Howard is hell bent on a career as a serious writer in the hope that he'll improve his chances with Mrs Gideon. However, when famous publisher Hamilton Cork arrives at the Zoo-Niverse, he decides to publish Vince's literary efforts about a pink bubblegum character called Charlie. Meanwhile, Bob Fossil has embarked on a new breeding programme for the pandas.
Sean has just turned 40, and he is already noticing it. His body is aging, and he has developed "the yips", making his performance during surgeries decline. Julia breaks the news to Sean that her mother, Erica, is coming to visit. Erica tells them that she wants a facelift - and she wants Sean to do it. Sean would prefer that Christian do it instead. Meanwhile, Christian is having problems with picky Gina, who is trying to keep Christian away from baby Wilbur, because it isn't his baby. Having his own problems with age, he is rejected by a 25-year old at a bar. Christian decides to hire a nanny, who he ends up having sex with, and later learns that she is giving the baby drugs to keep it from crying. Christian tries to convince Sean to have botox, but he refuses (at first). They perform surgery on a woman who was shot in the face nine months earlier. She is brought along by her gay friend. The two are having problems because the woman loves Chad, but Chad doesn't love her in that way, because he's in love with his boyfriend. We learn that Chad and the woman were planning on shooting each other, but she couldn't pull the trigger, so Chad was left unharmed. During Erica's facelift, Sean panics and can't do it. Christian is having some trouble too - he's slept with Erica, the night of Sean and Julia's wedding. The surgery continues. Later that day, Christian is having problems with Wilbur, so he calls Julia to come help him. She gets upset on how Christian can't handle his own responsibilities, and snaps at him for sleeping with her mother.
Brian continues to deal with radiation treatment; Ben is tempted when a former student shows interest in him; Sam and Lindsay struggle with their mutual attraction.
Rob and Dr Hurley must put aside their differences to save the life of a baby during the process of birth. Meanwhile, Dr Whitman makes a pass at Polly, and Maria Orton faces a psychiatric assessment due to her allegations against Hurley.
George puts his stamp on the Fisher home. David cautions Nate about projecting his personal grief onto their clients; Keith applies for a glamorous new job; Joe challenges the logic of Brenda's 12-step plan; Claire reawakens her artistic muse after meeting a free spirit named Edie; and Federico proves that charity doesn't always begin at home.
Rebecca helps Johnny endure agonizing visions of his terrible car accident years earlier, which are triggered by his efforts to rescue a missing girl.
Ginger invites Darren to the BFF yearly tradition of going to the county fair, much to the dismay of Dodie, who in turn invites Courtney to annoy Ginger. Carl and Hoodsey tag along and end up freeing a "two headed" pony from the Nature's Oddities Tent.
Ed and Alphonse hope to learn more about the Philosopher's Stone when they lend a hand to a group of Ishbalan refugees being shipped further south.
City Confidential features real life stories in a wide variety of American cities. While many of these stories deal with murder, some also deal with attempted murder, and public officials caught in compromising situations, among other things. The cities featured vary widely in size, from the smallest village to the largest urban areas.
Billy, Mandy and Grim go to the beach where Grim falls asleep and Billy buries him in sand. When they leave, Billy only takes Grim's skull, leaving Grim's body to be found by a rich family that take it with them. With his adoptive family, Grim's body becomes a celebrity and refuses to go back with Billy and Mandy. Eventually, Grim's skeleton is reunited with his skull, but instants later it is shattered by dogs.
After spilling salt in a restaurant, and not throwing salt over his left shoulder, Billy starts having an unusual amount of extremely bad luck. The next day, Grim analyzes Billy and finds out he has a "Catastrophe Snail" attached to his brain, which is causing him the bad luck.
Savannah, the prettiest, most popular girl in school, who Angelica practically worships, decides to throw her party on the same day as Angelica's! Tommy and Chuckie, being amazed that somebody could actually out-mean Angelica, use Savannah's obsession with Senor Jumping Bean to ruin her plan!
When Monk travels to New York City to investigate his wife's murder, he gets tangled up in a baffling case involving the shooting of a foreign ambassador.
The Team attempts to crash the Annual We Hate The Kids Next Door Barbecue, only to find that the party has far more villains than they can handle! The team flees in their M.E.G.A.R.A.G.E aircraft, but Stickbeard and his band of buccaneers do not give up pursuit! When their craft is shot down by the Sweet Revenge, they land in the worst of places - in the middle of the ocean, in a disgusting sargasso of asparagus! Stranded, lost, with no edible food, a bad situation gets much worse when they are found by a great white aspargus monster! And when the vile vegetable seeks to make them its prey, all hope seems lost. Can their be any escape from this savage sprout?!
Noticing a change in little bro Danny since the accident in the lab, Jazz mistakes his ghost hunting for depression and signs him up for therapy with Penelope Spectra, not knowing that Spectra is a ghost who feeds off teen misery!
The battle continues on Cybertron as Optimus Prime and Rodimus once again act as one team. The Decepticons are able to cause more tears in the Energon grid, allowing Megatron to swoop down with the Terrorcons, bent on stealing the Energon from the core.
The Diffy's discover Curtis the Caveman stowed away in the time machine and now it's up to Lloyd to decide if they should keep him. Pim goes to Debbie's sleepover and tries to find a way out.
Phil skips Unification Day to go to a party that he can't even get in to. Pim cheats on a cooking assignent, so she has to bake something homemade.
Lloyd and Barbara decide to go on a weekend road trip for their anniversery. They leave Phil in charge of Pim and if everything goes right then Phil will get an afterburner for his skyak. Once Pim hears this she is not happy and tries everything in her power to make the weekend go bad so Phil won't get the afterburner.