In the last episode of the series, death and terminal illness prove to be the keys to romantic success for Mark and Jeremy. Jeremy gets in with the Christians and Mark finds the perfect venue for a first date with Sophie - a funeral. Everyone's having a great time until the paramedics arrive.
Edina builds a panic room. Patsy is at her shop, Jeremy's, when Minnie Driver walks in. Minnie complains about not scoring any free stuff from other shops at Bond Street, and takes pictures of herself shopping to sell to the paparazzi. Patsy is determined to become Minnie's stylist, so she later invites Minnie to Edina's house. She has gathered racks of designer outfits with which to dress Minnie. When Minnie wants a necklace that Edina is wearing, Patsy wrestles Edina for it, and they accidentally lock themselves in the panic room. They believe they will be unable to escape for days because Patsy panicked and kept pressing the buttons on the keypad. While they are locked in, they play Trivial Pursuit over the intercom and camera with Saffron. They also discover that Minnie Driver has taken all the designer clothes. At the end, Edina and Patsy discover they were locked in for only a couple of hours.
Penny and her classmates experience culture shock when their teacher assigns them to spend time in homes of classmates of different nationalities. Penny's initial awkwardness when visiting a Pakistani family who's fasting during Ramadan gives way to an appreciation of the Islamic faith.
Finding difficulties training his interns, J.D. asks to Elliot for some help. She tells J.D. about Sean, who gave Elliot great tips based on his dolphin training that fit perfectly for her interns. Dr. Cox finds the ideal pediatrician for his son: Dr. Norris, who acts and looks just like him. However, Dr. Cox is quick to find a problem with him once Jack develops a cough that scares both him and Jordan.
When a 14-year-old violinist disappears on the night of a concert, the team follows her and her valuable violin's trail and Samantha bravely tries to recover from the gunshot wound.
A castaway has their work cut out for them when the decide to care for a sickly snake; a sixth contestant is voted out of the tribe.
On Emma's first birthday, Ross and Rachel convince everyone to delay their plans so they can attend her party, however plans go awry when Emma's birthday cake is revealed.
Kath and Kel are rattling around in that big house and Kath thinks Kel has genes to die for. Kim becomes gropable when Brett won't talk about his privates. Sharon has a calling.
Confident second-year resident Pratt wants to prove his abilities when he works the graveyard shift (11 p.m. to 7 a.m.), but his heroics sometimes backfire. Pratt shows contempt for a man, Ed Gamble, who presents no symptoms of disease but temporarily loses his speech.
Traveling on the road, the heroes encounter Nicholai, who had caught a Zangoose. While having a battle with Ash, Nicholai notices Zangoose is acting strange. Just then, Team Rocket appears, whose Seviper starts battling Zangoose and injures it. Due to Zangoose being Seviper's natural enemy, Ash decides to help Nicholai in training, to aid Zangoose in defeating Seviper.
Josh fails to sway an unruly congressman who insists on voting against the administration on the vice presidential confirmation, but Ryan reaches out to get him to change his mind; Leo fears that the potential defection of a prominent North Korean pianist will jeopardize secret nuclear disarmament talks; Will and Toby are humiliated when an early draft of a speech outlining their struggle to laud Bob Russell's confirmation is erroneously substituted for the final version; Donna's aunt and uncle from Wisconsin pay a visit, testing Josh's ability to refrain from bad cheesehead jokes during their tour of the White House; the staff struggles over how to language the state of the economy; fearing that the administration is drifting off-course, Toby wants to hand over more responsibilities to Will in order to focus on getting back to their core message.
The police and prosecutors investigate the connection between an award-winning songwriter and the young woman found murdered in his home to discover who would profit by her death at his hands.
Vanessa's parents come over the Kyles house to discuss the future baby's situation. Michael is outraged with the demands from the Scotts, but Calvin's size makes Michael think twice before taking any drastic measures. They take the Scotts out for dinner and are left with the bill. Realizing they have a couple of con artists on their hands, Michael and Jay stand up for themselves and set the baby's true needs – which don't include a new house for the Scotts as Calvin wanted.
Clark dreams he is being pursued by a frightened young girl who needs his help. However, after he discovers she is actually a comatose neighbor who should have woken up years ago, he enlists Lana's help to uncover the truth - which puts Lana in grave danger. Meanwhile, Lionel demands that Lex undergo a full psychological evaluation before he hires him.
The metrosexual fad has hit South Park thanks to the "Queer Eye Guys," and all the men in town are affected, except for Kyle and his Dad. Stan, Kenny, and Cartman give Kyle a makeover, and Gerald isn't far behind. Soon the women of South Park grow tired of the fad, as does Mr. Garrison.
A high-tech toy manufacturer uses military microchips to make his action figure toys more realistic. Unintentionally the toys start to think for themselves and are bent on world domination. In a B-story, Clover gets a new boy toy who caters to her every whim
The day-to-day lives of three orphaned children who are adopted by aliens that have trouble adjusting to the local culture.
During Vegas's latest Heat wave of triple digit temperatures, Gil and Catherine investigate a baby locked in a car. Warrick investigates a man dead of an apparent heat stroke in his house. Nick and Sarah investigate a woman's body found floating in the lake with a blow to the head.