Cyclops heads solo to the desert town of Skull Mesa, where humans and mutants live in harmony, to visit an old mentor from his youth. But he not only finds himself powerless when he arrives, but discovers the place under the rule of a maniacal mutant, with none of the citizens willing to take a stand.
Sue insists the team get some R, but Johnny stays at home. The others head to Tee Vu island, which is home to a Kree Sentry. Meanwhile, Black Bolt destroys the negative barrier and frees the Inhumans, reuniting Johnny and Crystal.
Aisha faces a difficult decision in her Zeo Quest while the Alien Rangers battle Hydro Hog.
Adrian Toomes wants revenge when Norman Osborn attempts to take over his company, Toomes Aeronautical. He becomes the Vulture and immediately kidnaps Norman's son, Harry.
As he celebrates his first wedding anniversary, Norman Glass thinks he's the luckiest man alive. His wife Ady, whom he met after the tragic death of her first husband, is stunningly beautiful and talented. She loves him more than anyone alive. They have two great friends, Dennis and Barbara, who were arried on the same day and are just as madly in love as Norman and Ady. But suddenly things start to change. First, Dennis leaves Barbara. Then, Norman must struggle with the strange, growing revulsion he feels when he touches, smells, tastes or sees his lovely wife. Norman thinks he's going crazy, but Barbara and Ady know better. Is love blind? Is beauty only skin-deep? Guess again.
Russert and Munch are assigned to work a case together; they find a retired cop who was murdered near his wife's tombstone. The dead cop's son asks Lewis, whom he went to the academy with, to get involved with case. He also makes his own inquiries, which get him into a bit of trouble. A suspect is arrested; however, despite the overwhelming evidence against the accused, the jury acquits him. The son contemplates delivering his own justice.
Mark tries to end a rivalry with a coach from another high school basketball team.
A flirtatious girl disproves J.T.'s claim that a guy "would never trash a friendship over some stupid chick."
Dr. Sloan investigates a free health clinic after several homeless people turn up dead... with missing organs.
Mulder pursues Krycek (unaware of the alien that has taken over his body) to get back the DAT tape containing the MJ documents. Meanwhile, the shooting of A.D. Skinner uncovers evidence that could lead Scully to her sister's murderer.
At a recital, Eddie and Greta's pas de deux from "Swan Lake" is interrupted by an ugly duckling from down south--Myrtle.
A large rift in Cory and Shawn's friendship comes along when Cory videotapes a group of teen miscreants red-handed, but it turns out that they are Shawn's relatives.
Louis and Briggs are called in to investigate a murder that has taken place during the re-creation of a medieval battle scene. However they are more concerned with the police football quiz.
Louis and Briggs are cuffed to a notoriously slippery customer as they escort him to his latest prison by train. So how do they end up crossing the Yorkshire moors carrying a toilet door?
When three youths are charged with shooting a couple, one of them insists that, while they robbed the couple, someone else fired the gun.
Cyberbiotics are cutting down the rainforest in Guatemala, and have hired Jackal and Hyena to take care of the local Gargoyle clan.
Tisha Campbell hosts a special retrospective look back at the best of the last 99 episodes. Episode includes many of the special moments from the show, outtakes, and Tisha's own insight into the laughter behind the show, that made it such a success.
The ER hosts roughly a dozen pregnant women when a sprinkler bursts in the maternity ward. Carter plays tour guide for the visiting surgical intern hopefuls before going through the interview himself. Benton tries to bring a hopeless patient back from the brink of death in a marathon surgery. Jerry tries to convince the others that basketball player Scottie Pippen visisted. Doug visits his father.