After Stan and Roger have a rough day, they get into a fight that leads to a "Freaky Friday"-type switcheroo where they get a taste of life in each other's shoes. But after the excitement of a new life stales, they face each other's problems as Roger is under pressure at work and Stan yearns to be needed. The swap gets out of hand as the family starts to crumble.
Gabrielle kisses Tom and Lynette is not happy and drives a wedge in her friendship with Gabrielle. Paul attacks Mike. The housewives become more suspicious of Betty and her family. Andrew is trying to blackmail Bree, but Bree gets some assistance from Susan's ex, Karl.
The squad is assigned to protect workers installing a pipeline. Meanwhile, Mrs. B is AWOL in Hollywood mixing with some questionable characters and Bo tries to run on his prosthetic leg.
Mail from forty years earlier is discovered, and a letter from Homer Simpson's mother's old boyfriend states that he is Homer's true father. Homer sets out to find his supposed new father, leaving Abe behind.
All eyes are looking forward to the Leo McGarry/Ray Sullivan Vice Presidential debate. Meawhile, Santos is trying not to catch his children's cold and he visits his home in Texas and continues to campaign. Jorge Santos, the Congressman's brother, may cause some problems at a gathering.
Bette and Tina deal with parenting Angelica while attempting to rekindle their relationship and handle an obnoxious social worker. Alice has a traffic accident, Helena gets into the movie business, Carmen and Shane's relationship gets more serious as Carmen takes her to meet the parents, and Jenny, recovering at her parents', has had enough with the Midwest and ponders moving back to L.A. with her new girlfriend Moira.
Four close high school friends each went their separate ways in 1980. Eight years later, in 1988, one of them was murdered. The homicide team receives a tip about the murder, prompting a re-investigation of the case and an examination of the friends' lives, hopes and dreams after high school.
After Joseph Sabo is found lying dead in the street, Barek and Logan investigate who was nearby that night that may have had a motive. They are soon led to Danielle Quinn, who had been blackmailing six different men claiming they fathered her child, asking for money. The detectives realise she was the one who killed Sabo, but when none of her victims will testify against her for fear of their wives finding out what they've done, Barek and Logan hit a dead end.
After Brian has a near-death experience in the hospital, he decides to lead a new life. He ends up getting a nightly singing gig with Frank Sinatra Jr., but his new lifestyle doesn't last very long. Meanwhile, Meg, after joining a new after-school group, pretends to be a lesbian.
Caitlin has paid up the credit debt she accrued a long time ago and is free to go, so she quits her job. Meanwhile doppelgängers of the gang show up in the mall because of the mischievous Trisha, Caitlin's ex-best friend.
Jordan and Woody are called to the scene of a murder at a bed and breakfast. It isn’t long before everyone is a suspect. When the road gets snowed in…things heat up between Jordan and Woody.
While Riley is busy convincing two reality shows that Granddad's blind and running a homeless shelter, Huey is being shadowed by a secret government agent. But is he real?
When her parents come for a visit, Billie accidently transforms them into assassins and also manages to contact a demon who is posing as a human. Meanwhile, Piper attempts to continue her life without Leo; Paige tries to make a connection with Henry; Phoebe tries to find a way to have her own life.
The final game has begun. While the Titans are spread out throughout the globe on one last mission, Brotherhood mastermind, the Brain, makes his move. Robin has a strategy of his own, but as all the villains begin taking down all the superheroes all at once, will it be enough to save his friends?
As the Ori plague spreads rapidly, SG-1 hopes that the Prior who caused the disease may hold the key to its cure. Gerak tries to rally the Jaffa to the Ori's cause, prompting Teal'c and Bra'tac to initiate a resistance.
The Battlestars Galactica and Pegasus face a new Cylon target, a "Resurrection" ship, while a power struggle threatens to result in all-out war among the human fleet.
When Don and his team are called to the scene of the murder of a Los Angeles gang member, they learn they are investigating the murder of another agent who had been working undercover.
Malcolm receives a check for $10,000. After Hal and Lois find out, they decide to keep the money and spend it on something for themselves. However, when Dewey overhears this, he wants to get in on it, too. Now, they'll have to find a way to pay Malcolm back.
Annabeth prosecutes a case involving a respected doctor who accuses a teenage delinquent of murdering his wife. Annabeth learns there's more to the story when the suspect arrested for the murder has an airtight alibi for the night the crime was committed. As a result, Annabeth delves deeper into the case only to find out that the doctor's wife was planning to sue her husband for divorce because he was hiding a dark secret.