she finds herself stranded on a cold street and in a moral dilemma. Meanwhile, when a couple invites Doug in from the cold, he manages to quickly use up his welcome when he dispenses very un-welcome relationship advice.
When Krypto and Streaky meet up with a fire Dalmatian named Smokey, who has the worried of a new puppy on his mind. Streaky assumes the new dog is a Smokey "replacement", much to Krypto's disbelief. Streaky gets the bright idea to use Krypto as Smokey's super-double.
When Jerry WOOHPs the girls right in the middle of a homegrown mani-pedi (courtesy of Clover, see b-story), they know it must be serious... and it is. Jerry informs the spies that fellow teen spy hottie Britney (from ""Alex Quits"") has crashed in a WOOHP chopper on a remote island in the middle of the Atlantic Ocean. Jerry explains to them that the island is a top secret holding facility for WOOHP's most dangerous baddies (humans, robots, mutants, aliens, you name it)! Just when the girls think things couldn't get any worse, Jerry informs them that Britney's chopper destroyed the island's security system when it went down -- and now the island's ""residents"" are running totally wild. And one more thing: the girls only have a few hours to save Britney before the island self destructs! In a b-story, Clover becomes a ""Beautylicious Betty"" -- a peddler of overpriced, shoddy beauty products that eventually enrage all of her customers.
In an attempt to talk to Sydney, Katya Derevko deliberately poisons herself and is temporally taken out from her cell. Once Nadia tells her sister about this, Sydney visits her aunt to tell her to stay away from Nadia. However, Katya unsettles Sydney by telling her that someone framed her mother as a means of getting her killed. Sydney sets off in search of the truth behind this story. Meanwhile, Vaughn becomes a rogue agent by getting involved with the people who might know his father's whereabouts. In the end, he and Sydney find out that the man behind these two plots is no other than A. Sloane. However, things are not exactly as they seem to be.
When the body of a young woman is discovered at a laundry facility, the bed sheets she is wrapped in lead Mac and Stella back to an upscale New York hotel that houses diplomats from around the world when the United Nations is in special session. Meanwhile, Danny and Aiden investigate the death of a homeless man found dressed as a human statue. By all accounts, the prank is deemed a misdemeanor, but Danny decides to delve further and his refusal to stop the investigation puts him at odds with Mac.
The bludgeoned corpse of a promiscuous lawyer is found in her office and detectives treat her former lovers as suspects until DNA evidence points to a co-worker. This crossover continues on Law & Order: Trial By Jury S01E08 Skeleton (II).
A black kryptonite explosion splits Lex in two and his evil side - Alexander - is released. Alexander imprisons Lex in the mansion then gives full vent to his evil side - he threatens to evict Lana from the Talon unless she becomes his mate, jousts with Lionel, and tries to kill Clark and Chloe when they figure out his secret.
Butters is freaked out when he thinks he can communicate with the dead. Although his parents have made it clear to him there are no such things as ghosts, Butters is sure one is haunting him. Butters knows he has to give up his ghost pal or be put into a mental institution.
A series of fire drills leads Veronica to discover that Neptune High has been receiving bomb threats, so she enlists Wallace and Mac's help to investigate classmates who could pose a serious threat to the school, including new student Ben. Meanwhile, Keith stuns Veronica with the news of who he's been secretly dating. Later, Duncan confronts Veronica about her ongoing investigation into his sister's death.
J.D. and Carla get the silent treatment from Turk, who can't seem to control his emotions, after learning about their kiss. Dr. Cox reluctantly seeks the help of Elliot, when an epileptic patient won't listen to him. The Janitor feels emasculated by his new uniform. Jordan trys Botox.
A tip from Lemonhead's juvie would leads Vic and Monica to take down a major heroin operation with connections to Antwon Mitchell. Monica continues to battle Aceveda as she tries to sell her new policies to the community, and Julien begins to doubt her methods. Claudette loses trust in Dutch when she suspects he made a backroom deal with the D.A. And Shane and Army find themselves over their heads with Antwon when he blames them for Vic's heroin bust.
House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.
Michael arranges a morale-boosting birthday party for Meredith and is determined to come up with the funniest message in her card. Dwight wants a pact with Jim to fight the downsizing, and Michael regrets showing off when Oscar asks for sponsorship for a charity walk being undertaken by his nephew, who has cerebral palsy.
Danny has found a potential new member of the gang, Trevor (played by Lee Ingleby). He's a short con artist, who's very good at what he does, but his marks are not always the greedy; he also targets the elderly and the poor...
When Krypto is rendered powerless by the effects of red kryptonite, Ace the Bat Hound gives him a bat collar so they can track down the Penguin's birds.
Jim and Cheryl adjust the clocks to get the kids to bed earlier so they can have more quality time together.
The whole school has caught Yu-Gotta-Go fever, a role playing card game, except Chuckie. When he finally starts playing, it becomes an obsession, and he's hired by Angelica to do her chores in exchange for more cards. He becomes one of the school's elite players, but in the pursuit of an elusive card, he nearly parts with the valuable stamp collection that Chas has passed down to him. It's up to his friends to keep him from getting in over his head.
The team investigates a suicide case, believing that the main reason of her death is a nervous breakdown, but Ducky believes that she was actually murdered. FBI Special Agent Fornell helps them in the investigation. The team discovers that the dead woman was involved in a love triangle and that this may have contributed to her death.
George gets caught up in some bad family ties when he lets Vic give him money to go out on a date with his sister.
When Jr. wins a national competition for his cartoon entitled ""My Wife and Kid"" -- based on himself, Vanessa, the baby and the rest of the Kyle family -- it catches the attention of ABC. Michael becomes Jr.'s agent, but the meeting with the television executives goes badly, crushing Jr.'s dream opportunity, so now Michael has to find a way to rectify the situation. Meanwhile, Claire threatens to break up with Tony unless he can bring some ""umph"" into their relationship.