An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagnosis before both die. Meanwhile, Cuddy adopts a newborn but when the birth mother displays a rash, she has to make a decision between putting the mother or daughter at risk.
When a girl is found covered in blood and holding the murder weapon that killed her best friend, she becomes an obvious suspect, though she can't remember anything. But Jane, believing she's innocent, engineers a risky maneuver in which she must relive the terrifying events in order to spark her memory.
Mike teams up with the boys from Bartos Bait & Fish to catch leeches that will later be sold for fish bait. Then it's off to the Green Tripe factory in Hollister, CA where Mike helps make BARF (Biologically Appropriate Raw Food) for dogs.
The team must shift their attention from a case they are working on and hand it over to Martin, after a child is reported to have been kidnapped at a mall.
Efficiency expert Emmett Milbarge pays the Buy More a visit to inspect the branch, while a global terrorist looks for Jeff. Chuck needs to socialize with Jeff to find out about his connection to the terrorist. Finally, it all comes down to video games and the prevention of World War III.
Jenny befriends a model, and is encouraged to explore her wild side. Serena is attracted to an artist, Aaron Rose.
Alan Shore and Denny Crane take a breather from the office and saddle up at a Dude Ranch in Utah. But the two city slickers soon find themselves at odds with their fellow horse enthusiasts and may need to call on the always irritating attorney Melvin Palmer - who also happens to be at the ranch. Meanwhile, Shirley Schmidt defends the murderous Catherine Piper Betty White when she unintentionally blows up her doctor after setting his office on fire for prescribing medication that almost killed her.
Harry's Roadhouse (Santa Fe, NM), Dor-Stop Restaurant (Pittsburgh, PA), Surrey's Cafe (New Orleans, LA) Guy Fieri checks out breakfast from east to southwest: In New Orleans, a juice bar makin' bagels from scratch; a New Mexico roadhouse mixin' Philly food with Southwestern favorites; and in Pittsburg, a family joint scratch-making pancakes with everything from peanut butter to pumpkin.
Lucas' novel receives interest from a suprising person, as does Mouth as he meets his new intern. Jamie begins to develop a crush on Sam and her rebellious ways, while someone becomes enamored with Brooke. Meanwhile, Haley and Nathan discuss his return to baskeball as his comeback begins to look more like a reality.
A man confesses to killing his polygamous wife but refuses to give details. Where's the body? What's the method or motive? Forensics is the key to bring this self-appointed "minister" to justice.
Dr. Adams asks Sam to participate in a clinical trial in an effort to regain her memories, but then the trial is "cancelled" just as Sam remembers probably one of the most important memories in her life.
Newlywed lawyers Mclean and Suzanne bought a fixer upper, but four years and two kids later, their house is still in need of upgrades.
Harry vows revenge by taking down the head of Russia's intelligence service in Britain with the help of Lucas North.
An Al Qaeda cell kidnap a soldier and demand that Remembrance Sunday be cancelled as it is an affront to all dead Muslim soldiers.
Martin explains that the Ancient Lights, the beings in the shooting star, have selected him as their chosen one to create a new world run by them. Using a radio broadcast he starts to control people all over the world by their star signs to make them compliant. Luke, however, does not have a star sign as he was created, rather than born, can withstand and eventually destroys Martin's control, freeing everybody. Rather than go back to his old life Martin opts to be transformed into a star while Sarah Jane declares the date to be Luke's birthday.
Always an attention seeker from childhood, fabricating imaginary illnesses, Grantham-born Beverly Allitt studies nursing, and, due to staff shortages, obtains a job in a local hospital, where she is well-regarded. Here she kills four children and attempts to injure another nine, for which she is put away in a secure hospital for life.
Tracy and Nathan try to save themselves from a dangerous Mohinder who wants to use their synthetic power laced DNA to find a way to remove Mayas/his own powers. Mohinder turns to the dangerous, power-stealing Arthur Petrelli to help Maya, and in return, Mr. Petrelli asks for Mohinder's help in developing the secret formula to give people powers. Meanwhile, Sylar is given the task by the comatose Angela to save Peter from Arthur at Pinehearst, where he was captured and rendered powerless by his him. Also, Daphne is ordered by Mr. Petrelli to kill Matt, but finds the ...