Toni is furious to discover that Todd failed to deliver a message from a remorseful Greg before the wedding. Claiming that she needs closure but actually hoping to rub her happiness in Greg's face, she insists that she needs to meet with him. Todd fears that Toni still has feelings for Greg and threatens to leave her if she sees him. Toni declares that Todd needs to trust her; she ignores his ultimatum and meets with Greg anyway. Meanwhile, Joan is devastated when William's nephew/son cries every time she holds him, as she sees it a a sign that she wouldn't be a good mother. After Jabari tells Maya and Lynn that his classmates think they are lesbians, Maya angers Lynn by saying that she wouldn't even be her type.
Tired of all the bounty hunters and robots failing, Aku fights Jack, mano y mano.
Jimmy injuring his back making out with Christine throws a wrench into Don's plans to take him on a father-son ice-fishing tournament.
Stitch has been recently very successful at capturing and repurposing the Experiments, but it's gone to his head. He thinks he's too good for everything and is being a royal pain. But things are set to change when Pleakley goes into Jumba's ship and sees an experiment pod with the number '627' on it. Jumba has been making a new experiment. Luckily, it's in containment. That is, until they leave the ship and it escapes! Now it's employed by Gantu and Stitch wants to prove he's better than it. But he just gets beaten, and as 627 can't be turned good, Lilo and Stitch are in trouble...
When Nikki becomes Professor Oglevee's teaching assistant, she butts heads with the pretty young student who flirts with him for special treatment. Meanwhile, Kim, Stevie, T, Regina and Freddy compete for $5,000 by volunteering for a psych study in which they are forced to live for three days in cramped quarters.
The day-to-day lives of three orphaned children who are adopted by aliens that have trouble adjusting to the local culture.
In jail after his escapade at Ellen's party, Geoffrey is visited by the ghost of his dead mentor Oliver, who cousels him on the danger of trying to ignore his past feelings for Ellen, the woman who once broke his heart. Meanwhile, Holly and Richard work on their merchandising scheme, which involves a Shakespeare themed village of retail stores. Geoffrey is finally forced to fire Darren as director, to the relief of the cast but the worry of the Board of Directors.
Staff critiques vex Jack, who demands honesty and gets it, especially from servile Finch; a role reversal with Nina makes Maya a partygoer.
Robert and Amy convince their families to spend Thanksgiving together. When the Barones arrive at the Pennsylvania home of Amy's parents, they find that their differing family traditions encourage lots of lively conversation.
Matt and Sarah begin their student rotation in the ER, but get off to a bad start by arriving late and angering Dr. Norton, the attending ER physician. Matt and Sarah's relationship is tested when Matt quickly demonstrates an aptitude for the work, but Sarah accuses him of trying to make himself look better than the other students, especially her. However, Matt ends up looking foolish when he can't figure out how to turn off the ringer on his cell phone and he gets stuck fielding calls from his family. Matt's day ends tragically, leaving him to question his destiny.
Alan Shore uses questionable, if not illegal, tactics in representing his clients — Ted Grayson, a mentally unstable man accused of murder, and Karen Evanson, a woman who claims her husband's suicide was induced by a prescription drug.
The FBI worries that an upcoming march could be the target of a possible terrorist attack. Sue tries to enlist Betty's help in trying to capture her husband. Jack and the gang find where the Bubonic Plague was stored and how Joseph maybe spreading it. As Betty learns more about her husband she understands that Sue was right about him.
Hilary Duff and her sister Haylie impersonate two members of the Shangri-Las, a '60s girl group, in an episode in which the Vietnam War gets in the way of JJ and Beth, and Meg and Drew (Sam Page), when they go on a ""double date"" to Harrisburg, where Roxanne's friend Lenny is playing with his band. Meanwhile, Uncle Pete's drinking is getting in the way of his relationship with Nancy (Alicia Coppola); Helen is concerned about Will's state of mind as he recovers from his operation; Sam's getting interested in Malcolm X; and Patty makes a friend.
The Wisdom Cube claims to hold all the known knowledge in the universe, but it seems he only possesses a knack for tiresome anecdotes. Frylock has his doubts if this is all for real.
Sam volunteers to go undercover to discover how rationed gasoline is being stolen from a fuel depot, and Andrew becomes a suspect in a murder case.
Space Ghost is angry about a variety of topics, and rants mightily to his guest, comedian Dennis Miller
Gob decides to lock himself in his father's prison for 24 hours to get back in with the alliance, and to spend quality time with his father. Michael takes Gob's girlfriend to an awards show, and Buster inadvertently flirts with his mother's rival.
After making over $3000 from his own museum featuring a $1000 bill, Bart takes the family to London (on the suggestion of Grampa), where Homer is arrested for treason after crashing into the Queen.