Paul begins to suspect that Susan is responsible for his rapidly declining health; Lynette and Tom butt heads over where to go on their family vacation, as well as which one of them will set it up; Gaby shows Juanita a horror movie and has to pay the price when her daughter becomes too scared to sleep in her own bed; and Bree runs into some trust issues when she goes out on a date with a detective.
The invasion by King Charles of France and Della Rovere proceeds with victory seemingly inevitable as the French sack the city of Lucca and the Italian powers flee to their banner, with Lucrezia's husband Giovanni Sforza poised to join them in the name of Milan; inventor Leonardo Da Vinci (guest star John Lynch) shows his drawings and blueprints for war machinery to the invaders.
Stewie and Brian go back in time to stop Bertram from killing Leonardo da Vinci in order to erase Stewie from the universe.
Bob and his family are forced to spend the weekend at Mort the Mortician's while the restaurant is being de-molded. Linda and Bob double date with Mort and a female mortician he meets online while Tina babysits Gene and Louise in Mort’s crematorium.
After Jeanie Long commits suicide, evidence comes to light exonerating her for the murder of teenager Abigail Mantel 11 years earlier. DCI Vera Stanhope and her team set out to retrospectively solve the killing, delving into the secrets and lies of a small community which still feels the repercussions of Abigail's death. Then the case takes an violent and unexpected turn - can Vera use her skill and instinct to find the truth and lay ghosts to rest?
To celebrate Christmas, the Browns head off to a snow-bound cabin in the mountains to get away from the pressure of their ongoing police investigation. And later, a decision will be revealed that will affect the families lives once again.
The Sister Wives struggle to accept that this will be their last Christmas in Utah; a massive change to the family dynamic.
Master Shake awakens to a surprise after a stint in a hyper-sleep chamber.
Even as small child, Nat was tormented by the feeling that he had been born in the wrong body.
A female wrestler capitalizes on a growing subculture that involves men who are sexually aroused by climbing into the ring and getting thrown around by muscular women.
Kissuiso is visited by a management consultant named Takako Kawajiri, wanting to revitalize the inn by having the mistresses wear new outfits. However, attempts to dress Ohana and Nako up in new outfits fares badly with the customers. After Takako takes her leave, Ohana's uncle, Enishi Shijima, feels downhearted that his efforts to help the inn are always rejected by Sui. As Ohana feels she should do something to help improve business, the janitor, Denroku Sukegawa, takes her to a secret room filled with old uniforms made by Sui over the years. Ohana and Nako decide to give these a try, which proves to be a hit with the customers.
Stan and Francine fight over how to redecorate the house. It goes so far that they split the house down the middle and try to live without each other. Meanwhile, Principal Lewis discovers a talent of Barry.
In the season finale, Horatio must capture an escapee again when their transport plane crashes. And the team was shocked to discover that the fugitive has planned more than that.
Mitch questions the validity of the police investigation while Richmond has to deal with a negative ad. It's discovered that Rosie was at Bennett's apartment the night she died.
Goren and Eames return to the Major Case Squad after a year-long absence and must determine if a banker was murdered or committed suicide. They discover the bank's only client is the Catholic Church and dig into a scandal and cover-up linked to the murder.
Margaret Bradley had Multiple Sclerosis and was living with her daughter, Rhonda, a nurse. A part-time aide helped Margaret while Rhonda was at work. In 2002, Margaret suddenly fell ill and died the next evening of unusual and dangerously low blood sugar levels. Rhonda, who knew her mother didn't have diabetes, looks into her mother's untimely end and wonders if her mother's death was really murder. Her search for answers would eventually lead authorities to open a criminal investigation.
Toni's investigation of a post-Katrina casualty gets more confusing at every turn; a routine closing at the bar for LaDonna becomes a disaster; Janette is forced to make a quick trip back to New Orleans to tend to a housing crisis; Nelson ups the ante in his business deal with Robinette; Antoine practices with his new band; Sonny turns to another musician for help when his home is vandalized.
Amy and Bob make up for not throwing Gabe his much delayed 12th birthday party by giving him a 12 ½ birthday party, after Gabe promised to be good for a whole week. Unfortunately, Gabe's party falls on the same day as a huge blizzard. Meanwhile, Ivy and Teddy cannot get along with Ivy not liking Teddy's new boyfriend Derek, which causes a rift in their friendship. They go to each other's houses to settle their differences, the same day as the snow storm. Teddy is driven crazy by Ivy's parents Mary Lou and Harry (Ellia English and William Allen Young) while Ivy is having a great time celebrating Gabe's 12-½ birthday. Meanwhile, PJ helps Bob lose a few pounds.