Libby lends a helping hand to Hurley to support him when he begins to think the island is having a strange effect on him. Hurley begins to see Dave (guest-star Evan Handler, Sex and the City) on the island, who was his friend in the mental institution Hurley was in. Also, Locke's sense of purpose is shaken when the prisoner gives him new information about the hatch.
Cartman and Kyle are at war over the popular cartoon, Family Guy. Kyle loves it and Cartman hates it. When the show airs some controversial content the boys go on a cross country chase with the fate of Family Guy lying with the first boy to reach Hollywood.
Jonas and the team carry out an assasination of a terrorist in Spain. However, they soon find out that the government called off the mission and will now not protect them in the country which means there only hope is to escape. Back at the base, Molly learns that her daughter Betsy wants to drop out of college and Kim thinks about taking a college course herself.
A teenage heart transplant patient is rushed to the hospital when she has an allergic reaction while living in a "clean" room, and House and Wilson work out the kinks of their new living arrangement.
Rory forgives her beau. Luke's girlfriend is secretly upset when he spends a few days with April. Rory does some spying on her mother's behalf.
Gibbs and the team are called in when a couple of kids stumble upon the body of a missing Marine in a frozen lake. As the NCIS team search the frozen lake bed for clues, they come across three more bullet-ridden bodies.
A manhunt ensues when Victor Paul Gitano, a recently released sex offender, kidnaps two children after killing the rest of their family. Benson and Stabler pursue Gitano only to find their own relationship challenged as both experience opportunities where they put their personal relationship ahead of their job. After having her throat slashed, Benson requests for a new partner when she hears what Stabler has to say about their relationship and their job.
When J.D. rearranges his schedule to allow himself more time to spend with Turk, Turk secretly resents hanging out with J.D. in that time because it interferes with his own "Turk Time." Meanwhile, Dr. Cox and Jordan go on a double date with Elliot and Keith, and Carla covers for Kelso at work, as he grieves for his dead dog. Later, a patient almost dies, after giving up part of his liver for his brother, and the hospital staff learns about making sacrifices for the people they really care about.
Moz is a drug dealer and has very strange clientele who come and go from his flat.
Three old men from Yorkshire who have never grown up face the trials of their fellow town citizens and everyday life and stay young by reminiscing about the days of their youth and attempting feats not common to the elderly.
Jack and Wayne locate a source inside Logan's administration who has information on Palmer's assassination. But things get complicated when they learn that Henderson is using leverage to keep her silent. Audrey is forced to choose between Chloe and Buchanan as Homeland Security begins to absorb CTU.
Flashbacks shed light on the past actions that led to the incarceration of Lincoln, Sucre, T-Bag and C-Note. Basis of Michael's ingenious break-out plan are revealed. Dr. Tancredi memorizes how she ended up in Fox River State Penitentiary.
After 10 dates, Christine faces a critical moment in her relationship with Burton. Will she or won't she? Let him in the house, that is, to meet her son, Ritchie. She eventually relents, only to be thrown for a loop later.
Erin and Jacob Harmony are at their wits' end raising three boys -- Jake (11), Ian (5) and Grant (3). Big brother Jake is not the big problem, but his two little brothers are. Ian is the master of back-talk. He torments Grant into frenzies, and the two have violent battles. Grant's temper gets so out of control that he bites furniture until he bleeds from the mouth. He has major separation anxiety, and has been known to follow Erin's car all the way to the highway when she tries to leave the house. On top of it all, Grant wakes up at 3:00 a.m. every morning and insists on sleeping with Mom. Dad gets so fed up with the crowded conditions that he moves himself onto the living room sofa! With discipline attempts going nowhere and no one getting any sleep, this family needs Supernanny now. Can Jo restore harmony to this household?
Wildfire competes with Dani's horse Ishmael for a Breeders' Cup slot; Kerry rekindles his romance with Gillian.
Annie and Ruthie spend the day together to unwind, while Lucy's world becomes complicated by both professional and personal news, and Eric unintentionally shakes up things between Rose and Simon.
The comedy illusionist duo explore various topics and debunk what they consider misconceptions about them.