The remaining five candidates must create a store display for the new Xbox 360 at Wal-Mart. Real life meets reel life for the winners when they jet off to the West Coast to meet film executive Jeffrey Katzenberg, who gives them an opportunity to participate in a voiceover session for the animated movie Over the Hedge.
Stewie convinces Brian to go on a road trip with him to San Francisco to search for a man Stewie believes is his real father.
Stewie finds out that his life in the future is miserable. So he decides to go back in time and change events for the better.
After losing at a swim competition, Stewie trys to eliminate his rival by blowing up a lifeguard tower. His plan backfires though, and Stewie has a near death experience that seems to change him.
When Homer hears that the Isotopes are on a winning streak, he takes the family to the game. The first baseman’s game is going bad, caused by his sexy singing wife Tabitha embarrassing him during the game’s national anthem. Buck Mitchell sees Marge and Homer’s kiss on the game’s Kiss-Cam and comes to them for marital advice. They start working with the couple and Buck’s baseball career turns around, but it and the Simpson marriage goes awry again when Buck catches Homer giving Tabitha a neck massage. While Marge and Homer try keeping their marriage together they also try to get Buck and Tabitha back together.
Flashbacks take us back to to moving-in day on Wisteria Lane for Bree, Lynette, Susan and Gabrielle and how Mary Alice brought them all together. Back in the present, Bree gets some frightening news. Susan moves into a trailer after her house was burnt down. Lynette and the kids are staying at a hotel. After seeing a report on the news, Gabrielle believes Carlos died. Paul begs Zach to get him a good lawyer via Noah.
As the investigation continues on the suicides in Arkansas, the team believes it is a chemical release by worms that is the cause. Owen is charged with criminal negligence for the death by overdose of a school girl.
Huff has become ill, both emotionally and physically, because of his relationship with Beth. Some of the things Teddy has told others about his relationship with Alyssa finally catches up with him. Russell fails to a keep an important promise that he made to Kelly. Meanwhile Ben's attempt to reach out to Izzy fails.
Phil takes out his revenge on Vito, while Tony grows frustrated with Anthony's lack of ambition or work ethic.
Flashbacks take us back to key moments in time for Bree, Lynette, Susan and Gabrielle and how they connect to the present. After hearing Betty's message on her cellphone, Bree realizes she needs to escape from the psychiatric hospital and help Danielle, who has run away with him. When he sees Mike buying an engagement ring, Karl buys Susan a house. Lynette learns the truth about Tom's secret trips, while Gabrielle discovers a shocking secret her husband has been keeping from her.
Both Bill and Barb get social recognition as Barb is selected as a finalist for a "Mother of the Year" award and Bill is asked to become a member of the Salt Lake City Leadership League. Meanwhile, the sister-wives draw up their wills, and Rhonda gets to know what life outside the compound is like for teenage girls when she hangs out with Sarah and Heather.
Lahey appears before the police board. Julian prepares a surprise for Ricky. Ray becomes Assistant Trailer Park Supervisor.
When the victim's credit card is suddenly used a year after his death, Lilly re-opens the 2005 case of a counselor at a teens' rehab center who was shot to death just two weeks before he was scheduled to testify in a murder case. During the probe, Lilly feels a strange connection to the victim, and her personal attachment may end up jeopardizing the case.
Piper & Leo, with help from Coop's ring, must travel back in time to change the events that lead to the deaths of Piper's sisters. Meanwhile, Billie uses her power of Projection to do the same thing; many familiar faces gather to help Piper in her time of need.
After running into Orel at church, Coach Stopframe asks if Orel would become Bible Buddies with his nephew Joe, who isn't settled into christianity yet. Despite Joe doing bad things for fun, Orel believes that it he should be a loyal friend and go along with it.
Vincent finds a strange book store and an even stranger old man, where he discovers more about his true nature. Re-l and Iggy catch up on the Centzon (the Rabbit, the flying ship that Vincent travels by).
Ned enlists Moze's help to win a ribbon in the science fair; Cookie attempts to impress Vanessa and her grandmother. Ned tries to study for a test, but he is constantly distracted; Moze gets injured and must wear a traction device, which makes nobody want to talk to her; Cookie tries to sneak out of study hall to meet Vanessa, but the teacher refuses to give him the bathroom pass early.
The plans of John Lumic to convert the world into Cybermen are now in full force. The Tenth Doctor, Rose, Mickey and the Preachers must find a way to stop him from enforcing his "ultimate upgrade."
Don investigates the murders of two young women found in their cars outside their homes. Their deaths were made to look like drug overdoses, but Don realizes a serial killer is responsible. Meanwhile, Charlie is having bizarre dreams about his parents. In one dream, his deceased mother appears and tells him he has a question to ask her, but he can't imagine what it could be.
Annabeth prosecutes two teenagers for the murder of a man they claim was an online sexual predator. However, the more she investigates the more the teenagers' story falls apart. And at home, she and Jack make plans to go on vacation, not knowing that their lives will soon change.