Vince's new agent wants him to do a period film. In the meantime Eric and Vince agree to have lunch with Ari and Turtle plans Vince's birthday party.
After being divided into three teams of two, the final six candidates travel to Las Vegas to launch a promotional campaign for a Trump project.
The boys try to profit from their latest scam of selling the meat that they have stolen from the grocery store. Meanwhile, Lucy is pregnant and Julian accepts a new job that is beneath him.
Tim and Eric are late in delivering the episode and rely on Hamburger Taxi to get there on time.
When a mother falls seriously ill, staff at the hospital are faced with a dilemma.
When small things happen, some Camdens see them as signs. Lucy and Eric both cross paths with a black bird. They both come to the conclusion that this is a sign, and a bad one at that. Meanwhile, Ruthie gets a sign on her own. When she loses a diamond in the ring that T-Bone gave her as a promise to get engaged someday, she thinks that this is her sign that maybe being with T-Bone is not the best choice.
Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.
Henry contemplates an alliance with Holy Roman Emperor Charles V of Spain despite his "Field of Cloth of Gold" ceremony celebrating allegiance to France, and executes a rival; Elizabeth gives birth to the king's illegitimate son.
Bobby and Janice host a wild 47th birthday bash for Tony at their Adirondacks vacation home. Tony's actions following Johnny Sack's arrest come back to haunt him.
The US government wants to cut over $3 billion out of the science budget, and NORBAC has to prove they deserve to stay in operation. Meanwhile, a West Nile like virus is breaking out in San Francisco, but it's showing some abnormal traits. A scientist at the University of Toronto claims to be able to help Owen with his addiction.
Morgan and Ancient Mai must come to Harry for protection and shelter from powerful enemies of Mai's. They make it to the relative safety of Dresden's place, but suddenly find that they are all trapped by a powerful spell. Now Harry must work with them to find a way out before the spell turns deadly.
A man hires Vicki to figure out if his wife is cheating on him. After she is found dead, the man is the prime suspect.
Martha takes her first trip in the Tardis, all the way back to Elizabethan England. She and the Doctor hear of a series of bizarre deaths and discover that playwright William Shakespeare is being controlled by dangerous witch-like creatures. It seems the time-travelling duo must defeat ancient forces to prevent history from being rewritten.
Ron comes home to unexpectedly find his new adopted baby sister named Hana Stoppable in his room. At the same time, he has to take care of a sack of flour for health class. Meanwhile, Kim and Ron team up with Yori to stop Monkey Fist yet again.
While driving on a Florida highway, a bus of escaped felons rams into the RV. Ben transforms into Stinkfly (though not intentionally) and tries to stop them. With a little help from Grandpa's handy driving, and a magic spell from Gwen, the felons are put back in jail. On the news, the Tennyson's hear about purple lightning delaying a space shuttle launch. Remembering the lightning from the encounter with the werewolf and mummy aliens, they head to Cape Canaveral. At the Space Center, Ben comes under attack by the werewolf and mummy aliens, and new Frankenstein alien. However, why is the purple lightning occurring, and what ties does it have to an old "friend"?
Jammerhead escapes from prison and confronts the Turtles during a visit from Starlee's alien family.
Kaz is summoned to a secret meeting by Chaor, lord of the Underworld, and is ordered to do battle with a Chaotic player who has a Lord Van Bloot card when the real Lord Van Bloot plans to stage a revolution against Chaor.
Megan's been extremely secretive and Drake and Josh investigate to find out what she's up to. The clues lead to a new boyfriend and all seems wonderful until they find out Megan's new beau may be trouble.
The trio need to raise money for a music festival; Ned borrows money from Missy that he must work off to pay her back; Moze gets her money from hard work; Cookie tries to get money from entertainment. Ned goes to Seth's party with Missy and tries to ditch her when Suzie unexpectedly shows up; Moze tries to kiss Ned to determine if she'll see sparks; Cookie is not invited, so he sneaks in as the girl named Simone.