Tired of all the bounty hunters and robots failing, Aku fights Jack, mano y mano.
Jimmy injuring his back making out with Christine throws a wrench into Don's plans to take him on a father-son ice-fishing tournament.
Stitch has been recently very successful at capturing and repurposing the Experiments, but it's gone to his head. He thinks he's too good for everything and is being a royal pain. But things are set to change when Pleakley goes into Jumba's ship and sees an experiment pod with the number '627' on it. Jumba has been making a new experiment. Luckily, it's in containment. That is, until they leave the ship and it escapes! Now it's employed by Gantu and Stitch wants to prove he's better than it. But he just gets beaten, and as 627 can't be turned good, Lilo and Stitch are in trouble...
Horrified to discover that Ephram and Madison are involved, Dr. Brown stops short of firing her, but Madison decides to quit leaving the Browns to a very unhappy holiday, especially when Delia discovers another troubling relationship - between her father and Linda Abbott. Stressed by Thanksgiving with his cantankerous mother-in-law (guest star Betty White), Dr. Abbott reacts badly when Amy brings Tommy (Paul Wasilewski) to Thanksgiving dinner. Finally pushed to the breaking point, Amy runs away from home.
A young woman is attacked by a shark and later dies, but it's discovered that she was shot first. The case becomes even more difficult for the CSIs when one of their coworkers becomes a leading suspect. The dead woman worked for a private-investigation agency that specializes in luring and entrapping married men suspected of infidelity.
Dee Dee's cousin Barbara comes to town for Big Dee Dee's baby shower, and stays with Mona because there is no room at Dee Dee's place. Mona is furious to learn from Barbara that Dee Dee shared things that Mona had told her in confidence about the effect her mother's bitterness has had on her feelings about marriage. Mona gives Dee Dee the silent treatment, but later has a talk with Phyllis about her fears. Big Dee Dee dreads the shower because she knows the guests will insist on touching her belly. Meanwhile, Spencer gets a makeover from Adam and some friends in the hopes of impressing Camille's social crowd.
When Flex falls for Sheila, an ambitious, sexy sports columnist, he is willing to do anything for her, including bribing Breanna to tutor her son Eric. But when Eric is caught stealing Flex's stories from his computer to give to his mother, Flex and Breanna team up to seek revenge.
Toni is furious to discover that Todd failed to deliver a message from a remorseful Greg before the wedding. Claiming that she needs closure but actually hoping to rub her happiness in Greg's face, she insists that she needs to meet with him. Todd fears that Toni still has feelings for Greg and threatens to leave her if she sees him. Toni declares that Todd needs to trust her; she ignores his ultimatum and meets with Greg anyway. Meanwhile, Joan is devastated when William's nephew/son cries every time she holds him, as she sees it a a sign that she wouldn't be a good mother. After Jabari tells Maya and Lynn that his classmates think they are lesbians, Maya angers Lynn by saying that she wouldn't even be her type.
Malcolm skips out on Thanksgiving to go to a party; Reese becomes abusive to Hal and Dewey as he attempts to prepare Thanksgiving dinner.
The bludgeoning of a rich family patriarch has the detectives investigating several suspects, each with their own motives: his estranged wife whom he was about to divorce, a male friend of hers who was a parolee, their childrens' nanny, the victim's brother in law who is a doctor, even the oldest son. Goren and Carver call the family of suspects together to sort it all out... in family court.
Rita Sue teaches a newcomer a few tricks of the trade. Balthus is nervous about Tommy Dolan's allegations. Lodz gets approval from Management to help Ben.
When Sydney is taken into custody by the NSC, Jack and Vaughn have no choice but to ally themselves with Sloane to rescue her. But with only hours to spare before she is forced to undergo a radical surgery to recover her memories, they must put togther an extraction team, headed by freelance operative Brill (Richard Roundtree, "Shaft"). Meanwhile, Lauren faces an impossible choice -- side with the NSC, who she wants to believe is doing the right thing, or with her husband.
Realizing he's losing someone special, Charlie plans a Thanksgiving dinner to convince her he's a family guy and that she should be with him.
Bianca, a woman from the future, arrives to take Chris's powers, and Leo learns that she is actually part of an assassin family of witches. Meanwhile, Paige decides to move in with Richard, while Phoebe ponders joining Jason in Hong Kong.
Peggy overdoes it when she secretly slips Hank a testosterone supplement to combat his work-related stress. But he feels great, until he finds out.
Alan Shore uses questionable, if not illegal, tactics in representing his clients — Ted Grayson, a mentally unstable man accused of murder, and Karen Evanson, a woman who claims her husband's suicide was induced by a prescription drug.
The FBI worries that an upcoming march could be the target of a possible terrorist attack. Sue tries to enlist Betty's help in trying to capture her husband. Jack and the gang find where the Bubonic Plague was stored and how Joseph maybe spreading it. As Betty learns more about her husband she understands that Sue was right about him.
Hilary Duff and her sister Haylie impersonate two members of the Shangri-Las, a '60s girl group, in an episode in which the Vietnam War gets in the way of JJ and Beth, and Meg and Drew (Sam Page), when they go on a ""double date"" to Harrisburg, where Roxanne's friend Lenny is playing with his band. Meanwhile, Uncle Pete's drinking is getting in the way of his relationship with Nancy (Alicia Coppola); Helen is concerned about Will's state of mind as he recovers from his operation; Sam's getting interested in Malcolm X; and Patty makes a friend.