Distraught over her break-up with Clark, Lana goes to a rogue medical student who experiments with a dangerous kryptonite-based serum that allows people to flat-line but see their dead loved ones. Lana attempts to see her dead parents using the serum and when Clark returns from Honduras to help her, the doctor injects him with the serum and Clark speaks with his dead father...who warns him that Lionel knows his secret. Meanwhile, Lionel continues working to get closer to Martha, and Lex has a near-death vision of his mother.
Sam and Dean battle a Shtriga, a witch that sneaks into childrens' bedrooms and sucks the lives out of them. Dean must relive his childhood when he remembers that he encountered the Shtriga years ago.
Number forty-five "Ditched Jessie to Marry Joy" is next on the list when Jessie, Earl's ex-girlfriend returns to town seeking revenge. Earl must protect Joy in a lakeside retreat while Randy fights not to reveal their location to Jessie.
Overcome with guilt and frustration, Weevil asks Veronica for help to bring Felix's true killer to justice, but realizes he may have to take matters into his own hands.Meanwhile, Keith reviews a strange DVD that Woody receives in the mail, and relationship troubles brew between Wallace and Jane, and Mac and Cassidy.
Rachel invites the gang for a weekend getaway at her family's cabin. Craziness will ensue, including a game of "I Never" which will cause characters to do things they normally wouldn't, and a nasty little issue Mouth has been harboring toward Rachel will surface. Meanwhile, Karen will confront Dan about Keith's death. Could she suspect the truth?
A human finger bone found in the clutches of a drowning victim leads to a search for buried treasure.
Libby lends a helping hand to Hurley to support him when he begins to think the island is having a strange effect on him. Hurley begins to see Dave (guest-star Evan Handler, Sex and the City) on the island, who was his friend in the mental institution Hurley was in. Also, Locke's sense of purpose is shaken when the prisoner gives him new information about the hatch.
Cartman and Kyle are at war over the popular cartoon, Family Guy. Kyle loves it and Cartman hates it. When the show airs some controversial content the boys go on a cross country chase with the fate of Family Guy lying with the first boy to reach Hollywood.
Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.
When a teenage boy commits suicide after firing on a doctor and hitting an innocent party, Fontana and Green investigate why he was after the doctor to begin with.
Benny is gets really mad when she discovers that George has rigged the results of a productivity contest at the factory against her favor, but gets the ultimate revenge when George can't sleep at night without dreaming of his dysfunctional childhood.
Haseo's entrance into The World is marked by a hostile attack - and a crushing defeat. His adventure appears to be over before it started until a mysterious stranger gives him new life.
Fifi Box is dressed in a tracksuit, Frank Woodley is fitted out in Roman era finery, Angus Sampson is scrubbed up and ready, and Peter Rowsthorn looks like a professional.
For the quickfire challenge, the contestants are brought into an isolated room with many random exotic foods. They have to guess what they are with a blindfold on. For the elimination challenge the contestants are put into pairs and have to make fusion dishes with Latin and one other type of cuisine.
A teenage couple kiss one another goodnight when the dead body of a woman is thrown from the top of an apartment block, killing the young man. DC Bain links the dead woman to a dating agency for married people, and DI Alembic goes undercover as a client.
A manhunt ensues when Victor Paul Gitano, a recently released sex offender, kidnaps two children after killing the rest of their family. Benson and Stabler pursue Gitano only to find their own relationship challenged as both experience opportunities where they put their personal relationship ahead of their job. After having her throat slashed, Benson requests for a new partner when she hears what Stabler has to say about their relationship and their job.
Moz is a drug dealer and has very strange clientele who come and go from his flat.
Jonas and the team carry out an assasination of a terrorist in Spain. However, they soon find out that the government called off the mission and will now not protect them in the country which means there only hope is to escape. Back at the base, Molly learns that her daughter Betsy wants to drop out of college and Kim thinks about taking a college course herself.