After getting a call from his brother Christian, Jake must help prove him innocent in a shady murder case. Meanwhile health issues creep up on Mal and Des along with Tinny take on a case by themselves.
The BAU team travels to San Francisco to investigate the murders of several homeless men and teams up with a separate group of BAU operatives who are working another case they think is connected.
Kyle "friended" the wrong person and now all of his old friends are deserting him. His situation is desperate. Kyle looks for help from the one person who has always been there for him.
A pharmaceutical company ignores FDA safety guidelines and patients pay the price. A would-be marketing mogul relies on investor trust and faith. Jeanetta Standefor convinces clients their cash is rescuing homeowners from foreclosure. But, while investors think they’re helping neighbors stay in their homes, Standefor is helping herself to millions! American Greed profiles a Flipping Frenzy Scam!
The chefs are tasked with using aphrodisiac ingredients while creating dinners that would be appropriate for a first date.
As Hilda's wedding approaches, Betty asks Daniel to be her guest, Amanda tries to set Marc up with soap opera star Spencer Cannon, Justin wonders whether he can invite Austin, Wilhelmina finds a way to get the Meade empire and Betty gets an unexpected offer in both her personal and professional lives.
Max gets a new behavioral aide that really works for him, while Drew gets beaten up by some jealous guy at the school. Meanwhile, Crosby is trying to tell his parents that he has a son.
Anna introduces her pilot program to invite select groups of humans to stay on each of the 29 space ships. Ryan must deal with the fact that Valerie's pregnancy is wildly accelerated. Tyler learns a secret about his mom and one of the team makes a sacrifice to save Ryan.
On the island, Widmore subjects Desmond to a large amount of electromagnetic energy as an experiment. In the flash sideways, Desmond, with the aid of Charlie, starts to have visions of his life in the original timeline.
Alicia and Will defend a college student accused of killing her sorority sister while under the influence of a sleep aid. At the same time, they also deal with their growing sexual tension and Diane and Kurt McVeigh continue their flirtation.
Raylan leaves to California to follow the trails of a criminal who has evaded him twice in the past, and Raylan is determined that the third time won't be the same.
Murdoch is invited to attend a mysterious meeting in High Park. With Ogden to accompany him they find themselves mixing with some of city's greatest minds at a meeting of the Toronto Society for The Advancement of Eugenics, lead by James Pendrick. Murdoch discovers that Sally Pendrick invited him. The guest speaker is none other than the great science fiction writer HG Wells, and beside him stands Ruby Ogden, Julia's younger sister.
John, Ben, and Chickie are sent out as part of a maximum deployment to capture the “Canyon Rapist,” a perp who's been impersonating a cop. Russell is back, but on light duty as he continues to struggle with his recovery after being shot. While working a double-homicide with his old partner, Lydia, he discovers he's no longer up for the job. Sal plans a special night out to commemorate his wife's promotion, but their evening is ruined when their daughter reveals Sal’s affair with TV news reporter Mia Sanchez. Chickie gets a chance to prove to herself -- and others -- that she still has what it takes to be a good cop.
Annie deals with the outcome of Jasper’s decision to jump from the Hollywood sign and begins to find some peace with her situation. Silver and Teddy decide to double date with Liam and Naomi, which makes Dixon and Ivy feel left out, so the two decide to fake date. Adrianna and her band perform for the first time at the Beach Club and, with her newfound confidence, Adrianna decides to make her relationship with Gia official in a very public way. Liam encourages Naomi to come forward with her sexual harassment case, which causes her to continue her lie.
In an attempt to build up some confidence, Ian joins the local boxing club and quickly strikes up a friendship with the owner, Jock. But when the club faces closure due to Jock's debt with Paddy, Ian enlists Maxine, Carl and Chesney to help raise funds. However, it soon becomes clear that Ian has stumbled into a hornet's nest of unfinished business between Paddy and Jock. Meanwhile, a moment of heroism prompts Mickey to apply for a job with the fire service, but during the assessment he is haunted by old doubts. Returning a failure, he feels wounded, but his handling of a life-threatening emergency proves that he deserves respect. At the Gallaghers', Libby's biological clock is in overdrive, and to Frank's utter horror she makes it clear she wants to have children of her own before it's too late. Elsewhere, Liam is targeted by bullies, while Karen sets up a Chatsworth's Got Talent night at The Jockey.
Harry loses his cool with 3 swimmers that he's forced to rescue just seconds after warning them not to swim in a dangerous area. However, calling them "imbeciles" and "idiots" puts him in hot water.
The death of a Navy officer leads Gibbs and the team into the world of high-priced call girls, relying on D.C. Madam Holly Snow to help them catch a killer.
With an illegal arms deal and a hunt for Somali terrorists hanging in the balance, Detectives Goren, Eames, Nichols and newcomer Stevens combine resources in an attempt to bring justice.