After Russ Corbett and his wife are found in a seedy hotel room, Russ dead of an overdose, Eames and Goren follow the trail of evidence to Bernard Fremont, a professional partier. With his beautiful blonde companions, Fremont insinuates himself into the lives of couples who don't know the city very well, then robs them blind. While investigating Fremont's past in Asia, Goren realises that he is the mastermind that turned Nicole Wallace into a murderer, and his most successful pupil.
American troops arrive in Britain and the Corps of Engineers building an airstrip on a Hastings farm is met with resentment.
Nikki falls for the new salesman at Albatross & Finch named Hunter, so Nikki asks Caitlin to ask him out for her but Caitlin ends up dating him instead. Meanwhile, Jude and Wyatt start a psychic hotline because the real phone number is only a digit off Underground Video's number.
Jack and Chloe infiltrate Wayne Palmer's penthouse where David Palmer was assassinated, in the hopes of finding a clue to his murder. Jack convinces Wayne to cooperate and finds some information in Palmer's memoirs that leads him to the airport where the Russian president is about to land. CTU and Secret Service attempt to capture Jack, but they only find Chloe as Jack and Derek slip through their grasp. Martha tries to convince her husband that she received an important phone call from Palmer the night before his death, but a tape of their conversation seems to contradict her claims. Jack goes to the airport to find a lead, but a group of renegade Russian terrorists take hostages, including Derek, before he can act.
After a number of bad dates, Susan finally meets Dr. Right. Susan flirts with a handsome doctor, but they accidentally head butt. Meanwhile, some old pictures of Gabrielle turn up on the Internet. Tom is alarmed when his kids come down with chicken pox because he never had it. Bree gets arrested. Lastly, after months of silence, Noah Taylor contacts Mike Delfino.
The Russian and US Presidents are set to sign an anti-terror treaty when assassinations rock Los Angeles, a call from a distressed Chloe forces Jack into action and President Logan's wife believes there may be a conspiracy.
Cristina is bothered by a new year's mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. a heart transplant, 2. Izzie. Addison detests Derek's trailer, Derek visits Meredith's mom, George treats a young teen hermaphrodite frustrated by her pre-pubescence. Other news includes patients doing uncanny things and relationship havoc being wrecked between the doctors, as per usual.
The squad faces a moral dilemma when they discover millions of dollars. Mrs. B returns from being AWOL and finds a friend in Dim. Meanwhile, Bo is training hard to return to his squad and Vanessa is sticking with AA and trying to make amends.
Dr. Macy's job may be at risk due to a DUI charge, the night before he is supposed to testify as a witness in a high profile case. Jordan and Woody wonder where their relationship will go next...if anywhere?
Chase and Michael start an online show, The Chase & Michael Show. Zoey and Logan have their own segment on it called "He Says, She Says" and it all goes wrong when all the boys and girls begin fighting, so Dean Rivers cancels their show. Meanwhile, Nicole is depressed because she is failing Algebra because of cute boys, so Quinn and Lola try to fix her problem by using a hypnotis technique.
When Martin Luther King Jr. comes out of a coma after 32 years and finds himself thrust into the 21st and life in the post "September 11th" lunacy, his "turn the other cheek" philosophy quickly takes him from beloved national hero to dispised terrorist sympathizer.
With the intention of helping his parolee get a loan, Henry, along with Paige, go to a bank but instead the parolee decides to take everyone at the bank hostage. Meanwhile, Phoebe and Piper have their hands full when, during his third birthday party, Wyatt turns three of his toys into real people.
All seems lost for young heroes across the globe: they have been spread far and wide, their lines of communication have been severed, and one by one, the Brotherhood of Evil takes them down. But as The Brain claims his victory is assured, one brave hero manages to slip thorough the Brotherhood of Evil's grasp: Beast Boy.
Taking numbers instead of names, five extraordinary 10-year-olds form a covert team called the Kids Next Door with one dedicated mission: to free all children from the tyrannical rule of adults.
Classmates dare Ned to ask out Missy; Moze must wear a dress as part of a dare and meets three girls she suspects are robots; Cookie competes with Loomer to be the "King of Dares". Ned tries to fix his bad habit of saying yes to everyone; Moze tries to fix her habit of trash-talking; Cookie tries to replace his technology hoarding habit with something else.
Old Man Sedgwick's son is trying to put him into a home and Red intervenes to prevent it. Edgar Montrose tries to guess the word 'passion' in the Word Game. Red uses furnace ducts as car exhaust pipes. The fishermen discuss artificial intelligence. Bill and Winston try to cross the lake on stilts. Red makes a muffin gun. Also a handyman tip on cleaning the junk out of your yard without getting rid of it.
Technus is back, with a new plan to beam himself up to a super satellite and take over the world, and he's going to use Axion Labs to do it. As Danny Phantom battles Technus, Danny Fenton begins battling his feelings for Valerie, whose dad is back in charge at Axion. Sam and Tucker are surprised when Danny confesses he's thinking of asking Valerie to go steady. Unfortunately, as Technus puts his plan into action at Axion Labs, Valerie realizes her role as ghost hunter is putting her family and friends in danger. Can romance work between two kids with secret identities, or will the ghost boy and the ghost hunter end up breaking each others' hearts?