John F. Kennedy’s doctor administers him meth for his back pain, and Dr. John C. Lilly takes LSD while studying the intelligence of dolphins.
Ms. Snap helps Ms. Watson find her inner floozy while simultaneously getting into a relationship of her own. Mrs. Adler and Toby try to teach their students about the effects of bullying.
Jazz's boyfriend, Ahmir, visits; while Jazz learns to kiss and falls for Ahmir more and more, her friends have major concerns; Dr. Bowers asks the Jennings to fly to NYC so Jazz can be examined ASAP; Jazz goes missing and her parents fear the worst.
The Ross crew uprights a wreck filled with loose car engines, prompting a dangerous offload; a sudden stop shears off a truck's cab, shutting down the road to the border; John Allen heads down a steep ravine for a delicate recovery.
Junior is working at Stevens & Lido as an intern and takes some time to find his footing; but when he offers an idea during a pitch meeting, Dre immediately puts him in his place. Meanwhile, Bow has a meeting with one of Kyra’s teachers and learns that she has an aptitude for chemistry, but Kyra doesn’t want to transfer to a magnet school.
Beth's trip home to care for her mother sparks an unexpected realization.
Against Murtaugh's advice, Cole reaches out to Tom Barnes to help with a case that hits close to home, putting Murtaugh and Cole's partnership to the test. Meanwhile, Trish prepares to announce her campaign for District Attorney.
Things get out of hand fast when Hampton DeVille starts tracking when people leave their desks.
A horrifying discovery at the Hayes house changes the course of the investigation. Perez establishes the probable cause for Daniel's murder and his sister Zezi's disappearance.
After a Scoutmaster vanishes when he and his troop witness a strange craft hovering in the woods, Hynek is sent to investigate for Project Blue Book, while Quinn is pulled into a rogue mission for General Harding.
Appa and Umma find new ways to spice up their love life, while Janet learns more about her parents than she bargained for. Kimchee tries to prepare for his first corporate presentation while Jung can't help helping.
Lauren can't access her powers when it matters most, leaving Caitlin to take matters into her own hands when they are being pursued. Reeva finally reveals her plan for the Inner Circle and it's darker than anyone could have imagined. Meanwhile, Jace confronts some regrets about his actions and is torn between pressures from the Purifiers and his own beliefs.
Johnny suspects that Ted’s mom is attracted to him, while Moira can’t resist getting involved in a local musical production.
Pride and the team reunite with conspiracy journalist Oliver Crane after the source for his latest vigilante story is murdered. Also, Hannah’s former partner, Liam Somers, surprises her in New Orleans and shares a shocking revelation about an old case.
The kids promise to help Dad with the grand opening of his new restaurant by coming up with promotions. But their lack of teamwork and crazy promos lead to an ultimate nightmare in the kitchen for Dad.
Shaun’s blunt honesty with a distraught mother of a critically ill newborn baby causes the new chief of Surgery to question keeping him on as a resident.
Bull gets to work alongside his idol, Walter Franklin, a legendary lawyer who asks him to help a family bring suit against the U.S. government for the wrong death of a man killed while in witness protection. As the trial gets underway, Bull’s admiration for Walter is tested when the eminent litigator begins to deviate from Bull’s advice in court.
Michaela, Ben, Zeke and Saanvi all have the same calling. After another panic attack, Saanvi is finally ready to see a therapist, but it may not be what's best for her. An ominous new link appears between Griffin and the 828 passengers.
Bell's confidence in Quovadis continues to waver when the poster child for one of its medical devices, Henry Barnett, is rushed back into the ER, experiencing seizure-like symptoms. Meanwhile, Mina's past comes to light when her mother, famous Nigerian surgeon Dr. Okeke, pays a visit to Chastain, and Conrad makes a risky move when Henry returns to the hospital.