Michael tries to motivate the Scranton branch to lose weight as part of an interoffice competition. Jim is lost after Pam leaves for art school in New York, and Angela continues to see Dwight even though she is now engaged to Andy.
As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.
Alex is offended when Izzie talks about how great a man Alex is to Meredith. Derek is stabbed with the scalpel in the palm of his hand by Rose, while the Chief is stunned over Mercy West's increase in the number of patients, a deadly ice storm ravages Seattle.
When Joy cons Make-A-Wish to send a celebrity to her trailer, Earl remembers a wish he stole from a dying child and decides it's time to cross him off the list. When he returns to the kid's home, he finds that little Buddy has exceeded all of the doctors' expectations and is still alive. Buddy asks Earl to produce his movie and suddenly all of Camden County find themselves starring in a high-octane action film. Randy surprises everyone when his acting skills get rave reviews.
Earl and Randy decide it's time to make amends with their childhood neighbors, the Clarks. But when they discover more skeletons in the closet than they had expected, the brothers find themselves needing to sort out some family issues between their mom and dad. Meanwhile, Joy has duped one-eyed Willy out of his glass eye, and despite Darnell's efforts Willy may never "see" that eye again.
When Mrs. Beady tries to run for mayor, Otis decides to run for mayor against her to avoid Mrs. Beady from exposing them as talking animals. Their competition goes horribly out of control, however.
Belle has a professional crisis. During a disastrous threesome with Bambi and a flashy nightclub owner, Belle freezes. She just can't go through with it. Why? She meets up with Ben and spells it out - she is in love with Alex. How can she ever work again?
Betty must make a life-altering decision about what to do with her life. Meanwhile, Ignacio lands a job at a fast food restaurant while Wilhelmina forces Daniel to make changes in his life.
The club travels to Nevada to store arms with a brother club; when the Mayans pose a threat, Clay decides to "patch-over" the tribe, making them an official charter; Tara's ex, an ATF agent, investigates SAMCRO.
Picking up where the season 4 finale left off. The team is investigating the death of a woman named Lauren Santana whom is linked to the bank robbery. She is a friend of Flack's sister Samantha. Also Mac has escaped the robber but the bodies are still piling up. So the team must quickly find the bank robber before he is able to get away.
The pieces of a dismembered body are found lying in a purple pool of water, except the head is missing. The team finds that the body belongs to Jared Addison, a science fiction writer who had several mental problems. With Sweets' help, several suspects are hunted down, however the team has trouble finding enough evidence with the victim's head still missing.
The contestants are given the task of designing for each other, inspired by different genres of music. They have $150 and one day to complete the challenge.
This episode demonstrates the production processes for pencils, metal recycling, coffee.
When Kenny becomes Joy's new "girlfriend," Eddie feels left out and gets jealous of their girl-talk. In an attempt to feel included, Eddie crashes Joy's '70s-themed work party and sends Joy to the hospital in a disco mishap.
Josh is on the island of Java in search of a bat with a 12-foot wingspan (that's not a vigilante). Then the team heads to the Philippines to hunt down a huge, mysterious river creature.
Bitsy Mae speaks to the church; Peggy explains her reasons for taking Bitsy Mae in; Brother Boy is troubled in Dr. Eve's therapy; Sissy, Noleta and LaVonda search for a missing Latrelle.
When an SUV carrying members of the team explodes, the rest of the team fights to save them and catch the terrorists responsible for the bombing.
Mike and KITT must deliver a package -- a task that seems easy enough until they learn the package is a man with a code built into his DNA. The task becomes more difficult when a mysterious woman gets in their way.