Asanti, the most popular cheerleader in Breanna's cheerleading squad shares good news with the other cheerleaders about her losing her virginity with her boyfriend Rodney. The entire squad is happy for her, but when the cheerleading squad discovers that Breanna and Spirit are still virgins their popularity is threatened. Giving into peer pressure Breanna and Spirit decide to lose their virginity quick. Meanwhile after a burglar almost rob's Duane's apartment he and Flex decide to patrol the building to catch the crook. Also Arnaz's mom, Cheryl is worried about Arnaz and his raging hormones so Flex decides to talk to Arnaz about the birds and the bees. The next night Breanna decides to have sex with Arnaz to lose her virginity and remain popular but she changes her mind when Arnaz reveals he's not a virgin! After a long talk with Flex she realizes that she made the right choice and decides to wait until she's all grown up to have sex.
When Ginger returns from Avalanche Art Academy and ignores everyone around her but Darren, will Macie and Dodie join forces with Mipsy and Miranda to get them to break up? Meanwhile, Noelle loses Carl in a card game to Polly Schuster, a younger kid who is obsessed with birds.
Jimmy, Sheen, Carl and Captain Betty set out on a mission to capture the lake monster that has haunted Lake Retroville for at least six months.
Cate is unprepared for the diverse reactions exhibited by Bridget and Kerry on their first day back to school since their father's death. Meanwhile, Jim tries his best to be helpful by making some questionable home improvements to the Hennessy home.
Jack and Hector both search for Kyle, while Chase finds himself out of action at CTU. Wayne and Palmer argue over the implications of Anne's past, while Ramon takes out one of his opponents in a surprise move. Tony leads an operation to get Kyle, but tragedy strikes when Salazar's man gets there first.
This episode demonstrates the production processes for yogurt, candles, neon signs and bookbindings, and shows how each is made.
Looking for some fun, Brooke and Peyton crash a college party, but things turn ugly when one of the guys in the dorm, Gabe drugs Peyton. After Brooke calls Lucas for help, the two bond over caring for a sleeping Peyton, prompting Lucas to look at Brooke in a new light. Meanwhile, Haley gives Nathan another chance and the two go on their first date.
LSP teams up with Victoria Little to form AIDS Relief Alliance, meanwhile Nick becomes a medical guardian to two kids who may AIDS. Lulu learns she is about to be a mom. Nick and Susan Powell meet Mr. Wheat who learns that one his kids needs a home because she is HIV positive. Nick asks Burton for his for mom's engagement ring to marry Lulu after she sees the ring Lulu wonders if Nick is moving things to fast. Nick leans his client is HIV positive after he wouldn't give a blood test. Nick learns Calvin may have given HIV to his client.
Rory tries to spice up her articles for the student newspaper. Luke admits to Lorelai that he is revisiting a past relationship.
In a race against Tyr to control the Route of Ages, the crew find themselves in another universe. To save them, Trance finally reveals who and what she really is.
Eric arranges for Peter and his dog to visit a drug rehab center to cheer up the patients. Peter bonds with Nick and helps him reconnect with his estranged son. Lucy finds out that Kevin has been secretly coaching the Glenoak Police Department husband-and-wife softball team and demands that she be allowed to play. Just before his first date with Paris, Chandler receives a letter from Roxanne telling him she still loves him. Martin confronts Cecilia about her lingering feelings for Simon, prompting Ceclia to call Simon to let him know she has a new boyfriend. She is also surprised when he admits that he is also dating someone and Ruthie is jealous of Cecilia and Annie's close relationship.
Mary gets Wayne Newton to help an unlucky couple. A grifter passes counterfeit chips to Delinda. Sam is kept busy by two regulars who bet on anything.
Ray and Debra get caught up in telling lies in order to cover up previous lies. When the lies snowball out of control, Marie picks up the scent and traces everything back to the initial lie.
Greg is less than thrilled with Kim's latest thoughtful birthday gift to him. Meanwhile, Jimmy plans to go to extremes to get even with an old flame who dumped him.
The Hula Girls have ditched Mertle for Lilo, and consequently, Lilo neglects Stitch to hang with them at the Kauai Medieval Festival. So, when Experiment #586 is activated, Stitch needs someone to capture it with. And who does he team up with? Mertle. Strangely, Stitch and Mertle are having fun trying to capture the metal eater, but this ends when it storms the Medieval Festival.
The Mutant X team embarks on a mission to locate and capture a powerful super-mutant who possesses god-like powers.
When Phil the mechanic (guest star J.K. Simmons) correctly ""diagnoses"" meningitis rather than flu in Andy's young patient, the town begins to believe he is a seer. Ephram confronts Madison about his feelings for her. Amy agrees to see Linda Abbott for help, but out of desperation, steals her pad to forge a prescription for anti depressants, forcing Harold to heed Phil's warning about his daughter's condition. Meanwhile, Edna learns the disturbing truth about why her daughter does not want to pursue a relationship with Dr. Brown.
A gas man is engulfed in invisible flames and dies during a qualifying race at the Grand Prix Americas.
Stunt #1: Water Sack Contestants would be handcuffed, zipped up in a clear body bag, and dropped in a tank of water. They would have to use the key attached their wrist to unlock one of the cuffs, unzip the bag, swim to the surface, and grab a flag. The four contestants to complete this stunt the fastest would advance to the next round. The others would be eliminated. Stunt #2: Beetle Roach & Worm Transfer In a head-to-head race, contestants would be hung upside-down over a box of millipedes, Madagascar hissing cockroaches, and night crawlers. They would have 90 seconds to use their mouths to put the millipedes in a container on the right side of the box and the roaches in a container on the left side of the box. The contestant to sort the most bugs in each race would advance to the finals. The loser of each race would be eliminated. Stunt #3: Spinning Ledge Contestants would have to navigate a spinning cross-shaped wall high in the air. They would have of the release a fl
Phyllis announces that she has been seeing someone for the past month. She reluctantly agrees to bring her boyfriend, Earl, to the apartment to meet the girls. Earl is handsome, sweet and romantic, and leaves everyone (including Big Dee Dee) sufficiently impressed. Dee Dee sees Earl at a restaurant with another woman, and learns that it is his wife. Mona and Dee Dee try to break the news to Phyllis, and are stunned to discover that she already knew that Earl is married. She believes that he is separated and about to get a divorce. Mona and Dee Dee try to convince her to stop seeing him. Meanwhile, Spencer discovers that being attached has suddenly made him virtually irresistible to other women.