Mulder and Scully have 24 hours to save A.D. Skinner from being killed by a biologically engineered disease. The disease appears to be created by a shadowy government organization, but in order to save Skinner's life they must determine who wants him dead and why. With Skinner's condition worsening, Mulder seeks assistance from Senator Matheson, who he hopes can provide some answers and help him to find a cure.
Jackie dumps Kelso after he makes out with Pam Macy and invites everyone but him to her parent's ski cabin for the weekend. Eric, excited about what this could mean for him and Donna, pays no attention to Kelso's whining about being left behind or Red's tips about driving in the snow. He doesn't realize that Hyde keeps hitting on Donna and Kelso plans on following them to the lodge. Also, Kitty gets mad at Red over a past indiscretion and Fez has his first experience with snow.
Desperate to open the loft portal and re-connect with Shelly, Draven dabbles in magic, unleashing a terrible force that even he may be incapable of overcoming. Desperately lonely, Draven attempts to re-open the loft portal door using ancient incantations. He believes he is successful when the door energizes. However, what emerges is not his beloved Shelly but the beast-like, evil force of executed serial killer Richard Lee Wilbanks (Lawrence S. Smilgys) who has been waiting for an opportunity to return and wreak vengeance on everyone who saw him die. He easily overpowers Draven, who loses his regenerative powers in the devastating fight. When several of those who were present at Wilbanks' execution are violently kidnapped, Detective Albrecht and his new partner, Capshaw, are assigned to the case. Draven confesses to Albrecht that it was he who unleashed this terrible force and when Cordelia, who was an Assistant D.A. at Wilbanks' trial, is also kidnapped, the rift between the two men s
Percy is let out of prison and joins a militia group – the same crew that the Spencer's uppity neighbors, the Bensons, have hired to kill them. On their way to the liquor store to make the hit on Anastasia, Percy manages to rat out the militia group and save his wife.
Judge Roberta Kittleson, presiding over a case Bobby's working on, informs him that she's had an erotic dream featuring him and proceeds to inquire whether he's interested in her. Bobby responds negatively and worries that it affected Kittleson's judgment when ruling after ruling goes against his client. Helen prosecutes a TV newsmagazine producer as an accessory for murder after he inadvertently encourages a Kevorkian-like suicide doctor to capture a death on videotape. Lucy teaches Eugene's son, Kendall, to dance.
A dejected Yvette decides she needs breast augmentation after another actress is picked for a plum stage role. Meanwhile, T.J. is harassed by bullies who make fun of his ears.
To flush out Vacek, Operations and Madeline order Michael to poison Elena, but Michael can't bring himself to do it. So Section poisons Elena anyway, while Michael is out on a mission, and her survival will depend on whether Vacek has enough conscience to visit his daughter in her time of need. Meanwhile, Section moves sleazy informant Mick Shtoppel in as Nikita's neighbor.
The girls push Tyreke and Jordan to push for a calendar photo-shoot.
Scapegoated for the vandalism of drunken Isotopes fans, the children of Springfield wage war on the adults by broadcasting their secrets on the radio.
With acting boss Jackie Aprile dying of cancer, Tony prepares for a power struggle with Uncle Junior. Christopher and his associate Brendan make trouble for themselves when they jack a truck full of DVD players. Tony's mother Livia finally agrees to live in a retirement community. Big Pussy and Paulie Walnuts are sent to find a stolen car.
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Superman comes to a planet under the control of the Phantom Zone prisoners Jax-Ur and Mala, but feels he cannot interfere.
T.J. and Vince manage to convince everyone that the bad haircut they gave Mikey is actually cool.
Harley reflects on her first meeting with the Joker as she plots to eliminate her main competition in his attentions—Batman.
When Trent is beat up and stabbed, the only witness is a mentally changed girl. The rangers try to have her ID the attacker.
The Tomassitron Matter Amplifier grants Jay, Kay and Elle super powers as well as three alien criminals, leading to a super showdown.
Hercules, Morrigan and Nebula return to Corinth to confront the evil Dahak, who has possessed Iolaus' body.
Follow Herc's many labors during the years he spent training on how to be a hero under the tutelage of satyr Phil. Many of the Olympian Gods and Goddesses pay visit to the young hero-to-be and help or hinder him in his new adventures.
An old ex-cop with an outdated driver's license starts his car and Gary crawls on it to stop him driving. Two Italian tourists are robbed by fake taxi drivers. The tourists charm Erica to show them old Chicago buildings, and Capone's last living major gang member is released from prison.