The C.S.I. crew try to figure out exactly how and why a passenger on a private space shuttle trip died in space after his body is found having plummeted out of the sky...
A beloved former major league baseball player is found dead after a goodwill trip to Cuba. The investigation, which includes running into Joe Torre, leads the detectives into New York's Cuban community to solve the murder. Meanwhile, Alexis' genealogy project forces Castle to consider the identity of his unknown father.
When a teenage girl dies of a heroin overdose. Devlin and Brooks must find out how and why she came to be a drug mule.
When Lux gets suspended from school, Cate does her best to convince Principal Dugan to give Lux a second chance, but, unfortunately, her efforts may have made the situation considerably worse for Lux. Meanwhile, Baze is insulted when he finds out that Cate and Ryan are hosting a radio station event at the bar across the street.
Just as the gang are about to close another successful deal, a cruel twist of fate reveals one of the marks to be an undercover police officer. It seems the team might be in a spot of bother. Mickey and the team are arrested and unceremoniously thrown in the slammer. Things look like they have gone from bad to worse when Nigel Chambers and the beautiful Jennifer Hughes from MI6 arrive to question Mickey. The pair has a proposition for him and, unfortunately for Mickey, these two don't play by the book.
Dorcas is fascinated by the wealthy recluse Mr Reppington. What is his true identity?
Bill pulls out all the stops to win Paley's support for the State Senate nomination, while Nicki continues as his campaign's 'secret weapon.' Meanwhile, Margene gets the cold shoulder; Marilyn pitches to represent the casino's interests in Washington; Frank picks a bad time to drop by the casino; and Bill absorbs a last-minute sucker punch from Coburn.
After moving into their new crib, the Aqua Teens re-unite with some old friends.
Newlyweds move in next door to a veteran married couple of 25 years.
George's relationship with Sam continues and Annie is left looking after a ghost baby.
It's Christmas Eve, and chaos reigns in the emergency room. Fitz contends with some hard-assed cops and a belligerent patient. It's a contentious situation that he initially handles well, but as the evening progresses he spirals out of control to a very self-destructive place. When Chen finds himself dealing with a family of a man who died in a brothel, he starts to question his own views on medicine and family. Meanwhile, though she's not embroiled in the turmoil of the hospital, Ming is confronted by her father's strange solution to her fertility problems.
Lupe falls in love with Fanboy after he "saves" her from a spider. Problems arise when she won't stop pestering Fanboy once love-struck.
Fanboy assembles a mop girlfriend as a date for his school dance. However, when Chum Chum's date, his cousin from West Apetown, arrives at the dance as well, Fanboy falls for her.
Dr. Doom conquers Chthon's mystical dimension to free his mother Coco Von Doom. Though Doom ends up with Chthon's evil powers, he also finds himself dealing with his mother's monstrous nagging.
Actor Ashton Kutcher hosts; Them Crooked Vultures perform "Mind Eraser, No Chaser" and "New Fang." Sketches include "On the Record w/ Greta Van Susteren," "Gertrude's Will," "The View," "Cialis for Threeways Commercial," "Roman Slave Boy," "Weekend Update" with guests Liam (a teenager who just woke up), Eliot Spitzer, Jean K. Jean, and Garth and Kat, "What Is Burn Notice?" "Access Hollywood's Oscar Coverage," "An Even-Tempered Apology from Rahm Emanuel," and "Wedding Band.
Duke is excited when his sister Stamps comes to visit, but is shocked when he realizes that Stamps is engaged to his arch-enemy, Baxter. However, the animals learn that Baxter is after Duke and Stamps' uncle's priceless dog bone collection. When they try to frame Baxter for chewing up a couch at his bachelor party (so that Stamps will dump him because she hates couch-chewers), Duke beats him to it and now scolded in front of Freddy and Peck. So at the altar, Duke tells Stamps about Baxter going after the dog bone collection, she dumps Baxter and he is launched in the field.
SpongeBob and the rest of the Bikini Bottomites travel to Texas to try to save Sandy from a rodeo.