The day-to-day lives of three orphaned children who are adopted by aliens that have trouble adjusting to the local culture.
In jail after his escapade at Ellen's party, Geoffrey is visited by the ghost of his dead mentor Oliver, who cousels him on the danger of trying to ignore his past feelings for Ellen, the woman who once broke his heart. Meanwhile, Holly and Richard work on their merchandising scheme, which involves a Shakespeare themed village of retail stores. Geoffrey is finally forced to fire Darren as director, to the relief of the cast but the worry of the Board of Directors.
Staff critiques vex Jack, who demands honesty and gets it, especially from servile Finch; a role reversal with Nina makes Maya a partygoer.
Matt and Sarah begin their student rotation in the ER, but get off to a bad start by arriving late and angering Dr. Norton, the attending ER physician. Matt and Sarah's relationship is tested when Matt quickly demonstrates an aptitude for the work, but Sarah accuses him of trying to make himself look better than the other students, especially her. However, Matt ends up looking foolish when he can't figure out how to turn off the ringer on his cell phone and he gets stuck fielding calls from his family. Matt's day ends tragically, leaving him to question his destiny.
Alan Shore uses questionable, if not illegal, tactics in representing his clients — Ted Grayson, a mentally unstable man accused of murder, and Karen Evanson, a woman who claims her husband's suicide was induced by a prescription drug.
The FBI worries that an upcoming march could be the target of a possible terrorist attack. Sue tries to enlist Betty's help in trying to capture her husband. Jack and the gang find where the Bubonic Plague was stored and how Joseph maybe spreading it. As Betty learns more about her husband she understands that Sue was right about him.
Hilary Duff and her sister Haylie impersonate two members of the Shangri-Las, a '60s girl group, in an episode in which the Vietnam War gets in the way of JJ and Beth, and Meg and Drew (Sam Page), when they go on a ""double date"" to Harrisburg, where Roxanne's friend Lenny is playing with his band. Meanwhile, Uncle Pete's drinking is getting in the way of his relationship with Nancy (Alicia Coppola); Helen is concerned about Will's state of mind as he recovers from his operation; Sam's getting interested in Malcolm X; and Patty makes a friend.
Malcolm skips out on Thanksgiving to go to a party; Reese becomes abusive to Hal and Dewey as he attempts to prepare Thanksgiving dinner.
The bludgeoning of a rich family patriarch has the detectives investigating several suspects, each with their own motives: his estranged wife whom he was about to divorce, a male friend of hers who was a parolee, their childrens' nanny, the victim's brother in law who is a doctor, even the oldest son. Goren and Carver call the family of suspects together to sort it all out... in family court.
When Sydney is taken into custody by the NSC, Jack and Vaughn have no choice but to ally themselves with Sloane to rescue her. But with only hours to spare before she is forced to undergo a radical surgery to recover her memories, they must put togther an extraction team, headed by freelance operative Brill (Richard Roundtree, "Shaft"). Meanwhile, Lauren faces an impossible choice -- side with the NSC, who she wants to believe is doing the right thing, or with her husband.
Realizing he's losing someone special, Charlie plans a Thanksgiving dinner to convince her he's a family guy and that she should be with him.
Bianca, a woman from the future, arrives to take Chris's powers, and Leo learns that she is actually part of an assassin family of witches. Meanwhile, Paige decides to move in with Richard, while Phoebe ponders joining Jason in Hong Kong.
Peggy overdoes it when she secretly slips Hank a testosterone supplement to combat his work-related stress. But he feels great, until he finds out.
The Wisdom Cube claims to hold all the known knowledge in the universe, but it seems he only possesses a knack for tiresome anecdotes. Frylock has his doubts if this is all for real.
Sam volunteers to go undercover to discover how rationed gasoline is being stolen from a fuel depot, and Andrew becomes a suspect in a murder case.
Space Ghost is angry about a variety of topics, and rants mightily to his guest, comedian Dennis Miller
Rita Sue teaches a newcomer a few tricks of the trade. Balthus is nervous about Tommy Dolan's allegations. Lodz gets approval from Management to help Ben.
Set in the 1960s, this British medical drama follows the staff and patients of St Aidan's Royal Free Hospital.