When Krypto and Streaky meet up with a fire Dalmatian named Smokey, who has the worried of a new puppy on his mind. Streaky assumes the new dog is a Smokey "replacement", much to Krypto's disbelief. Streaky gets the bright idea to use Krypto as Smokey's super-double.
When Jerry WOOHPs the girls right in the middle of a homegrown mani-pedi (courtesy of Clover, see b-story), they know it must be serious... and it is. Jerry informs the spies that fellow teen spy hottie Britney (from ""Alex Quits"") has crashed in a WOOHP chopper on a remote island in the middle of the Atlantic Ocean. Jerry explains to them that the island is a top secret holding facility for WOOHP's most dangerous baddies (humans, robots, mutants, aliens, you name it)! Just when the girls think things couldn't get any worse, Jerry informs them that Britney's chopper destroyed the island's security system when it went down -- and now the island's ""residents"" are running totally wild. And one more thing: the girls only have a few hours to save Britney before the island self destructs! In a b-story, Clover becomes a ""Beautylicious Betty"" -- a peddler of overpriced, shoddy beauty products that eventually enrage all of her customers.
Greg and Jimmy have a not-so-neighborly war over Jimmy wanting to cut down a lemon tree in his backyard that Greg is attached to.
After Stu sells an invention, he tells the kids that he's splurging on a built-in swimming pool. While digging up the yard, the construction crew unearths the Rats' old mechanical Reptar toy. The kids fondly remember it, but decide to throw it away, until, during an electrical storm, they become convinced that they've angered Reptar. They ultimately decide to rescue the toy, and realize that, although they're growing up, they can't forget their past.
When the body of a young woman is discovered at a laundry facility, the bed sheets she is wrapped in lead Mac and Stella back to an upscale New York hotel that houses diplomats from around the world when the United Nations is in special session. Meanwhile, Danny and Aiden investigate the death of a homeless man found dressed as a human statue. By all accounts, the prank is deemed a misdemeanor, but Danny decides to delve further and his refusal to stop the investigation puts him at odds with Mac.
The bludgeoned corpse of a promiscuous lawyer is found in her office and detectives treat her former lovers as suspects until DNA evidence points to a co-worker. This crossover continues on Law & Order: Trial By Jury S01E08 Skeleton (II).
The team investigate a suicide case, believing that the main reason of her death is a nervous breakdown, but Ducky believes that she was actually murdered. FBI Special Agent Fornell helps them in the investigation. The team discover that the dead woman was involved in a love triangle and that this may have contributed to her death.
A series of fire drills leads Veronica to discover that Neptune High has been receiving bomb threats, so she enlists Wallace and Mac's help to investigate classmates who could pose a serious threat to the school, including new student Ben. Meanwhile, Keith stuns Veronica with the news of who he's been secretly dating. Later, Duncan confronts Veronica about her ongoing investigation into his sister's death.
J.D. and Carla get the silent treatment from Turk, who can't seem to control his emotions, after learning about their kiss. Dr. Cox reluctantly seeks the help of Elliot, when an epileptic patient won't listen to him. The Janitor feels emasculated by his new uniform. Jordan trys Botox.
A tip from Lemonhead's juvie would leads Vic and Monica to take down a major heroin operation with connections to Antwon Mitchell. Monica continues to battle Aceveda as she tries to sell her new policies to the community, and Julien begins to doubt her methods. Claudette loses trust in Dutch when she suspects he made a backroom deal with the D.A. And Shane and Army find themselves over their heads with Antwon when he blames them for Vic's heroin bust.
House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.
Michael arranges a morale-boosting birthday party for Meredith and is determined to come up with the funniest message in her card. Dwight wants a pact with Jim to fight the downsizing, and Michael regrets showing off when Oscar asks for sponsorship for a charity walk being undertaken by his nephew, who has cerebral palsy.
George gets caught up in some bad family ties when he lets Vic give him money to go out on a date with his sister.
Jim and Cheryl adjust the clocks to get the kids to bed earlier so they can have more quality time together.
The team visit an ancestral home on the Cornish coastline with a history of murder, suicide and treason.
A family drama focused on three generations of women living together in Hartford, Connecticut.
Alan is busy receiving a big delivery at Hooper’s Store so Miles helps him out by watching the fruit stand. Elmo and Zoe walk by talking about cookies and ice cream. All of sudden, Sesame Street is transformed into a 50’s musical show “American Fruit Stand.” Miles sings “I Love Fruit” (to the tune of “I Feel Good”), a song about how good fruit tastes and how good it is for the body. Elmo and Zoe get so excited about fruit that they now want an apple and an orange! Gina comes to the fruit stand and asks Miles for some peaches and pears. Sesame Street is transformed once again and Miles sings, “Peaches and Pears” (to the tune of “Twist and Shout”). Maria needs some broccoli. It happens to be her lucky day because broccoli is a special guest star on “American Fruit Stand” and Miles sings “Broccoli is Good” (to the tune of “Johnny B. Goode”). All of the fans and groupies become so excited about fruits and vegetables. Alan’s business has never been so good.
The whole school has caught Yu-Gotta-Go fever, a role playing card game, except Chuckie. When he finally starts playing, it becomes an obsession, and he's hired by Angelica to do her chores in exchange for more cards. He becomes one of the school's elite players, but in the pursuit of an elusive card, he nearly parts with the valuable stamp collection that Chas has passed down to him. It's up to his friends to keep him from getting in over his head.
When Jr. wins a national competition for his cartoon entitled ""My Wife and Kid"" -- based on himself, Vanessa, the baby and the rest of the Kyle family -- it catches the attention of ABC. Michael becomes Jr.'s agent, but the meeting with the television executives goes badly, crushing Jr.'s dream opportunity, so now Michael has to find a way to rectify the situation. Meanwhile, Claire threatens to break up with Tony unless he can bring some ""umph"" into their relationship.