Michael races against time and his ailing health to break into the Company headquarters to steal Scylla, but the break-in’s success lies with Sucre. Gretchen dresses up for a meeting with the General and one final attempt to get the last card key. T-Bag must make a decision to leave his criminal ways for good.
A baby is taken from her mother's arms in broad daylight, and the team must race against time to find her.
It's Thanksgiving time and Blair is offended when her Mom's new man hijacks her Thanksgiving traditions. Lily attempts to strengthen the frail bond between Rufus and Jenny. Eric discovers a secret about Bart. Vanessa and Chuck help Nate deal with his father.
Daisy protects Clarabelle's secret recipe for oatmeal raisin cookies from Pete.
A birthday party for one of Lily's co-workers leads to Robin connecting with a group of single partiers known as the "Woo Girls". Ted presents a plan for Goliath National Bank's new HQ.
Sarah finds that the strange dreams she's been having while she sleeps are slowly beginning to creep into her waking life, but she has no idea what the dreams mean for her and John. Derek and Jesse investigate a possible Skynet conspirator.
Lucas falls asleep and dreams of a 1940s Tree Hill were he owns Karen's Cafe. Here, Dan is a dangerous mobster and everyone is entangled in his web: Brooke owes him money, Mouth is searching for proof that would link him to Keith's murder, Haley is his former lounge singer, and Lucas is in love with his step-daughter Peyton.
When Karen forgets to pay for a muffin, she finds out what it's like to be on the wrong side of the law; Hank changes his email password, forcing Wanda to try to get inside his head in order to figure out what the new password is; Brent takes to the kitchen to prove that he can cook dinner as well as eat it.
The in-laws finally meet up, as Sam's parents meet Mel's folks for the first time.
It's Easter and the lack of happiness in Moralton leads several troubled souls to Forghetty's Pub for some unavailable solace.
Nathan learns of his father's plans, while Flint and Knox launch attacks on Hiro, Ando, Peter, and Claire. Meanwhile, Matt tries to revive Angela, Sylar meets with Elle, and Mohinder begins testing of his newest superpower formula.
A teenage boy accidentally stumbles upon a government conspiracy and is instantly absorbed into the world of MI5, ending up on the run. Lucas and the team battle to protect the boy from those who wish to silence him. Harry receives a cryptic message from his asset in Russia which could be the key to bringing down the high-level MI5 mole.
Heidi decides to go back to Brent and Sam and ask for her job back. Plus, Holly Montag's crashing at Lauren and Lo's since getting kicked out of her sister's place.
The gang launches a bloody bid to take over Rome's drug trade, but encounters stiff resistance from an intimidating underworld kingpin. Scialoja tries to get a new lead on the criminals' plans by tracking down Dandy's mistress Patrizia - only for his investigation to take an unexpected turn.
When Sarah Jane finds a time fissure, her curiosity leads her to go through it and she finds herself in 1951, in the village of Foxgrove, where she was born. Eager to see the parents she never knew, she makes a decision that will have catastrophic consequences
During shooting of a pivotal scene for "Smokejumpers," Vince gets contradictory direction from Verner, and Ari and Dana Gordon try to put out the flames. After receiving an unexpected call, Turtle has a clandestine meeting.
Hank tries to get the truth about Ashby; Karen confronts the record producer; Marcy detoxes at her mother's house; Charlie succumbs to temptation.
Susan's daughter Julie comes to visit with her surprising new boyfriend. Gabrielle learns that Mrs. Hildebrand has made her and Carlos heirs of her entire fortune. A reporter looks to expose Bree's imperfections. Lynette learns Porter and Anne Schilling plan to leave Fairview and disappear. Finally, everyone has gathered at a club to see the guys play in the annual "Battle of the Bands" when a fire erupts, threatening the lives of those in attendance. Some will fall as a hero will rise.