After a federal witness is killed, the US attorney arrives at the Lightman Group to take the next witness in line, Reynolds, into protected custody. Cal feels that the US Marshals Service cannot protect Reynolds, so he takes him "hostage" and demands that he be able to run the investigation into the witness's death. During his investigation, he finds out that while undercover Reynolds did drugs and killed a man and wants to keep it a secret to avoid prosecution after he finds out that his handler (Alicia Coppola) did not properly report the event. Through his own undercover operation, Cal records the handler admitting that she led Reynolds to believe that everything was all set legally, and the US attorney subsequently takes her into custody. Meanwhile Loker and Torres discover that the original witness was killed after the cell phone that his mistress provided was tracked to his safe house's location.
Claire is determined to get to the bottom of the Sorority Rush attacks on her own, until H.R.G. intervenes only to realize he may be the source of her troubles. Meanwhile, Peter's new ability is a perfect fit for his job and gives him the opportunity to help Emma accept her new life. Elsewhere, Sylar's battle at gaining full control over Matt's body escalates with potentially dangerous implications at stake.
Alan and Charlie are shocked when they wake up next to a strange woman, and try to find out what happened.
Haley returns to the stage and Brooke receives life-changing news. Meanwhile, Dan Scott returns to Tree Hill much to the chagrin of Nathan, who is about to sign a new NBA contract with the help of his agent Clay.
Following workers at the Pennsylvania SPCA, which rescues more than 10,000 animals each year, including domestic pets, and exotic and dangerous creatures.
After a wild night out, a teenage girl is brought to Princeton Plainsborough with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, Wilson and House spend a weekend away from the hospital to attend a medical conference, but things don’t go as planned when House’s private investigator, Lucas returns.
Jenny wants to be the Queen Bee of not only Constance but of all the Upper East Side, as she lands the hottest escort for the Cotillion. Meanwhile Dan and Vanessa try to convince Olivia to stay in NY by showing her the "true college experience". Leighton Meester's new single "Somebody to Love" is featured in the episode, along with performance from Plastiscines.
Eight Canadians with poor driving skills are sent to an army base. They undergo challenges to enhance their driving abilities. Weekly, the most improved driver leaves. The last remaining participant is deemed Canada's Worst Driver.
Michael and Jeffery's kitchen is cramped, and their basement is dark and outdated. While Hilary works to fix their home, David struggles to find them a new home that meets their needs and fits within their unrealistic budget.
Horatio Caine calls Las Vegas CSI Ray Langston to come to Miami when a severed leg found in the Everglades is discovered to belong to a girl who went missing in Las Vegas a week earlier. The crossover continues on CSI:NY S06E07 Hammer Down (II) and CSI: Crime Scene Investigation S10E07 The Lost Girls (III).
Erza asks Gray and Natsu to form a team with her to stop a corrupt guild from using a dark magic that has the power to sap the lives of everyone in Fiore!
Lizzie finds herself in trouble after an incident at school, and Cassie's art may take her back to New York City for college.
Charles' career plans worry Cassie when he talks about joining the military, and Lizzie's budding thespian career may be cut short when the school musical is canceled.
Kitty is devastated when she must face the aftereffects of her cancer treatment. Meanwhile, Nora makes an unexpected friend; and Scotty's father shares some shocking news about his marriage.
Declan sets his sights on Holly J, but will her bad attitude cause him to stop chasing her?
Holly J falls hard for Declan and finally realizes the fuss about this "love" thing.
Believing Ofdensen is dead, Dethklok is forced to become their own managers while dealing with repairs to the destroyed Mordhaus and trying to plan their biggest concert to date. Their efforts are stalled however when a past acquaintance cuts off their unlimited financial freedom to get revenge against the band.
After Cleveland has "the talk" with Roberta, Cleveland Jr. becomes scared and takes a vow of chastity. Meanwhile, Rallo becomes a church greeter.
Dexter finds himself enjoying a brief moment of tranquility. He's finally managed to strike a balance between work, family... and other pursuits. But he's keenly aware that times like these aren't meant to last. When Miami Metro discovers a string of murders connected to a prominent photographer, Dexter sees an opportunity for a clean kill. However, his plans seem to be thwarted every step of the way. Quinn has taken a renewed interest in Dexter's nightlife. Dexter's plans to keep Astor and Cody distracted with new activities soon backfire. Even Harry disapproves of Dexter's choice of pastime, urging him instead to focus his efforts on the Trinity Killer. Meanwhile, Debra returns to work, frustrated to find everyone treating her with kid gloves. She decides to concentrate on her pursuit of the Trinity Killer as well as delving into her father's checkered past - investigations which Dexter fears might lead her to danger - or worse, the truth.