A major food fight is raging in the cafeteria. Principal Tweedy walks in and sees Lizzie, Kate Sanders and Larry Tudgeman right in the middle of things and calls them to his office. For punishment, the three will have to clean up the huge mess and do some community service.
A cancer patient, who was growing marijuana in her apartment and selling it, is found raped and murdered, sending the detectives on a hunt for two middle school students, each blaming the other.
Wakeman has to be out of town on the weekend of the annual Minutian invasion. She has just the weapon to repel them but she's doubtful her daughter can keep track of it in the disaster area she calls a bedroom.
The Finsters' puppy is ill, and the babies think it's because she hasn't been named properly, but pet psychologist Dr. Mutterly thinks otherwise.
Dee-Dee has a new boyfriend who also likes science and Einstein, and soon the boy finds himself caught in a vicious tug of war...
Dexter is hit by a wrench while working on a device, and suffers amnesia, Dee Dee decides to mess with his head
Dexter and Mandark drill underground to expand their labs, but end up overlapping each other's work. They secretly devise a plan to destroy each other.
Reba begins to feel more comfortable in her relationship with Brian so she bravely invites him home to meet her family. Meanwhile, Brock and the kids are less than enthusiastic after they learn they have to attend Barbra Jean's family reunion in Fisheye Bottom. At the reunion, Brock runs scared of Barbra Jean's gun-toting father, Big Daddy, and Barbra Jean finds herself the butt of the joke when it comes to her older sister and brother-in-law.
When Holly's father is transferred to Japan, she is sent to live with her big sister Valerie in New York City, turning Valerie's life upside down.
Daffy and Melissa stick together to play impractical jokes on the others. To get even, Lola demonstrates the consequences of an impractical joke to Daffy and Melissa.
Melissa gossips tales of Taz to the others, whilst Bugs has doubts and tries to prove they aren't true. After proving Melissa wrong, she confesses her fibs.
The Hansen's gather for Thanksgiving to show Owen how Thaksgiving is done in the Hansen family. Also Syd misses her wedding shower because of working all weekend.
Abby's family nightmare continues as she and her mother Maggie search for Abby's missing brother Eric, who Abby suspects is suffering from serious mental problems. Meanwhile, Corday treats a family of patients who, while building a snowman, were severely injured after being struck by a truck driver.
As Dr. Hill closes in on the homophobic psychopath, he almost falls victim to him, or her. Who can tell?
Team Rocket's failed attempt to catch Pikachu has left the little yellow Pokémon dangerously ill. Littleroot Town has no Pokémon Center so Ash turns to Professor Birch for help. Professor Birch thinks that Pikachu can be cured—but first they'll have to catch it. Delirious with fever, Pikachu has run off into the forest. Meanwhile, a girl named May is also going to see Professor Birch in order to receive her first Pokémon. She arrives just in time to save the professor from a pack of mad Poochyena. Before he can explain why he's running around in woods, Professor Birch runs off in search of the missing Pikachu. Time is running out and Pikachu is in danger of exploding. In a twisted turn of events, Team Rocket's latest Pikachu-catching contraption ends up saving the day.
Rachel's sister Amy tags along for Thanksgiving at Monica's place, because her (married) boyfriend cancels their plans. While watching the parade, Joey realizes that he forgot to show up for the Days of Our Lives cast float, and he asks Phoebe's help to come up with a believable lie. The dinner goes fairly well, however, Monica constantly obsesses about anybody damaging her best china. To make matters worse, Amy comes up with a crazy scenario involving Emma, which sparks a massive argument among the gang.
While Granny is recovering from a foot bunion, Lola takes charge. The babies soon get tired of Lola's decision making and they tire her out.
Thinking it's the right thing, Lola tells on her friends for any misbehaviour. In response to her telltale antics, the babies refuse to play with her, but Lola settles the matter with an apology.