Following Giordino as he makes use of the mysterious information from his burn box, XIII and Jones find themselves looking for a young boy whose parents Giordino has brutally murdered.
XIII is hot on the trail of now-exposed CIA director Giordino and tracks him to a safe deposit box in Moscow where Giordino has secreted money, documents and blackmail materials in case of an emergency.
Robin and Barney bond when they intervene in Ted's relationship, and Marshall and Lily watch a ticking clock as he fears that he soon will be the victim of food poisoning.
When House discovers that the experimental drug he's been using causes fatal tumors, he decides to attempt to excise them himself. However, he can't complete the surgery and ends up needing Cuddy's help. Meanwhile, Thirteen's friend from prison (Amy Landecker), a relapsed drug user, arrives at her apartment needing medical care after being stabbed. With her friend unwilling to go to the hospital, Thirteen enlists Chase's assistance when the friend loses sensation and movement in her arm. Also, Taub receives some unexpected news that could change his life.
Before he can kiss the bride, Chuck must enlist his wedding party to take down Vivian Volkoff and stop her from destroying the big day. When he turns to Alexei Volkoff for help, the CIA sends its toughest agent, Clyde Decker, to stop them.
The episode continues from the early events of the Constance Alumni event. Georgina Sparks turns up at the event looking for trouble. Serena and Vanessa reluctantly join forces to find Dan and Charlie, who does not take Dan's rejection of her well. Blair must make a choice between the men in her life when her life is in danger by Russell.
Global eats are sampled in Brighton, Colo., San Antonio and Tampa. Included: homemade German kraut; Moroccan couscous; Baja fish tacos.
When Five-0 gets too close to the truth about Wo Fat and his associates, the criminal mastermind retaliates by trying to destroy the team. They've always played by their own rules, but when the Governor can no longer protect them, it's time for Five-0 to pay the consequences of their actions.
Nina and Fraser continue to get to know each other. Cherie returns to her job as a nurse at the hospital. Billie and Mick discover they will have to go through IVF in order to have a baby. Nina goes on a date with her fathers doctor Ben. Billie reveals to Mick she had two abortions during her teens.
After spending five months in Baltimore, Nina returns home after receiving news of her father Darcy's heart attack. Billie and Mick are now living at Nina's apartment and trying for a baby. Jimmy also returns after being abroad with new girlfriend Tammy. Nina finds out that Chris has moved to Brisbane with Alice and Lucy. Darcy asks Geraldine to renew their vows and Nina meets a new obstetrician, Fraser King, at the hospital.
The Wisteria Lane residents each enjoy a progressive dinner; Renee begins a short-lived relationship with a bartender; Bree sees a connection with Chuck; the housewives cover up a fatal accident.
A progressive dinner party thrown for Susan to celebrate her move back onto the lane leads to a shocking murder. Meanwhile, Gaby is stunned to learn the identity of the mysterious man who has been stalking her; Lynette and Tom attempt to put the spark back into their marriage by spending a few days alone together at a romantic Bed & Breakfast; after being placed under arrest for allegedly poisoning Paul, Susan must convince the police that she was being framed for the deed by Felicia; Bree begins to suspect that her new boyfriend may be gay.
After the town's annual Lobsterfest is cancelled by a storm, Bob defiantly opens his doors for a festive celebration. When he wakes the next morning, Bob finds the restaurant in disarray and that the town has spurned him, but Bob won't let that deter him from further involvement in the celebratory weekend.
After finding the keys to every door in Springfield, Lisa finds a hidden room beneath the elementary school.
The invaders capture a fleeing and pregnant Lucrezia as they march on Rome, but she charms King Charles and is allowed to persuade her brother Juan to withdraw his hopelessly outmatched defensive troops; Pope Alexander VI awaits to learn of his fate as Charles enters the city and makes his way to the Vatican.
Jailbot is starting to show his age. And when Jared buys a sleek new replacement online, it might be time to put the Warden's beloved old companion down into storage.
Bonnie and Lois take a little trip to Paris where Bonnie crosses the line.
Francine gets a job at Stan’s office, which cramps Stan’s style and his ability to flirt with co-workers. When Francine retaliates with a little flirting of her own, war breaks out at work.
Tomoe is pressured by her mother to attend a marriage interview in a week. Meanwhile, the Kissuiso pays host to a group of rowdy 'survival gamers' who take their roleplay very seriously and cause various troubles for the employees. Planning to quit her job and return home, Tomoe decides to try and drive the gamers out and get fired. However, her attempts to irritate the gamers have the opposite effect, responding well to the gamers and making her appreciated by the other employees. As a result, Tomoe decides not to return home as she enjoys working at the Kissuiso.