On the eve of their 20th anniversary, RJ's parents invite him to dueling dinners, and RJ is forced to choose between his mom and his dad. Meanwhile, Miles joins the cheerleading squad to lose weight.
Following a murder that appears to be a hate crime, Teresa risks tipping Gibbons off to her big-picture plan by boldly taking on the Chicago Police Department's corrupt "meritorious" promotion system. Meanwhile, Jarek is forced to face his own reality when Vonda receives an anonymous package that reveals more about the Wysocki family
Kaylie finally returns to training at The Rock, but the public is under the impression that her time away from the gym was from an ACL injury, not rehab for anorexia. Soon after, Sasha announces that Kelly Parker is going to replace Emily on the World team, and that Kaylie will be replaced, as well, since she has not had enough time to train.
Senior visits Mikey's gallery and is affected by paintings depicting their strained relationship. While both shops work on respective builds, Junior learns he has won his appeal of Senior's lawsuit, and Senior decides to make Junior a settlement offer.
When Balagan’s oldest friend, the larger than life Russian cosmonaut Oleg Olesky, comes to the Huxley, he brings more than the party. About to pilot the first private space tourism rocket ship, Oleg is there with Chase Galactic as they announce their maiden launch. When the head engineer, Randall, falls from the roof of the hotel, Oleg is the prime suspect. With his only alibi being the fact he was with his boss’s wife, which she denies, Oleg pleads for Balagan’s help. Balagan eventually figures out the true motive for Randall’s murder – and the real murderer.
Rob gives his mom, Patty, the full Hollywood superstar treatment when he casts her in an absurd commercial for a new credit card company he has invested in. Rob's cousin, Big Cat, loses a bet and is forced to appear in the commercial dressed as a "man-cat / ginger-lion", inspiring Rob and the crew to don red wigs and explore their "inner-gingers" for a day. At the red carpet premier of her commercial, Rob surprises Patty with an incredible special guest.
Victoria panics as her 30th birthday approaches, and drags Mike and Molly into her "life crisis".
Grace and Adrian shop for a wedding dress, and Amy is cornered into planning a baby shower for Adrian. Grace and Grant have relationship problems.
When Tiffany decides to leave New York because of her divorce, it means Connie must find a new job and Larry finally has a chance with his dream girl; however, they soon each get more than they bargained for.
The Daily News staff are stunned by the death of a colleague and it quickly becomes clear to Paddy that she is out of her depth. Assisted by handsome journalist, Terry, Paddy closes in on her prime suspect but without concrete proof no one will believe her so she plants evidence on him and informs the police. Suddenly realising she may have implicated the wrong man she confides in the one person at the newspaper she truly trusts, the once brilliant Dr Pete, a journalist of some repute now dying of cancer caused by a lifetime’s hard drinking. But her realisation comes too late.
When pre-med freshman Beth Garrett is found strangled to death, a mysterious text leads the detectives to a potential suspect. After some investigating at her sorority, the detectives learn that there is more to this mild mannered bookworm than initially meets the eye. Meanwhile, DDA's Dekker and Rubirosa are forced to change their strategy when game-changing evidence is discovered at the last minute.
As the gang prepares for prom, Dixon and Annie learn some troubling news about their futures, and Ivy discovers that Raj's health has taken a turn for the worse. With Silver away in the hospital, Adrianna tries to rekindle her romance with Navid. Meanwhile, Naomi and Max's relationship is strained to the breaking point.
Charlie is finally starting to feel less like a fish-out-of-water with Serena and her friends, but complications present themselves when Charlie is invited to attend the Constance Billard alumni fundraiser. On the road to "happily ever after" Blair finds herself torn between the men in her life. Jack Bass return to the Upper East Side sets off a chain of events that could end up destroying Chuck and those closest to him.
After reluctantly going to Irina's, XIII and Irina are captured by a rogue team, and after escaping they are hunted by the commandos. Meanwhile Jones and Amos are becoming suspicious of CIA Director Frank Giordino.
Chuck and Sarah’s wedding prep includes one final detail: ensuring that the mother-of-the-groom makes it to the ceremony alive. Meanwhile, Morgan’s responsibilities as Best Man include his most dangerous mission yet, as he faces Vivian Volkoff. Elsewhere, Ellie tends to the last details of the rehearsal dinner and seeks help from an unlikely source.
XIII and Jones travel to Chicago in search of an agent who has one of the watches.
With the invaluable information that was shared by Agent Jenna Kaye, Five-0 is closer than ever to capturing Wo Fat. Their mission takes an abrupt turn, however, when Danny is exposed to a lethal neurological agent that presents an even greater threat: bio-terrorism on the island.
After losing a bet with Wilson over a boxing match, House is convinced that his fighter has an underlying medical condition that cost him the fight. While he tries to prove it, he leaves his team alone to help a bomb scientist who suffered a seizure. Meanwhile, House may be experimenting with a new drug to help his leg pain.
This trip Guy's rolling coast to coast for flavor. In Astoria, New York, a dive bar cranking out slow roasted lamb ribs with fresh tzatziki. In Geyserville, California, a third-generation Italian restaurant serving up the family meatball recipe in a slider. And in Indianapolis, a catering kitchen turned restaurant where something called tomato bon bons have become a local favorite.