Fission City has suffered a blackout as Dr. Paradigm unveils the Wolverinepedes (a wolverine/centipede hybrid) which will be a solution to Fission City's toxic waste problems. The Street Sharks are contacted by Paxel of the G.E.C.O.s (short for Genetic Engineered Cave Organism) on behalf of Robert Bolton where they learn that toxic waste is leaking into their underground home beneath the garbage dump. The Street Sharks discover that the Wolverinepedes are a cover for Dr. Piranoid's illegal toxic waste-dumping property where the Wolverinepedes have been getting bigger from the consumption of toxic waste.
Ros, Ed and Beckett's first customer appears in the form of Irene Campell, who turns out to have conned Beckett into helping her continue doing her business. Roland Blatty, a friend of Ros' who own the new Bureau of Weapons is trying to put a stop to the devices Irene sells, which have killed countless people. The team race against time to stop Irene and her legal adviser, Morasco and at the same time save Ed from a microbe that is killing him.
With no child-protection laws, and influenced by Charles Darwin's theory of evolution, Mike has a girl removed from her ""guardian"" by taking the man to court and trying him for animal abuse. Mary Ann: Doren Fein.
Two diametrically opposed brothers, wrestle for control of a million-dollar pharmaceutical company. A vaccine that could hold the secret to eternal life, becomes the object of the brothers' bitter struggle.
When Jill is found guilty of physician-assisted suicide, Wambaugh insists that Judge Bone put the issue of euthanasia on trial. Meanwhile, Kenny and Carter discover that Zack has been killing swans in a nearby pond.
Don’t panic, but germs are all around you. Germs are bacteria, viruses, protozoa, and fungi, very small one-celled organisms. Your skin keeps most of these organisms from ever getting into your body. If germs slip inside, your body has some powerful weapons to attack and destroy them. And not all germs are bad; there are good germs, too, like the ones that live in our stomach and intestines – our guts.
Ray gets testy with Lisa when she pulls the twins out of school for a day of fun - just as they're about to take a big history exam.
Ed resents Maurice's advice about his relationship with Heather. Chris believes that Maggie needs a new bowling partner so he holds tryouts and gets the woolly mammoth professor to be her partner. Michelle's success at bowling threatens Phil; they fight about it and she moves out. Chris becomes jealous of Maggie's new partner. Lester's wants to produce Ed's script for "The Shaman" with one change that makes Ed think about what Maurice said to him. Michelle moves out of the house.
Rachel and Barry start dating again, which is kind of awkward since he's now engaged to Mindy, who wants Rachel to be her maid of honor. Meanwhile, Chandler goes nuts when a woman he likes won't return his phone calls.
Jerry's family lives it up at the Plaza for free, thanks to Elaine; the fumigation of Jerry's apartment disables Kramer's taste buds.
Martin and Gina bite off more than they can chew when they invest all their money in a restaurant, (named Martin's Meatloaf & Waffles), that becomes more popular than they anticipated. The problem is that neither one of them knows how to run a restaurant or manage the finances, AND they take on Stan as a partner, which leads to lots of hilarious situations along the way.
Deb and Carter compete furiously for procedures after Benton announces their books are due a week earlier than previously announced. Deb commits a nearly deadly error on a patient while trying to keep up with Carter. Doug's relationship with Diane Leeds grows. Peter and Jackie decide to put their mother in a home. Dr. Greene is put on trial, so to speak, in the M conference for Jodi O'Brien. Chloe returns.
As Edina and Patsy prepare to attend an underground rave on New Year's Eve, they receive an unexpected visit from Patsy's long-lost older sister Jackie. Patsy insists on taking Jackie along to the party, much to Edina's dismay. However, Patsy is disappointed to learn that Jackie is no longer the jet-setting, drug-addled party animal she used to be. Now homeless, Jackie asks Patsy if she could stay with Edina until she can raise money to open a shelter for stray cats and dogs. After helping Jackie loot Edina's bedroom for valuables she can sell to raise money, Patsy throws her out of the house, but it is too late to go the party a frustrated Edina has fallen asleep in the sitting room, surrounded by her family as the clock strikes midnight.
An occult group is under investigation after one of their followers is murdered.
The Sliders arrive on a world that will be destroyed by an asteroid before they are due to slide. Arturo works with Bennish to develop an atom bomb to destroy the asteroid and Rembrandt gets caught up in an end of the world celebration, while Quinn and Wade confront their feelings for one another.
Luther risks losing agent Art Hibke by making a self-arranged promotional appearance without telling Art -- and then refusing to pay his commission, which leads to a crazed dental drilling; Dauber tries a new image.
Ray is unhappy that David has come to Portland. David panics when he discovers that his mother was fired, no longer lives at her last known address, and hasn't cashed her alimony checks for months. He turns to Donna for help, and Ray behaves like a total jerk. David and Donna cannot find Sheila at any of her favorite hangouts and learn that she was recently arrested. Donna misses Ray's concert; he explodes and shoves her against a wall in their hotel room. He later feels guilty and loans David his truck. Mel flies in from Los Angeles and tells David that Sheila has a long history of mental illness. They receive a tip that she is living on the streets and take her to the hospital. David realizes that Donna is happy with Ray and decides to back off. Dylan explores hypnotherapy in the hopes of understanding the main character in Charley's script. Valerie gets a tattoo. Music: ""Fever"" by Peggy Lee (#8, 1958); ""Why"" and ""The Comfort of Strangers,"" performed by Jamie Walters
The investigation into a double murder leads to a young alcoholic whose family once lived in the victims' house and who had admitted to his AA group that he's had nightmares about killings.