Dr. Abbott suspects that Linda and Andy like each other more than they should, so he decides to set his sister up with more appropriate suitors. Meanwhile, Ephram finally has the courage to tell Amy how he really feels about their relationship, but he is confused by his feelings for Madison, who comes to the rescue when Ephram needs help to pass his driving test. Meanwhile, Andy tries to help the soon-to-be-remarried Reverend Keyes (guest-star Tim DeKay) cope with his impending blindness, but the minister would rather leave his fate to God than attempt a new treatment that might save his sight.
The two young owners of a city bar are gunned down after hours and another man is wounded in the attack, which was allegedly committed by a masked gunman. Meanwhile, Calleigh's dad announces he is now a public defender and needs her help with a murder case in which a woman allegedly stabbed her boyfriend to death in his car with a screwdriver.
Hoping to prove herself to her father, Dee Dee goes against his wishes and tries to personally handle a tenant who has failed to pay rent for the last few months. She must come up with a new plan of attack after the man retaliates by threatening to expose several building code violations involving Dee Dee's apartment. Meanwhile, Mona reluctantly takes her mother out on the town. She feels crowded when Phyllis begins showing up regularly at her hangout and playing matchmaker for the patrons.
Maya learns that tuition has increased substantially, and she doesn't have enough money to cover it. William tries to give her the money by pretending she has received it from the firm's continuing education plan, but she turns him down. Lynn housesits for Joan so that her DSL can be installed while she is away with Brock. Lynn claims that she is going to work on a grant proposal for another documentary, but gets nothing done. Joan refuses to let her stay at the house, and Toni and William also reject her. Maya agrees to let Lynn move in for a month if she pays rent. Lynn proceeds to lie around and do absolutely nothing. Maya pays her tuition, but learns that her credits do not transfer and she must start over again as a freshman. She is unbelievably frustrated and breaks down in tears. Lynn annoys Maya by complaining about her own plight and claiming to be depressed. William tells Lynn what Maya is experiencing and convinces her to be more sensitive, and also to take action
Wiegel steaks out her own house by putting her dead stuffed cat on her own lawn. Her plan is to catch the kids who keep coming into her yard and playing pranks. Jones dies and the cast watches his tape that he made just in case he did die. The tape after revealing things about everyone tells them how Jones would want them all to drink 10 shots for him. Clementine Johnson goes to a vandalism call and finds gothic teenagers. She talks to them and tells them how there is no Satan.
Dylan plays a dangerous game against two gamblers, but not everything is as real as it seems.
Sasha, Bosco, Sully and Ty get on the case of a malicious rapper. Ty considers returning to law school with the help of Sully. Jimmy struggles with his new position and his relationship with his co-workers when he makes a big mistake during a fire drill. Faith gets a physical therapist.
When Jimmy gets accepted as a contestant on Big Brother, the thought of him and Christine having enough money to get their own place makes Greg takes drastic measures to see to it that Jimmy wins.
When Experiment #601 is activated, things are looking bad, as he is beating up the islanders. Stitch is ready for it, but when he eats the combination of a left tennis shoe and macadamia nuts, it creates a toxic poision, which erases all of his super abilities. Now Lilo has to retrain him from scratch, but Stitch doesn't like the idea.
The Mutant X team must stop a serial killer who leaves clues to his next victims in the form of puzzles.
During his Sunday sermon, Eric proposes that instead of a financial contribution, everyone should make a commitment to reach out and help someone in need. Kevin suggests that he and Lucy work together to set up a neighborhood watch program, but she feels passionate about working with Habitat for Humanity. Eric calls his new son-in-law Carlos (guest-star Carlos Ponce) and asks him to fly in without Mary for dinner with the family, which makes Carlos very nervous. Also, Ruthie picks a shy new girl at school as her project and soon finds out that she has a secret. Meanwhile, Peter picks Ruthie as his project, which prompts her to tell him that they should spend less time together. Chandler and Roxanne keep running into each other stirring up old feelings. Lastly, Annie becomes jealous of all of the time the twins are spending with Cecilia.
Debra persuades Ray to hire Gianni to do some remodelling in their kitchen, but they both soon regret it due to their friend's laziness.
Professor Oglevee goes on a dating game show where America will choose one of four fine--yet somewhat freaky--women he'll go on a date with. To his horror, Nikki swindles her way on to the show as one of his potential dates. Meanwhile, Kim, Stevie and T open a smoothie stand on campus, but after several failed attempts at finding the right flavor, Kim stumbles upon Grandma's delicious and quite intoxicating secret formula.
Shake puts together a metal version of the "Birthday Song" hoping to cash in on the royalties. But, when Zakk Wylde come looking for his cut of the money, things go all wrong for Shake.
Alan and Charlie have encounters with some highly libidinous soccer moms, but with two very different outcomes.
When a bookkeeper goes missing, Goren and Eames are led back to the death of her brother, a hitman, two years earlier. An imprisoned mobster seems to be their best bet, but when another body turns up it takes the case to a whole new level.
Lilly re-investigates the case of a murdered church organist, when his Alzheimer's-stricken widow begins having flashbacks of the night in question.