Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
Ed suspects that the Montecito's security system has been breached and that he and his hotel staff are now under surveillance, Danny and Mike are employed to expose the identity of the phantom mole. Meanwhile, Sam is seduced by a high-rolling vampire when he mysteriously appears in her room. Elsewhere, DeLinda escorts her sheepishly innocent Amish cousin as he sows his oats on the Vegas strip before returning to the simple life.
After returning from New York feeling lost and confused and needing Amy for support, Ephram considers his options in the wake of Madison's (Sarah Lancaster, who does not appear in this episode) life-altering revelation. Ephram tries to find the baby by going to Child Services Office, but finds out that Madison signed the adoption papers with "father unknown" and terminating the parent-child relationship with "Unknown Birth Father" leaving Ephram completely crushed. Amy tries to get Ephram another audition at Julliard after he missed his first appointment due to the emergency with Madison and the baby, but it doesn't go well. Meanwhile, a tired Andy is a little stunned upon learning the extent of Nina's feelings for Jake and with a little encouragement from her friend Bright, Hannah decides to go on a date with a smitten Topher (guest-star Lukas Behnken).
Jabari becomes extremely sullen and disrespectful, and begins talking back to his parents. After he runs away from Joan's house while she is watching him, Maya and Darnell finally learn the source of Jabari's anger: he is upset over Darnell's engagement because he wants his parents to reunite. Maya and Darnell struggle over what to do about their son's despair. Meanwhile, Lynn and Toni refuse to believe that William's depression stems from his car's inability to pass a smog test. They insist that he is actually upset about the break-up with Joan, and pressure him to share his feelings.
Streaky accidently gets the power of invisibility. However, he soon learns the about the problems it causes.
After Mona complains about being bombarded with demos and Spencer's refusal to pay back his debts, Dee Dee encourages her to become more assertive and not let people take advantage of her. Mona follows her advice and re-possesses Spencer's new jacket and shoes. However, Dee Dee's words come back to haunt her when her sister refuses to listen to a demo by Dee Dee's handsome and influential new boyfriend. Meanwhile, Phyllis enjoys being pampered at an expensive shoe store after a salesgirl mistakes her for Big Dee Dee.
Jordan suspects foul play in the death of a man. When the wife of the dead man takes Jordan and others hostage Woody, Dr. Macy and the others race to solve the murder to save one of their own.
The murder case of a young mill worker is re-opened when Rush learns that a recent parolee admitted to stealing money off the victim's body.
Meredith realizes that she must take on a lot more responsibility when she is told that her mother needs to sign over all of her assets to her. As Izzie prepares to have a party for her boyfriend Hank (the scale of which is unknown to Meredith), Meredith has her first heart surgery. During the surgery she fears that she has fallen asleep and damaged the patient's heart. Meanwhile, Cristina and Burke hit it off. At the party, Meredith and Derek get caught together by Dr. Bailey.
Wolcott reports his gold-claim acquisitions to his employer, George Hearst, and Nuttall shows off his new bicycle. Meanwhile, Miss Isringhausen reaches an agreement with Swearengen, who also meets with Bullock to discuss alternatives to annexation.
Reese befriends a pack of troublesome stray dogs; Dewey feels conflicted when he starts seeing another mother-figure; Hal unwittingly becomes a motivational speaker.
The sisters scramble to recover Pandora's Box when it falls into the hands of a shapeshifting demon who intends to open it and fill the world with all of its sorrows. Meanwhile, Paige's Whitelighter side rises to the surface, when she begins hearing calls from the Elders, and Leo and Piper clash over parenting issues - namely raising magical children.
Ride Owner: Eric. 20 Year Old Male. Owner's Ride: 1998 Mitsubishi Eclipse. Additions & Improvements: -Paint, 1 side tangerine candy and the other side candy blue with graphics across the car -18" Volk rims with Goodyear run flat tires -Tire pressure sensor -Bomex body kit -Dual exhaust on both sides of the rear skirts -Seat coolers in the seats -West Coast Customs cola energy drink dispenser in the arm rest -Flip down monitor -Mini baggage claim belt in the trunk of the car -3 Sony psp's on the baggage claim belt with NFL street 2 unleashed and need for speed underground rivals videogames -2 MA audio 10" subwoofers -Gift from X, luggage and new boost mobile cell phone Eric has officially been pimped. Final Look -Norrin Radd
Three old men from Yorkshire who have never grown up face the trials of their fellow town citizens and everyday life and stay young by reminiscing about the days of their youth and attempting feats not common to the elderly.
When Jonsey starts working at The Penalty Box and doing a much better job at sales than Jen, Jen is furious. The two start competing for commissions and the customers become the spoils of war. The competition extends to their personal lives when Jonsey makes a comment at lunch about how ""guys are just naturally better at some things"" and Nikki, Jen and Caitlin take offence. Soon the lines between the sexes are drawn and an all out all-over-the-mall battle of the sexes begins, culminating in the ultimate dare of a lifetime. Meanwhile, Jude starts a Dude Daycare at The Mall and ends up with more kids – and trouble – than he can handle. Will the guys have to ask the girls for help after all?
Cory and Trevor start to work for Julian. The boys steal drugs from Cyrus and hatch a plan to hide it all until they can find a buyer.
A lesbian cruise in the Caribbean proves eventful for Dana, Alice, Shane, Jenny and Carmen. Bette and Kit struggle to reconcile with their estranged father, Melvin, during his visit.
Time is running out for the Doctor as Downing Street announces mankind's first Interplanetary War.
The Shredder is leaving Earth in a spaceship of his own construction intent upon wreaking havoc on the Utroms and the galaxy. But he's taken on some unwanted passengers and they're not about to let the Shredder get away.
The Warriors travel to Tokyo in search of the Zing Zom-Bone, a Shen-Gong-Wu that can turn anyone into a zombie-like state. Once there, they meet up with Kimiko's father, who is the owner of a major video game company. Unbeknowst to the Warriors, Kimiko's father brings in Pandabubba as his new business partner, not knowing he's in fact a criminal. Jack finds the Zing Zom-Bone first and brings it to Pandabubba who uses it on the company's workers and Kimiko's father to do his bidding. Can the Warriors stop Pandabubba a second time?