Mitzi Huntley arrives back in Nate and David's lives thanks to a comparison-shopping widow. Meanwhile, Ruth's estranged sister Sarah arrives for an unexpected visit. Later, a vodka-fueled family dinner casts a pall over Nate and Brenda's happy news.
Dewey rules, thanks to his new dog that intimidates Malcolm and Reese; Hal and Lois hit the town with big plans---and flu symptoms.
Michael has trouble dealing with the news that his new boyfriend Ben once slept with his best friend Brian. Debbie needs to do something about the dead boy found behind her diner. She impresses Detective Horvath with her sleuthing. Ted gets a shot at being accepted by the elite A-Gays of Pittsburgh.
A girl who is obsesed with Lori switches bodies with her. Tommy and Merton don't believe Lori in Alices's body but become suspicious at Alice in Lori's body, because she doesn't know what 'wolf out' means. They become even more suspicious when 'Lori' cries. Their suspicions are confirmed when 'Alice' knows Tommy's sercret and 'Lori' doesn't. A subplot is Merton has his own tv show in which a guest star is an rival of his. 'Alice' 'Lori' and Tommy(wolfed out) crash it. Merton averts the camera. The strange creature that Mertons rival Fong (remember him?) brought gets removed from its own body by Alice, in Lori's body. Metron tells them that the three of them have to hold each others hands to undo what Alice did. With the help of Fong they get the three to hold hands. Lori pulls the creature from her body and the creature(what was it called?) pulls Alice from it's body and Alice disappears.
A Bang Baby named Madelyn Spaulding turns everyone in Dakota into a zombie. Everyone but Virgil, that is.
Earth finds itself threatened by something even larger than the Goa'uld when the team learns that an asteroid is on a collision course with the planet.
When construction starts next door to the shop, Manni, Bernard and Fran try to decide what to do while it continues.
A group of disparate fugitives from an interplanetary tyranny find themselves in control of a massively powerful starship.
After a near-fatal incident with Logan, Max decides to end their relationship for good. A murder committed by Alec's Manticore twin, Ben, puts him under suspicion and places all of the transgenics in jeopardy...thanks to White and his leakage to the media. Meanwhile, Joshua finds the perfect woman, but can't find the courage to confess his secret.
A rebellious 16-year-old teenager is raped and murdered; the case becomes complex when they learn that her stepfather is a judge with whom she has had major problems.
Jack comes upon ruins of a village and realizes it is his home. He then reflects on the past when he was a young boy.
Jack takes a vacation and uses the time to fulfill his dream of writing a novel. But when he gets frustrated, he pays an English professor to write the book for him. Meanwhile, Maya, Elliott and Nina are left to oversee the magazine and can't agree on even the smallest decisions.
Sylvia and Mark managed to save Buki's life after the tunnel collapse. Roisin told Cassie that she had withdrawn the statement and so was staying at Larkhall. Rhiannon asked Buki to get her drugs but Buki was scared off by the Julies. Jim tried harder to split Karen and Mark up, this time by banning them acting like a couple at work. Roisin asked Buki for ""something to help her sleep"". The Julies took painful revenge on Rhiannon's boyfriend/pimp by tipping boiling water all over him in the visiting room - they were put on report and were devastated to discover that they would have been released in a few days because without Virginia, the case against them collapsed!
D'Argo and Rygel meet Braca and Scorpius in a cafe to conduct negotiations when it is unexpectedly attacked.
Jane Galloway lives in fear. Her doors are triple-locked. Every shade is drawn. The bathroom window is nailed shut. An alarm system is activated. Who killed Jane, and how could the murderer have possibly entered, and left, the house?
As Dr. Greene's brain tumor begins affecting his coordination, he becomes concerned that his fate will be similar to the terminally ill patients he treats.
Joey prepares for an interview with Soap Opera Digest, although he's afraid of saying something stupid and getting himself into trouble, so he enlists his friends to make sure things go well. During the interview, he reminisces about his past acting experiences, his friends and his romantic life.
The boys have to sit through "The Russell Crowe Show" in order to see the premiere of the trailer for the new Terrance and Phillip movie. Meanwhile, Chef’s new TV has taken on a life of its own.
Ben decides that he wants to play an active role in his child's life. Lauren is pleased; but has already made arrangements to move to Arizona to be near her parents. Ben talks to Professor Hodges about the possibility of transferring to the University of Arizona. Adam's design wins the contest, and Felicity accepts an offer to stay in New York and help with his project. Hodges tells Ben that the deadline for admission has passed, but his friend can pull some strings and get him accepted. He must make his final decision in the next day. Felicity is upset that Ben failed to tell her about his possible move. She tells Adam that she may have to turn down the job. Trevor convinces Ben that Noel is still trying to make a move on Felicity. A tearful Felicity confides in Noel about Ben's situation. Ben catches them in an embrace and becomes angry. He says that he wouldn't have slept with Lauren if Felicity hadn't cheated on him. They break up, and Felicity accepts the job with Adam