When Chuckie discovers that Kimi is upset, he comes to the conclusion that she hates how her room looks. The gang decides to help him redesign it for her while Angelica keeps Kimi busy. Dil tries giving advice, but they choose to ignore him. It is later discovered that she is homesick for Japan and her biological father. Chas and Kira have a big surprise for Kimi.
Pig's brothers won't let him go on an adventure on his own knowing that he's too young. The Super Readers travel to the Tom Thumb book. They have discussions about the book.
Grylls travels to Panama, where he travels in the equatorial heat through mangrove swamps and rain forest, and endures more than 100 mosquito bites and one painful snake bite.
Nick and Eddie go to New York to try bringing Owen back to Knights Ridge and his family. Hannah has to deal with her true feelings for Nick.
An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.
The disappearance of an ultimate fighter leads the team to investigate his background, where they learn the man had a number of enemies.
George tries to find a hat that is as much fun as the Yellow Hat, and ends up creating a hat with blow up animals, frisbees, pictures of dachshunds, a rotating fish, bubble blower, and a raisin dispenser. But the Man accidentally wears it to a convention and George has to deliver the yellow hat! When Bill tells George it was a possum that ate the bird food from the bird feeder, George stays up to see what a possum looks like. But then he notices that it has lost its family, so he looks and finds it. Along the way he meets more nocturnal animals and makes almost everyone in the country think he is "The Lake Creature of Lake Wannasink Lake".
The gang gets locked out of the house by a new security system, so Peas must discover how to open the door.
A crisis caused by Wilhelmina has the team at Mode struggling to meet a deadline under extreme time constraints. Consequently, Alexis is forced to flirt with the printer for an extension, and Betty and Daniel try to free a teen star out of rehabilitation for a re-shoot.
Hodges puts the lab techs through a series of "murder games"--a set of bizarre, hypothetical murder scenarios which all take place in the lab.
Buizel is more interested in Ash's gym training, and Aipom is more interested in Dawn's contest training. Thus, Zoey suggests that Ash and Dawn do a trade.
When Vince bites a rare jazz record, the Jazz Beast enters his bloodstream.
Thanksgiving has arrived and Nick George wants to spend the day with his wife and daughter, but Tripp has another idea. Tripp wants Nick to set up a meeting with Simon Elder so Tripp and Simon can talk face-to-face once and for all. Meanwhile, Letitia helps Karen try and to get closer to Nick. Brian fights to keep his ex-girlfriend, Andrea, from taking his son away from him while Jeremy goes on a first date with Sofia.
Cooper returns to the online dating game with surprising results, Addison goes on a date with one of Violet's patients, and Naomi and Sam make a house call at a convent.
George is tired of the same old tub toys. When he tries some new toys in the tub and drains it afterwards, all of the toys get washed down the drain! After trying to fill the tub with water again it backs up. The Man decides to call his plumber who always fascinates George with his work. The plumber fixes the clog and leaves, and the Man also leaves, to buy George some new bath toys. Afterwards, George is faced with another clog, this time in the dishwasher and decides to fix it himself, dismantling not only the plumbing in the apartment but also in the basement. After turning the plumbing back on, George winds up flooding portions of the apartment building.
The designers are asked to create a two-piece garment for Sarah Jessica Parker's "Bitten" line. After pitching their designs, Parker chooses seven who will be team leaders, working in teams of two to create the design. They have $15 and one day to complete their look.
Tired of being considered a "goody goody" by the popular kids, Susie tries desperately to prove that she can be a bad girl.
Ned, Emerson, and Chuck's next case involves an olfactory assistant who was killed when her scratch-'n'-sniff book combusted.