Despite the sadness that she feels, Denise finds the strength to be there for Jeremy’s friends when they need her most. Things are tense between Roxy and Trevor as she struggles to find a way to tell him about the truck stop. Roland and Joan are determined to do whatever they have to do to adopt a baby, but a situation with one of Roland's patients leads them to consider other options.
Homer opens his own hair salon after discovering he is a talented stylist; Milhouse professes his love for Lisa.
Paul begins to suspect that Susan is responsible for his rapidly declining health; Lynette and Tom butt heads over where to go on their family vacation, as well as which one of them will set it up; Gaby shows Juanita a horror movie and has to pay the price when her daughter becomes too scared to sleep in her own bed; and Bree runs into some trust issues when she goes out on a date with a detective.
The invasion by King Charles of France and Della Rovere proceeds with victory seemingly inevitable as the French sack the city of Lucca and the Italian powers flee to their banner, with Lucrezia's husband Giovanni Sforza poised to join them in the name of Milan; inventor Leonardo Da Vinci (guest star John Lynch) shows his drawings and blueprints for war machinery to the invaders.
Stewie and Brian go back in time to stop Bertram from killing Leonardo da Vinci in order to erase Stewie from the universe.
Bob and his family are forced to spend the weekend at Mort the Mortician's while the restaurant is being de-molded. Linda and Bob double date with Mort and a female mortician he meets online while Tina babysits Gene and Louise in Mort’s crematorium.
Eddard investigates Jon Arryn's murder. Jon befriends Samwell Tarly, a coward who has come to join the Night's Watch.
After Jeanie Long commits suicide, evidence comes to light exonerating her for the murder of teenager Abigail Mantel 11 years earlier. DCI Vera Stanhope and her team set out to retrospectively solve the killing, delving into the secrets and lies of a small community which still feels the repercussions of Abigail's death. Then the case takes an violent and unexpected turn - can Vera use her skill and instinct to find the truth and lay ghosts to rest?
To celebrate Christmas, the Browns head off to a snow-bound cabin in the mountains to get away from the pressure of their ongoing police investigation. And later, a decision will be revealed that will affect the families lives once again.
The Sister Wives struggle to accept that this will be their last Christmas in Utah; a massive change to the family dynamic.
Sketches include Osama Cold Open, Mother's Message Monologue, GOP Debate, Mermaid, An SNL Digital Short: Jack Sparrow, Weekend Update, Birthing Class, Bedelia - Sleepover, Pregnant in Heels, Discount Prom Wear, and Hallmark Mother's Day.
Big bluffs, big pots, pocket aces, and angles? Johnny Chan, Phil Galfond, Antonio Esfandiari, Robert Croak, Erik Boneta, Bill Klein, Phil Laak, and Doyle Brunson continue to battle on this episode of High Stakes Poker.
The Joes uncover a deadly Anaconda Strain virus while searching for a missing scientist and learn of Cobra's plan to profit from the sale of its antidote.
After being thrown into a portal by Dark Surfer, Hulk ends up on Sakaar and he is captured by the Red King for gladiator-themed tournament games. In order to be free of the Red King's cruelness, Hulk teams up with two other gladiators named Miek and Korg.
Five teenagers inherit samurai powers from ancient Japan to protect the world from an army of monsters.
The TARDIS is marooned onboard a 17th-century pirate ship whose crew is being attacked by a mysterious and beautiful sea creature. Becalmed and beset by cabin fever, the pirates have numerous superstitious explanations for the Siren's appearance. The Doctor has other ideas but, as his theories are disproved and every plan of escape is thwarted, he must work to win the trust of the implacable Captain Avery and uncover the truth behind the pirates' supernatural fears – and he must work quickly, for some of his friends have already fallen under the Siren's spell...
Owen is having a hard time with the boring discipline of Grandpa's teachings. When he recognizes that an old friend is part of the dangerous Subsiders parkour crew, Owen infiltrates their underground lair to save him. Meanwhile, Mike and Amanda cope with the temporary loss of their partner and friend.