When Sam responds to a fatal stabbing at Crester's Textiles he's shocked to discover that it's the converted mill where he lives in 2006. Sam sets up a forensic investigation but Gene already has a hunch about the murderer. Sam believes he has to stop Gene from sending an innocent man down for life. But does he have more to learn about this world than he thinks?
High Stakes Poker action continues and Barry Greenstein starts to get involved! Daniel Negreanu, Doyle Brunson, and Ted Forrest join Greenstein for another High Stakes Poker cash game.
Jack returns to CTU and has an emotional reunion with Audrey, while Curtis tracks the Russians and the stolen nerve gas. Walt sends in a hit man to silence Jack. Chloe discovers that Spencer has his own agenda at CTU. Walt convinces Logan to have Martha institutionalized when she tells them of the attack on her.
Sheppard's team meets a civilization about to be destroyed by a super-volcano, and is trapped there when the Stargate is destroyed during the evacuation.
Ted finds a new woman at the wedding. They want to remember the evening so they don't exchange last names or numbers; but Ted takes a big fall when he tries to find out her name.
Charlie finds himself in a relationship that is not based on sex.
The Mala Noche strike again and it's up to the CSIs to bring them down once and for all. Also, MAJOR secrets are revealed about the characters and their love lives.
Now that Nolita has changed hands and Jack and Mimi are in charge, Nolita is nominated for an EPICURE Award. However, Jack soon realizes that Becky's restaurant is also nominated for the same award prompting a series of mistrust and hostility towards Jack for welcoming her back into his life. Seth finally discovers Jim's indiscretion and Ramon sees the Virgin Mary in a Prize Lobster.
Bartlet must deal with the possiblity of a nuclear explosion in California, Kate is keeping a careful watch on the election in Kazakhstan and China's response, Will is acting as the government's voice this week, and Josh is trying to keep his political version of Tourette's in check.
Shane opens her own styling business, and Bette loses her position as the sole provider for the family, forcing Tina to take up a job under Helena. Now back in L.A., Jenny introduces Moira to her surprised friends. Dana and Lara make plans to visit France while Alice still obsesses over Dana. Meanwhile, Kit is surprised by The Planet's new manager who wants to make some drastic changes to the place.
Logan and Barek investigate after a body is found in the ocean, having fallen from an airline wheelwell. They soon discover that she is just one in a long line of prostitutes to be beaten and murdered. Their investigation leads them to a nervous airline employee, but they just don't feel he has the courage or the violent nature to commit these crimes on his own. A family connection leads them to a second suspect, with a history of both being abused and being the abuser.
Jenny steals a music player while in disguise as "Ruby Rocket," and an angry crowd forces Jenny to battle her alter-ego.
August 1942. Foyle investigates the a mysterious disease affecting local farm animals and looks into the arrest of a pacifist accused of stabbing a war hero.
Starr goes goth, and Jude goes goth as well to impress her. Meanwhile, the rest of the gang visits the movie theatre during a power outage at the mall.
Jordan and Woody investigate the death of two soldiers. One was killed in Iraq, the other has been killed in Boston. Dr. Macy confronts his daughter over her choice in boyfriends and a possible addiction to drugs. Jordan discovers a secret J.D. is keeping.
After learning that God's greatest gift is life, Orel recruits his friend Doughy to help protect that gift. A library book, a graveyard full of dead townsfolk, and Orel's convictions spell trouble for the population of Moralton.
Dr. Ron informs Susan that she needs a splenectomy. Gabrielle and her arch-enemy Sister Mary Bernard finally face off in church. Also, Tom decides to apply for an empty position at Lynette's job, which leads to the arousal of past issues in their marriage. Lastly, Matthew and Danielle's relationship is found out by both their mothers, which leads to big repercussions later on for Bree and her past secret with Andrew last year.
Angel puts his own life at risk when an American is held hostage. Meanwhile, Sergio and Anna's relationship continues to grow, and Venessa tries to make up for her past.
Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively. George is given a hard task to expel a discharged and defiant woman from the hospital. Alex learns his fate after re-taking his medical exams. At the same time Izzie is trying to stop Alex from making stupid decisions when a patient that doesn't speak English is lied to by her coach. George, Cristina, and Alex compete in a hot dog eating competition.