Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.
Vicki and Henry have a run in with Medusa, the gorgon of Greek lore. While looking for a missing male model.
Maria Spatafore requests help from Tony for Vito, Jr. Tony's bad luck puts a rift between he and Hesh. A.J. makes a major choice regarding his future.
Lois gets a job as the church organist, so the family decides to begin going back to church. When Stewie gets sick after receiving communion, the congregation becomes convinced that he has been possessed by the devil. While on the run, the family ends up in Texas, where Peter begins to fit right in with the cowboys, Stewie enters the "Little Miss Texas" pageant, and Chris and Meg sneak into George W. Bush's house.
Henry is shocked when he learns that his ally, Emperor Charles V of Spain, has released France's King Francis I from prison. He's equally surprised when Anne Boleyn turns him down after offering to make her his sole mistress.
Kimball tries arresting a magician performing without a permit, who cano get out of whatever restraint she places on him. Dangle accidentally releases a child killer free. A customer wants to file a complaint against the brothel for fraud. Junior and Jones deal with a drunk at a Renaissance Festival.
Mayko tries to get rid of the pain she's feeling in her phantom limb; the team investigates the high level of mercury contamination found in Lake McGraw.
The newly-created Dalek-human hybrid, and the other three members of the Cult of Skaro launch an attack on Hooverville, along with their Pig Slaves. The Doctor, Martha, and Frank manage to escape, but discover that the Daleks' plan involving the Empire State Building...
Drakken hires a familiar corporate consultant to start his next plans to take over the world. Meanwhile, Ron becomes obsessed in the actuary business.
The ancient organic weapon known as the Sun-Eater has been unleashed, and it lives up to its name. It heads toward Earth's sun and not even the Legion can stop it.
Bruce discovers that Wayne Industries is distributing alien technology across the world, and gains the aid of a mysterious new ally.
Now that Optimatus is free, he alongside General Deuce and Rupes Oberon plan to use Planet Blanc's wormhole generator to take over the universe. Planet Blanc is said to be at the center of the universe, and that every point in the universe can be instantly travled to with ease from it. The Royal Tweetums contacts the Loonatics for help. It turns out that Tweetums evaded capture. The Loonatics must find him before Optimatus does, but not without help from an old enemy.
Yeah, Kenichi’s a total wimp. He’s always getting picked on and doesn’t have a lot of friends to stick up for him. The guy needs motivation if he hopes to graduate in one piece. Well, Miu’s the perfect motivation. She’s hot, she accepts him, and she just so happens to live at a dojo with six martial arts masters. You could say fate has led Kenichi to their door, or you could say he was just following the hottie. Either way, he’s about to get whipped into serious shape. If he can survive some hard-core training, he might survive another day at school. He might even score with Miu. Yeah, you could call Kenichi a wimp. But let’s go with underdog instead.
Ragnarok's Loki and Siegfried capture Niijima and Kenichi goes for his rescue along Miu.
A teenage slacker is given the ability to turn into the American Dragon and defend all mythical creatures that secretly reside in the human world.
In order to avoid spending time with Sophie, Mark gets a gym membership. Whilst there he discovers that Jeremy's ex-wife Nancy is working there. Mark tells Jeremy who then becomes desperate to get back together with her. He decides to take a job as a cleaner at the gym and sets about stopping her from dating Mark's personal trainer Matt.
Derren teaches pensioner Anne to play poker and enters her into a professional tournament.
Green and Cassady get mixed up with the Russian consulate after Peter Rostov dies of ricin poisoning. Their investigation leads them first to his work, where they learn he spent a great deal of time traveling back and forth between Russia, and secondly to his brother, Karl. It isn't long before they link the Rostov brothers to an illegal prostitution ring trafficking in young Russian woman, but McCoy is faced with trying to get the remaining Rostov brother to testify so he can prosecute Brezin, the father of one of the trafficked girls.