Jude finds himself a new goldfish friend named "Fish". Meanwhile, Nikki snaps at Caitlin, after Caitlin keeps telling stories to her friends about her new crush, Wade, which leads to Caitlin and Nikki being no longer friends. After the gang is forced to take sides they try to get Nikki and Caitlin back together.
Gina is planning a family Thanksgiving. Joey and Zach discover some ancient Native American artifacts on Joey's property and mistakenly give them away.
Earl tries to cross of number four off his list “Blew dad’s chance to be elected mayor”. Four years earlier, Carl Hickey ran for mayor to redirect a proposed airplane traffic route over his house and away from the wealthy part of town. Earl unfortunately ruins any chances of his father winning when caught in on tape assaulting a police officer. Earl must now help his father get elected and mend his relationship with his father.
Michael starts monitoring the emails sent out in the Dunder-Mifflin workplace, upsetting the employees. Meanwhile, Pam believes that the relationship between Dwight and Angela is more than just worker to worker, Jim throws an office BBQ at his house in order to show his roommate the kinds of people he deals with everyday, and Michael, after annoying everyone at his improv classes, crashes Jim's party with a terrible karaoke number.
A death row inmate asks for Booth's help to prove his innocence before he is scheduled to be executed. Booth agrees and asks Brennan and her team to help him out.
A patient with AIDS stalks House to get him to take his case; House and Stacy stalk a mouse in her attic; and Cameron faces a health scare of her own.
Rory's long-absent father reappears in her and Lorelai's lives, casting uncertainty on what this will mean for Lorelai's current relationship.
This episode demonstrates the production processes for kitchen knives, mannequins, socks and hypodermic needles, and shows how each is made.
Sam and Dean investigate an abandoned sanitarium and discover that when the hospital was open, the patients held a revolt against the cruel and unusual punishments inflicted by the head doctor. While the brothers search the premises for four lost college students, the tortured spirits cause them to go insane, turning Dean against Sam.
Tony is accused of murdering a woman whose body was found at Quantico and the team must prove his innocence.
After sixteen-year-old Lauren Westley loses her unborn child due to a severe abdominal beating, her father's insistence that Lauren was raped leads detectives to the baby's father, but it isn't long before the detectives realise that Lauren was an active party in her own beating, and the two teens had found it necessary to take the steps they did because the abortion clinic kept putting off Lauren's request for an appointment. Novak faces a tough opponent in her own office when she and Branch disagree over the appropriate action to be taken against Wayne Mortens, the young girl's boyfriend.
Christian still has second doubts about the wedding. Gina tries to convince Kimber to leave him. Matt's new girlfriend compares plastic surgery to the work of the Nazis.
It's Thanksgiving time. The rumored news about Martin being an expectant father has finally been let out of the bag. At school, everyone thinks that Ruthie is the one who is pregnant with Martin's baby, as she was previously out of school for awhile with
The Montecito hosts a comic book convention. Mary is checking into the Montecito for a while. Sam is after the black book of one of the world's greatest casino hosts, who just died. Monica wants Danny to be less like Ed. Danny is worried about the Montecito and calls somebody behind Monica's back.
Michael sees proof his plan is working, so he begins to overcome the last obstacle. As the escape draws near, the group tries to reduce its number by one and targets T-Bag.
As Ben, Regina and Oliver gather at Lydia's for Thanksgiving, they recall all their disastrous past Thanksgivings which include the year they found out about Regina's sexuality and the year they found out their parents were breaking up.
Ted and Robin are surprised to run into Barney when they volunteer at a homeless shelter on Thanksgiving. Lily is on the brink of freaking out when she goes to Thanksgiving dinner at her future in-laws house.
Allison is lead to an art gallery where she encounters the art of a popular artist. While looking at some of his paintings 3-dimensional images emerge that make her believe that the artist is somehow involved in a crime. Joe gets a job offer from a former co-worker. – this episode is partly in 3D