Following a stunning betrayal to their team, Brian and the FBI race to stop an NZT-enabled Sands and his associates from orchestrating an international incident. Also, Brian experiences devastating side effects when his NZT immunity starts to wear off.
When Jimmy has trouble admitting that he's , he throws himself a second th birthday party. The party triggers flashbacks of where he was a year ago, showing Jimmy what a difference his family has made in his life.
The reunion picks up with Yolanda taking some of her friends to task for questioning her health issues. Tears are shed and apologies are made. Old wounds are opened when Kyle's sister Kim Richards returns to talk about her difficult year that's been splashed through the tabloids. When Eileen confronts Lisa Vanderpump about not understanding her, Lisa breaks down in unexpected tears.
Jake Anderson tries a dangerous short cut with only one working engine on the boat. Casey and Josh perform surgery at sea. Edgar Hansen captains the ship while his son Eric works as greenhorn. Captain Keith turns his life around.
The murder investigation of a suburban mom takes a turn when her child is abducted.
A teen patient with abdominal pain firmly refuses any drugs. Meanwhile, Dr. Halstead reconnects with his past when treating a patient; a pregnant woman does everything in her power not to deliver the child; and Dr. Rhodes tries to avoid family issues.
Lex finds out that a woman who had close contact with an infected patient has disappeared.
Maxi puts his life on the line to rescue two fishermen from a capsized boat. Meanwhile, Jethro is furious after rescuing a group of tourists who have ignored several warnings about going into a rip.
A possible sighting of Genghis Khan's lost tomb dead patches in the desert and the world's oldest and strangest lakes.
Jenna tries to decide between success at Idea Bin and her tenuous friendship with Matty. Jake has an unexpected hookup, and Sadie and Sergio find themselves baring more than ever before.
The team reels from their losses as Hive continues to draw Inhumans to his side Agents Fitz and Simmons get a lead that could stop the maniacal Inhuman forever.
When a Chinese pop diva is killed, her female bodyguard is blamed for the murder, who appears to have been passed out at the time of the homicide.
Claudia comes up with alternative ways to make money when the jade business is slow. Joshua is burning out after many days driving on rough trails.
Claudia and Robin Bunce own a large jade mining chain and tourist shop in remote Jade City, Canada. If they strike it rich, everyone wins - if they fail, whole town suffers.
As the hunt for the abducted couple continues, a hunch leads Karl to another body. Plus, a man steps forward with intriguing links to their missing man.
After being emasculated in front of Cece, Schmidt insists on a manly bachelor party weekend in Vegas, but the road trip goes awry when the guys end up at a desert biker bar and he must put his newfound bravado to the test.
Alison brokers a peace with Paul in time for the gastropub opening, but Joe goes missing.
When a school shooting breaks out during the investigation of a tattoo, the team splits up to take down the shooter. Mayfair copes with some issues from her past.