While visiting a pharmaceutical lab on a murder case, Abby is trapped with no communication to the outside world after armed men take over the building and hold everyone hostage.
When Barry and the team find out Captain Cold has been kidnapped, they form an uneasy alliance with his sister, Lisa. However, Barry feels double-crossed when he finds out Snart is working with his father, Lewis Snart on a heist. Meanwhile, Joe is faced with a difficult decision.
Liv eats the brains of a recently murdered trophy wife who was pushed to her death from the balcony of her stunning architectural home in the hills by a hired hit man. A Pinot Grigio-sipping, suddenly fashion obsessed Liv and Detective Babineaux begin questioning suspects in their search for the original brains behind this murder. Meanwhile, Liv and Ravi are surprised to learn that Peyton has returned to Seattle.
Santanico confronts Malvado with Seth's help Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.
While Camille preps for her annual Halloween bash, the Stitchers team investigates the suicide of a young man, who may have abducted a missing college student. The stitch leaves Kirsten spooked, and she begins to worry shes being haunted by him as they race to find the missing girl.
A brandy-soaked wake up call cat dancing a life-or-death secret recipe.
Special Agent Pride is sent a partner from the Australian Defence Force Investigation Service, Special Agent Naomi Parsons, after an Royal Australian Navy Lieutenant, who was key to international negotiations on nuclear weapons, is murdered in New Orleans.
The streets of Hell's Kitchen run red with the blood of the Irish Mafia, as the west side war comes to a head. Muldoon treats Christine to a night on the town, and makes a decision. Duffy gets surprising news from Deirdre. As Bullman's feelings for Fortune intensify, he's forced to make a decision about their relationship.
Al and Gord work to rescue a loaded semi that's teetering on the edge of a 300-foot drop. Colin faces a white-knuckle drive on a remote Alberta back road, and Jamie tests out a new driver, who might be in over his head.
Boden's job is on the line pending an internal investigation. Severide adjusts to Patterson, his new commanding officer. Dawson shakes things up at the work. Casey searches for important evidence in his investigation of Nesbitt. Herrmann tries to keep the peace with Molly's new neighbors.
Guest announcer Reba plus singer OMI, and actors Jesse Tyler Ferguson and Jane Krakowski.
Karl tries to prove to Natalie he can be more dynamic, but his tough-guy experiment backfires when a desperate jobseeker takes Trish hostage.
When a new couple, Lyle and Vanessa Gerhart, comes into their life, Stewart and Deb deal with The Dean Effect - people liking you only because you have a famous brother. Meanwhile, Dean finds himself in a similar situation with Claire, the first person he's ever met who isn't affected by his celebrity
After Jimmy misses Edie's second birthday party, he decides to throw her a big bash at his restaurant to make it up to the family. When Sara's brother shows up, he brings the party to a screeching halt by confronting Jimmy about leaving Sara to raise Gerald on her own.
Having reluctantly agreed to share information with Rosalind and the ATCU, Coulson and the team go in search for the Inhuman who is killing off other Inhumans, and May feels that Hunters mission to take down Ward is getting too personal.
Mary Jane is stuck in the house with nothing to do Cedric reveals his plans and SNC hires a hot replacement for Mary Jane.
Dave suggests revamping the calendar and considers the upshot of buying Twitter followers.
When Mary Jane is rushed to the hospital following her accident, the family will rally around her. In defense of their daughter, Paul Sr. will handle David, and Helen will unburden them of Lisa. Meanwhile, Kara fights for Mary Jane at SNC, as Shohreh and Greg will go to great lengths to edge Mary Jane out....