Lewis struggles to find a date to his ex-girlfriend's wedding. All of his friends (and even Mimi) try to help him out, but he inevitably drives all the women away with his creepy comments. Lewis becomes extremely depressed and refuses to get off of Drew's couch. Oswald brings in Lewis's mother, who reveals to Drew that Lewis has an IQ in the genius range. His family always kept the truth from him in the hopes that he could live a normal life. Lewis is thrilled by the news. He attends a Mensa meeting, but still strikes out with every woman. He begins to fear that he will never fit in, until a woman shows up at the meeting to deal with the building's rat problem. She has a high IQ and shares Lewis's love of bizarre trivia about serial killers, etc. They immediately establish a connection and set off to catch the rat together.
Sean and Eddie plan to honor their late cousin's wishes by scattering his Tupperware-borne ashes over the old water tower; Lily meets a cute guy at the funeral.
Jay gets a makeover after being compared to an old flame from high school. Meanwhile, Junior gets himself locked in a girl's locker after a misfortunate attempt to steal her bra.
Pacey's new boss proposes more professionalism in the workplace and promises to leave behind her attraction towards him, even offering Audrey her job back. Audrey suspects something is going on between them and refuses to return to Civilization. Later, Alex drops by at Pacey's and Audrey walks on them talking about their kiss. She storms out in anger, leaving the future of their relationship unknown while Pacey struggles with the growing attraction he feels for Alex. Meanwhile, Dawson runs into Amy Lloyd, the movie critic, and they end up in bed together. After sex, they talk about movies and she lends him her movie. Joey and Jack focus on studies, and while she has problems concentrating, he has to catch up an entire semester and even goes back to the fraternity house asking for help. Luckily, Eric (the same guy that caused Jack his expulsion) shows up at Grams with the needed notes.
The revelation that a Russian company may be building a heavy water reactor in Iran puts Jed in a difficult position as he prepares to meet with the new Russian president; Jed orders the Secret Service to protect C.J. when she receives death threats after making a comment at a press conference about the deaths of Saudi girls; Leo wants to find a way to help a major campaign contributor whose company is faced with a massive product recall; Charlie ponders the mystery of a strangely out of context letter written to the President.
Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.
The investigation into the death of a private investigator uncovers corruption, deceit, and immigration fraud in a Youth Baseball League whose manager will go to any lengths to win.
Lois gets jury duty and Hal tries to figure out what case she's working on. Meanwhile, Malcolm and Reese saw Stevie's mom naked and brag about it, they also take Dewey to the sewers and get lost.
Grissom and Sara investigate when a man's body, which has been doused with lye, is found buried in a park; Nick tries to determine how a hiker apparently drowned in a desert.
Dharma & Greg get stuck in a snowstorm after leaving the chalet and begin to wonder how their diverse upbringings will affect them as parents. (Part 2 of 2)
In the first part of this special one-hour season and series finale, Dharma and Greg find themselves once again trying to make peace between their polar opposite parents when an argument breaks out over whether the couple will vacation with the Finkelsteins or the Montgomerys. Dharma tries to appease both sides by arranging for everyone to spend the weekend at the Montgomerys' mountain chalet, but when the usual bickering and insults kick into high gear, it finally sends Dharma and Greg over the edge. Meanwhile, back at the office, Pete is left in charge of a routine SEC inspection, but when the agent turns out to be beautiful and female, he invents wild stories about inside trading... oh, just fast forward. (Part 1 of 2)
Charlie and Caitlin struggle to find security in their new relationship. To spite Charlie for downplaying an encounter with an ex, Caitlin accompanies one of New York's ten sexiest men on a business date to make Charlie jealous. Meanwhile, the Mayor plots a way to one-up his rival, the Mayor of Los Angeles.
Charlie and Caitlin are caught having sex on a surveillance camera in the Mayor's office and their secret affair is blown. Carter is finally granted a foster child, but is frustrated when he sees that Paul is better with the baby than he is - until the Mayor helps him tap into his paternal instincts.
Anya returns to Sunnydale, bent on vengeance on Xander for leaving her at the altar. She has reclaimed her vengeance demon abilities, but order to use them, she must get one of his frustratingly-forgiving friends to wish him harm.
Fez fantasizes about several musical numbers featuring himself and the rest of the gang while he gets ready for a school concert.
The cases of Harmon Rabb, former Navy fighter pilot, and his fellow lawyers of the U.S. Navy's Judge Advocate General's office.
Frasier returns to Boston to give a speech, and Niles, Daphne and Martin tag along to see the city. Once there, Frasier runs into Cliff Clavin.
The detectives investigate two crimes: the murder of a back-alley cosmetic surgeon and a violent rape; Clark finally takes Laughlin on in the boxing ring.
As Christmas approaches, Sharon goes on a shopping spree in New York while on tour with Ozzy and Jack. They learn that Michael, their security guard, has been arrested for robbing the house behind theirs. Michael denies any wrongdoing and insists that it was all a misunderstanding. He says he is filing a suit for wrongful arrest. The family, including Ozzy's eldest son Louis, gathers for the holidays. Christmas dinner features a number of arguments, but also several bright spots. Ozzy is very excited about the gravy he helped prepare. Jack receives a knife as a gift, but his parents want to take it away because they fear he will get into trouble with the law.