Lily and Marshall have their first Thanksgiving as a married couple; Barney is tortured by the slap bet countdown clock, worrying about when the slap will be dished out.
A serial killer is on the loose with a craving, making Calleigh its next victim, which also jeopardizes her ability to do her job.
Joan, William and Maya try to dispel Lynn's comment about them being old by going out to local clubs with her and trying to keep up with the younger crowd. Meanwhile, Lynn runs into Xander (guest star Quddus Philippe), who is still mad at her for canceling her performance at a rally raising awareness to save the environment.
George's room is getting very messy and George needs to clean it. The only problem is that when George crams everything into his closet, it just spills back out. Later on at the local supermarket, he sees the grocer's son practicing for a grocery bagging competition. He explains to George that a lot of stuff can fit into one small bag if it is put in just right, somewhat like putting together a puzzle. However, during another practice run, the grocer's son accidentally hurts his hand with one of the food items. He then enlists George to compete for him in the competition and must train him to bag properly.
Hundley is very itchy. It is the middle of flea season in the big city and the Doorman goes to give him a bath. After Hundley's collar winds up getting lost down a storm sewer, two women from the local animal shelter think he's homeless and take him away. George must find a way to break Hundley out of the animal shelter. He brings along Gnocchi, whose cuteness would make a great distraction and Charkie, who could probably figure out how to open the cage being the escape artist she is. George must also figure out a plan to sneak in, free Hundley, and sneak out.
Can Jennifer survive the visit from Fay and how will Jeff Audrey deal with no TV?
As a last ditch effort to try and regain some of her lost memory, Sam seeks professional help from a hypnotherapist, but doesn't get the help she expected. Sam hears a bombshell confession from Todd.
Heidi and Spencer constantly fight about how they should get married. Will they find a solution? Meanwhile Whitney has found a guy that asks her out on a date.
Maria (Yasmine Paige) and her dad, Alan (Joseph Millson), dig deeper into the mystery of Luke's (Tommy Knight) new parents and discover that Luke has actually been kidnapped by the Slitheen. There are more shocks when Sarah Jane (Elisabeth Sladen) and Maria find out that Mr Smith (Alexander Armstrong), Sarah Jane's super computer, is one of the bad guys. With Clyde (David Anthony) nowhere to be seen, Luke in the clutches of aliens and no Mr Smith to help, things are not looking good for Sarah Jane and Maria. But just what do the Slitheen want with Luke? And who, or what, exactly, is the Xylok?
Chris goes to work at a Chinese restaurant after Doc refuses to give him a raise. Drew is failing a class so Rochelle and Julius have to go in to meet the teacher.
After Hank falls in love with organic food he starts his own mini co-op garden in his back yard.
A young boy pretends to be God and performs surgeries on people to impress his dad.
In Libya, the boys visit Tobruk War Cemetery; Ewan is touched by the amount of people buried there from all over the world. It is an emotional day for the boys as they realize how much they miss their families back home. Arriving safely in Egypt the team are reunited again when David and Jimmy meet them at the border. Riding through Egypt there is still doubt as to whether they will make it to Aswan in time for the ferry. They are starting to feel the strain of the long days on the bikes, if they don't make it in time they will have to wait for a week before they can continue with the trip. This will delay them hugely and put pressure on their relationships. Ewan and Charley visit the pyramids in Cairo and are extremely lucky to have a private guided tour.
Peter starts an anti-immigration group after being caught up in the pro-American sentiment at a Veterans' Day parade, but his tune quickly changes when he finds out he was born in Mexico. Unable to prove his citizenship, pass the naturalization test or convince investigators that his marriage to Lois is for real, he ends up working as a groundskeeper on his father-in-law's estate and leading the fight for immigrant rights.
Zoey starts dating Dean Rivers' son. Meanwhile, Logan makes a dance video for girls so they can dance with him from the TV. Chase and Michael struggle to make 26 more cartoons for the end of the month, and end up getting sued by Friday Night Live for their idea of two bowling pins afraid of a bowling ball rolling towards them.
The town of Cranford is in a flurry at the arrival of a new handsome doctor. His controversial treatment of an unfortunate carpenter is risky not only for the patient, but also his reputation. Elsewhere a family suffers a loss but forges a friendship.
Dr. Roxo (The Rock 'n Roll Clown, He does Cocaine) is on the lamb and Toki decides to hide him at Mordhouse. The band decides to stage an intervention for Roxo.
Dexter is attacked by the man who murdered his mother. Meanwhile, Lila wants to get closer to Dex, and Debra and Lundy close in on the Bay Harbor Butcher.
Marge opens a gym for real women because she's disenchanted with Springfield's snooty, glitzy L.A. Body Works. Her gym, Shapes: A Gym for Women, is a huge success, launching a chain that makes Marge rich and famous. But Homer fears Marge will leave him for someone more attractive and goes to extreme lengths to try to save his marriage.