With his friends knowing how sour he acts when sick—and avoiding him as a result—Sheldon is nursed by Penny, who hasn't a clue what she's in for.
Jal has a secret so big, she can't tell anyone until she works out what to do about it. But as revision, music school auditions and needy best friends press down on her, the secret starts to leak out.
Hank has to resort to bribery to get Brent and Davis to see the latest hit movie with him. Oscar puts in a sidewalk in front of his house, and then forces Karen to guard it. Lacey joins the local women's club against her better judgment.
Jay and Manny have relationship problems. Emma, Manny, Liberty, and Ashley hit the road on a college trip and Jimmy and Spinner have also go on a road trip only to run into problems of their own.
Friends Scott and Justin travel through the more untouched parts of India, a quest which takes them to the highest mountains in the world. Into the depths of a storm, and ill from food poisoning, India challenges them both to their utmost limits.
Alan finds out some surprising information about Judith's sex life when he decides to go on a date with one of her friends.
Christine tries to control her hormones when her gynecologist says she may be entering perimenopause.
A shocking and brutal conclusion awaits Allison and Cynthia as they delve into the decade-old case of the kidnapping and murder of Cynthia's daughter. Meanwhile, Joe tries to get funding for a new invention and Bridgette predicts good fortunes for her dad.
Loyalty lines are questioned when Stephanie Pratt makes nice with Lauren at FIDM. Plus, Whitney travels to NYC to jump-start her career with People's Republic.
After their week in Paris, Lauren and Whitney are back home and have to adjust to the changes and the changes they plan to do.
When Drew decides to cut school to find Wayne Gretzky, Chris reluctantly agrees to go with him.
Zoey and James are finding it difficult to get some time alone. Zoey wants to go on a date with just James and none of their friends. Meanwhile, Logan and Quinn are tired of all of the sneaking around, and they plan a romantic dinner. Both couples, however, find their plans backfiring in unexpected ways as their night gets a little too crowded.
Kahn escapes to the bar and takes up Karaoke after Minh's father comes to visit. Meanwhile, Bobby and Peggy compete in an escalating game where they try to outdo each other.
Serena Williams guest stars. Tasha tries to take on Serena Williams as a client, Meanwhile, Malik schools Derwin on the type of women he should date. Also, Kelly sets Melanie up on a date with a celebrity.
After traces of blood linked back to a missing teen are found, the team re-investigates the 2006 case of a boy who disappeared from a high school for deaf children.
Three teenagers from the Pai Zhug Kung Fu Academy are chosen to fight the forces of an opposing academy and all other forces of evil.
With Lisa's encouragement, Marge pursues her dream of becoming a ballerina. But when Marge auditions at the ballet academy, Lisa is invited to enroll. Unfortunately, Lisa becomes addicted to secondhand smoke from the other dancers. Meanwhile, Homer's beef-jerky operation runs into a snag.