Hal's friend Trey tells him to come to his dental office when he looses a tooth during a poker game, but their friendship becomes in jeopardy when Hal's faced with a $2,000 bill and causes a fight between them. Reese, meanwhile, teaches Lois how to ride a bike, while Malcolm and Dewey find sleeping as their new favorite pastime.
In order to help a mother and her unborn child, David starts a research to fight a very strong strain of the HIV virus which she has and for which there is no known cure.
While the gang begins to turn on itself, Tony finds himself at the threshold.
Although often overlooked, caves are remarkable habitats with bizarre wildlife. Explore the structures created inside the earth as well as the adaptations animals have made to thrive in these environments.
Bill gets a new home security system, Nicki throws a birthday party, new neighbours move in, and Margene meets her mother-in-law. Meanwhile, there's a break-in in Bill's hardware store.
Peter gets a vasectomy and loses all his sex drive. Lois begins to gain weight, and as a result, Peter's regains his interest in his wife. When Lois' habits get out of control, she has a heart attack. The surgeon must remove Lois' fat to reach her heart, returning her to her normal weight. Meanwhile, Stewie's half-brother Bertram returns to confront him, where they have a war for control over the playground.
Hercule Poirot's solicitor, Gilbert Entwhistle, asks Poirot to help solve a riddle and a murder.
A father is murdered and his daughter becomes a target of an assassin, stirring some hard memories for Jordan. Elsewhere, a high profile family makes life hard for Dr. Macy when their son is killed in a tragic accident.
Hank gets sucked into Kahn's get-rich-quick scheme when Kahn buys the car wash that hosts car cruising on Friday nights. But Kahn wrecks the business by trying to cut corners, and gets bought out by Buck Strickland. Meanwhile, Peggy tries to figure out if Nancy is deliberately refusing to take her calls.
The body of a man is found in an allotment, having been struck on the head and drowned in the night, but no one comes forward to identify him.
The Santos campaign meets up with Rock the Vote and lots of musicians are around for a star-studded episode. Helen gives a lecture to MANA (a National Latina Organization, formerly Mexican American National Association) but her heritage doesn't help her when trying to deliver part of the Santos campaign message. Toby is being pressured by the Attorney General, Blake, to reveal his source and it's affecting his relationship with his kids. He tries a little psychological warfare of his own to get Blake to back down. Toby is also giving Josh campaign advice which includes plans to increase courtship of the Latino vote. Elsewhere on the campaign trail, it's Halloween and Toby's kids and Santos' kids are dressing up for the occasion.
Wedding plans occupy the girls, and Shane is reunited with her family. Helena pitches in to have Carmen's family flown to Canada, Jenny and Max drift apart, and Kit has stunning news. Peggy Peabody reconnects with her daughter -- but does it last? Finally, Tina has second thoughts about Angelica's custody arrangements, leading Bette to take desperate measures to be with her daughter.
Goren and Eames investigate the death of Eric Newsome, an urban explorer who was found in a water tower. During their investigation, they learn that Eric had been looking into the files of Dr. Everett Janns, an OB/GYN who had examined his sister Nikki's boyfriend Drew's mother years earlier when she had been carrying his sister Lisa. Lisa Ramsey was born with spina bifida, and Victoria Carson was suing her primary OB/GYN, Dr. Dominic McKenna, with a wrongful life suit, charging that he did not perform the necessary tests needed to establish whether or not her child had spina bifida, which would have influenced whether or not she had an abortion.
When a poison-soaked towel turns up at the station, Lilly re-opens the 1973 case of a murdered female college tennis star.
April Fools Day: Ned, Cookie, and Gordy team up to fool the king of April Fooling: Vice Principal Crubbs. Moze tries to break up with Seth, but he thinks it's a prank. Excuses: When a dog actually eats Ned's homework, nobody believes his excuse.
Vilgax tries to get the Omnitrix for himself while Grandpa Max's strange past becomes known, causing a showdown between Vilgax and the Tennyson family.
With the outbreak-mutant situation the Turtles feel they have to deal with and Donatello sick his brothers leave him with Casey and April for care. But Donatello is not sick but in the last stages of a second mutation.
Vlad is back, only now he's afflicted with a serious case of ecto-acne, a direct result of the college lab accident with Jack and Maddie. To ensure Danny helps him find a cure, Vlad infects Sam and Tucker with his disease, and Danny turns to Clockwork for help. Danny convinces Clockwork to let him go back in time to make sure the accident that injures Vlad never happens. Unfortunately, when he changes the past, he changes the present. When he arrives back in the present day, Maddie is married to Vlad and living in Wisconsin, and Jack's a ghost named Jack Plasmius! Now, Danny must go back in time for a second time to ensure his parents get together, but when he does, will that mean ecto-acne doom for Tucker and Sam?