Melinda helps a group of college girls after one of their friends dies and begins to haunt them. Melinda must get Rachel to believe she is not Bloody Mary.
While CSI tackles cases involving a teen beheaded in a go-cart accident and the murder of an iconic gentleman's magazine publisher, Ecklie confronts Gil and Sara about their concealed affair.
Moretti begins to make his presence felt, as he implements changes in the way patients are seen. The ER staff differ on how procedure when a patient comes in with a bullet in him needed as evidence. Neela finds herself the object of more attention that she wants, or needs. Abby had passport woes, and struggles with the changes being made. Pratt and Morris find themselves forced to defend their actions, Hope prepares for a new mission, and Gates finds himself labeled the reject in his new assignment.
The gang agrees to sell Paddys when they get an offer that is too good to refuse, but it forces the bar's non-partners, Dee and Charlie to find new jobs.
Mac teams up with Frank and Charlie to create a public access newscast after he misses his chance at fame in the news. Meanwhile, Dennis and Dee try to make it big in the club scene.
As the cast and crew of TGS with Tracy Jordan returns for a new season, Liz is excited to see Jack again. However, her excitement quickly fades as Jack insists that Liz is still not over Floyd. Meanwhile, Jerry Seinfeld shows up at Jack's office in an upset mood after Jack announces his newest plan. Finally, Kenneth becomes Tracy's office wife when Tracy separates from his wife and Jenna returns to set a whole lot heavier now that she has been involved in Mystic Pizza: The Musical!.
Through a suggestion from Zoey in order to help her recover from her early exist at the Hearthome contest, Dawn participate in the Hearthome City Tag Battle Competition with Ash and Brock. During opening day of the Hearthome City Tag Battle Competition, Ash, Dawn and Brock learn who they will partner with. However, Ash discovers his teammate is his rival Paul.
Arriving in Hearthome City, Ash and Brock enter a tag battle, after the latter finds out that the Gym Leader isn't there to challenge Trainers to a battle. Meanwhile, Dawn competes against Nando, Zoey and Jessilina in the Hearthome City Pokémon Contest. However, Dawn finds herself in a discouraging situation.
The team considers if a father who cleans crime scenes for a living led to his disappearance with his daughter.
Belle is invited to the most prestigious adult party in the country, however her client doesn't want to join the action. So she tries to get rid of him just to engage with a couple she just met - however her personal life gets in conflict with that.
Betty gets a little overwhelmed about Wilhelmina's brand new hunky bodyguard. Plus, Henry returns to pay for insurance, which has Betty concerned about their relationship. Because of the fatal crash, Alexis gets amnesia and Bradford uses it to his advantage. Hilda comes to terms with recent events. And Amanda gets a surprise inheritance from her late biological mother.
Ryan returns to Scranton with a plan to bring Dunder Mifflin into the digital age by launching a new website - Dunder Mifflin Infinity. Michael is worried about ageism and attempts to win back clients using old fashion business skills. Relationships are on the forefront as Ryan returns to an eager Kelly, Jim and Pam are outed to the office, and Angela is still upset with Dwight about her cat.
Clark and Lois meet Smallville's newest arrival face-to-face, and she has some surprising news. Clark decides to leave Smallville and continue with his superhero training but Jor-el informs him that a new Kryptonian menace has arisen.
Peggy is given a difficult assignment. Roger's work problems provide new opportunities for Don, and Pete grows more frustrated. Betty finds a new outlet for her growing dissatisfaction.
A patient is in the hospital because they fell asleep in a hazardous situation. A patient's home laboratory blew up in an apartment building and the victims flood the hospital. Alex investigates the cause of the incident by talking to a really old guy who lived in the building. Jane Burke shows up to deal with what her son left behind. Lexie tries to talk to Meredith. Callie is overwhelmed by her new position while Bailey is searching for things to do.
Colonel Sheppard and his team embark on a risky mission to steal a Z.P.M. power module from the Replicators -- but must rely on a compromised Dr. Weir to succeed.
Seven demons, based on the Seven Deadly Sins, are released into the world and the brothers must combat them with the aid of a married Hunter couple.