A stand up comedian suddenly becomes a father when he takes custody of his sister's three children.
A free-spirited yoga instructor finds true love in a conservative lawyer and they get married on the first date. Though they are polar opposites, he fulfills her need of stability and she fulfills his need of optimism.
Mike Flaherty, the Deputy Mayor of New York City, and his team of half-wits must constantly save the Mayor from embarrassment and the media. Mike is later succeeded by Charlie Crawford.
A young girl, fresh out of high school, follows her high school crush to college to be near him.
Short-story writer Andy makes his living by working at a huge faceless company in present-day Chicago, writing technical manuals.
Inside the lives of staffers in the West Wing of the White House.
A black man is fatally shot by a white cabbie — who claims self-defense — and Clark defends Ortiz against the advances of a sleazy cop, Laughlin, who then challenges Clark to a boxing match. Meanwhile, Rodriguez fears he's being set up for dismissal on bribery charges, a gay man is killed outside a bar, and PAA John and his father make peace with each other.
Nick runs into an important person in both his and his father's lives, which may have a significant impact on both their futures. A woman asks for Nick's help, as a trust was set up for her young daughter who disappeared about 7 years ago, and she needs the trust money to save her home. Nick asks the detective who was on the case, and things get complicated from there. And Alvin and Laurie Solt, the social services worker, discover a mutual passion for helping juveniles who fall through the cracks when they need psychiatric evaluation and not just detention.
It's Prank Day according to Kelso, who manages to trick his friends twice with his stunts. The guys' attempt to retaliate backfires horribly when Red triggers their prank instead. But rather than venting his wrath on Eric, Red joins the prank war to show the boys how it's done. Meanwhile, Jackie throws an impromptu slumber party to cheer Donna up on her parents' wedding anniversary.
Jack and Mason use Palmer's campaign staffer Elizabeth Nash in a sting against Alexis Drazen which backfires badly on them. Kim makes a run for Rick's house after getting separated from Teri following the attack.
In a routine sweep to nab every outstanding suspect, the detectives divvy up the warrants. But when they cast their nets, they bring up far bigger fish than expected. Danny and Julien uncover a gun-smuggling operation and Mackey and his team encounter a pro-basketball star who's in town to play the Lakers, when they bust in on drug dealers. Meanwhile, Claudette and Dutch try to catch a man who has been raping women in an attempt to procreate.
Stanley's nephew, Justin, has a behavioral problem and is sent to stay with Stanley to give his mother a break. He ends up having a crush on Nikki. Kim's cousin, Tiffany, shows up and causes a rift between Kim and Stevie.
Toni plans a flashy grand opening party for her new real-estate business; Joan and William's jobs are on the line because of an April Fools' Day joke.
Debra decides to run for school president but Ray isn't sure he can handle the twins by himself during all those meetings so he votes against her. She loses and finds out that he voted against her so they get into an argument but her mouth is quickly shut when she reveals that she denied knowing him because he was embarrassing her.
Doug's parents visit while Carrie's on a business trip and take over running the house, making Doug feel like a kid again. Also, Arthur tries to strike it rich by inventing a new type of screwdriver called the Arthur's head.
Hot-tempered journalist Maya got herself fired yet again. Unable to find a job anywhere else and facing eviction, she is forced to go work for Blush, her father's fashion magazine.
A teenager, who becomes a werewolf after being bitten by one on a camping trip, uses his new abilities to protect his hometown from other supernatural entities.