In the second season premiere, we return to the Walker family, who have a variety of different problems. Nora is now keeping a blog on Iraq. Meanwhile, a friend of Holly's flirts with Kevin, unaware that he's gay. Kitty is given advice on how to act now that she and the Senator are engaged.
Peter convinces Brian to move in with his girlfriend Jillian and Stewie tags along to help pay the rent but he tries to interfere with their relationship. Meanwhile Meg and Chris get jobs at the convenience store where Chris befriends the manager Carl who leaves Meg to do all the work. Carl soon fires her and promotes Chris to the co-boss.
A monster-like robot is accidentally released into the hotel, due to the twins. A Halloween party is thrown by London. A typical prank.
To impress a girl, Bobby protests against soda machines in the school. However, since the teachers have been using the drink machine money to pay for their "retreat", they decide to fight back. Meanwhile, Dale decides to record his friends' witty quotes and put them all in a book.
Killface recovers from the latest assassination attempt, which was not Val this time. Xander continues to try to contact Fred Dryer, but his campaign may be derailed.
Things are really beginning to heat up for Dexter: Doakes' suspicions about him are growing, his victims are escaping, and his body dump site has been found. Meanwhile Paul is troubling Rita over the missing shoe and Debra is going through trauma over the Ice Truck killer incident.
Toki Wartooth is fed up playing in the shadow of Skwisgaar's lead guitar. Under the tutelage of a crusty old guitar master, Toki learns that the heart, too, has strings.
Susan learns that she is expecting a child while Bree continues to fake her own pregnancy. Gabrielle begins an affair with her ex-husband, Carlos and Lynette tries to conceal her cancer from her friends and children. The episode also introduces Katherine Mayfair, Susan's old friend who returns to the neighborhood after being away for 12 years.
A freak accident gives Homer an operatic singing voice, and he becomes a star at the Springfield Opera. But with fame and fortune comes a price: He's continually bothered by fans, an obsessed woman in particular.
Francine demands that Stan take the family on a vacation after she learns all of their previous vacations never actually happened: The CIA had planted artificial memories of the "vacations" in their brains so Stan could ditch them. Meanwhile, Roger wants to be a thespian.
In order to celebrate Otis' birthday the animals trick Farmer into going to Turnip-Con for the weekend. However his plans hit a snag when that very same weekend the Beady's nephew, Eugene, comes for a visit.
Carly's grandfather comes for a visit and is appalled by Spencer's unusual behavior, so he questions Spencer's ability to be in charge. Carly must convince him that Spencer is capable of being her guardian.
After Johnny and Dukey send Bumper packing, they start to come against each other in a game of "Say Uncle".
Yeah, Kenichi’s a total wimp. He’s always getting picked on and doesn’t have a lot of friends to stick up for him. The guy needs motivation if he hopes to graduate in one piece. Well, Miu’s the perfect motivation. She’s hot, she accepts him, and she just so happens to live at a dojo with six martial arts masters. You could say fate has led Kenichi to their door, or you could say he was just following the hottie. Either way, he’s about to get whipped into serious shape. If he can survive some hard-core training, he might survive another day at school. He might even score with Miu. Yeah, you could call Kenichi a wimp. But let’s go with underdog instead.
During a confrontation with Diablo, Johnny is exposed to a potion that makes him more powerful. Unfortunately, the potion also begins to turn him evil.
When Kiwi's mindless destruction becomes too much for the group to bear, they force Odd to keep him at the factory. As Odd drops him off, XANA possesses Jeremie's Kiwi Two robot, turning it into an army of self-replicating attack dogs. The dogs attack Yumi and Ulrich, among other children, during Jim's Pencak Silat class. After Aelita deactivates the tower and a return trip erases the incident, the group decides that the regular Kiwi isn't that bad, after all.
Tom and friends face their greatest Chaotic challenge ever – the all-powerful, all-terrifying, all-destructive Allmageddon Attack. The only hope to combat this fearsome force lies in a crazed creature named Hoton. Can our heroes find a way to stop the unstoppable before Peyton gets Allmageddoned? Little do they know, Peyton has a plan to beat it.
After a deceased relative of Zoey's sends her tons of boxes of ribs, Zoey, Chase, Micheal, and Logan agree to have a rib cook-off. After a fierce feud between Micheal and Logan, they decide to compete against each other with Zoey on Micheal's team, and Chase on Logan's. Quinn accidentally blows Mark's eyebrows off in an experiment gone awry.